Research on indirect intercell-recognition in the central nervous system

• Project/Area Number: 23650174
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: SATO Kohji 浜松医科大学, 医学部, 教授 (80235340)
• Co-Investigator(Kenkyū-buntansha): MIKAWA Sumiko 浜松医科大学, 医学部, 助教 (70359743)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 神経回路網 / 神経科学 / 骨形成因子 / 知覚神経系 / 神経回路形成

Research Abstract

We studied whether BMP signaling pathways are involved in indirect intercell-recognition in the central nervous system. And we found that BMPs, their receptors and their antagonists were abundantly expressed in cell bodies, dendrites, axons and extracellular space. This means that BMP signaling pathways are involved in indirect intercell-recognition between projecting neurons and their receiving neurons. In future, we want to reveal which kinds of information are transmitted by this system.

Research Products

• [Journal Article] Disruption of spine homeostasis causes depression (2013)
  • Author(s): Sato K
  • Journal Title: Med Hypotheses Volume: 81 Issue: 1 Pages: 5-9
  • DOI: 10.1016/j.mehy.2013.03.025
  • Peer Reviewed
• [Journal Article] *equal contribution Adventitiavasa vasorum arteriosclerosisin abdominal aortic aneurysm (2013)
  • Author(s): Tanaka, H*., Zaima, N*., Sasaki, T., Hayasaka, T., Goto-Inoue, N., Onoue, K., Ikegami, K., Morita, Y., Yamamoto, N., Mano, Y., Sano, M., Saito, T., Sato, K., Konno, H., Setou, M
  • Journal Title: Plos One Volume: 8 Issue: 2 Pages: e57398-e57398
  • DOI: 10.1371/journal.pone.0057398
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase-2 deficiency impairs aortic atherosclerotic calcification in ApoE-deficient mice. (2013)
  • Author(s): Sasaki T, Nakamura K, Sasada K, Okada S, Cheng XW, Suzuki T, Murohara T, Sato K, Kuzuya M.
  • Journal Title: Atherosclerosis. Volume: 227(1) Issue: 1 Pages: 43-50
  • DOI: 10.1016/j.atherosclerosis.2012.12.008
  • Peer Reviewed
• [Journal Article] Placenta-derived hypo-serotonin situations in the developing forebrain cause autism (2013)
  • Author(s): Sato K
  • Journal Title: Med Hypotheses Volume: 80 Issue: 4 Pages: 368-72
  • DOI: 10.1016/j.mehy.2013.01.002
  • Peer Reviewed
• [Journal Article] Pre- and post-synaptic switches of GABA actions associated with Cl - homeostatic changes are induced in the spinal nucleus of the trigeminal nerve in a rat model of trigeminal neuropathic pain. (2012)
  • Author(s): Wei, B., et al,
  • Journal Title: Neuroscience Volume: 228 Pages: 334-348
  • DOI: 10.1016/j.neuroscience.2012.10.043
  • Peer Reviewed
• [Journal Article] Spine homeostasis as a novel therapeutic target for schizophrenia. (2012)
  • Author(s): S. Yamagishi, S. Mikawa, H. Furukawa, T. Sasaki, T. Ito, T. Ueki, Kohji Sato.
  • Journal Title: Journal of Clinical Pharmacology & Biopharmaceutics. Volume: S1-001
  • Peer Reviewed
• [Journal Article] Disruption of spine homeostasis causes dopaminergic compensatory up-regulation, resulting in schizophrenia (2012)
  • Author(s): Sato K
  • Journal Title: Med Hypotheses Volume: 79 Issue: 3 Pages: 304-7
  • DOI: 10.1016/j.mehy.2012.05.015
  • Peer Reviewed
• [Journal Article] CLP36 and RIL recruit α -actinin-1 to stress fibers and differentially regulate stress fiber dynamics in F2408 fibroblasts (2012)
  • Author(s): Miyazaki K, Ohno K, Tamura N, Sasaki T, Sato K
  • Journal Title: Exp Cell Res Volume: 318 Issue: 14 Pages: 1716-25
  • DOI: 10.1016/j.yexcr.2012.05.006
  • Peer Reviewed
• [Journal Article] BMP2, BMP4, noggin, BMPRIA, BMPRIB, and BMPRII are differentially expressed in the adult rat spinal cord (2012)
  • Author(s): M. Miyagi, S. Mikawa, T. Sato, T. Hasegawa, S. Kobayashi, Y. Matsuyama, Kohji Sato
  • Journal Title: Neuroscience Volume: Vol.203 Pages: 12-26
  • DOI: 10.1016/j.neuroscience.2011.12.022
  • Peer Reviewed