| Project/Area Number |
23659103
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Teikyo University |
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Principal Investigator |
ABE Hiroyuki 帝京大学, 医療技術学部, 講師 (80309335)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | トランスポーター / GLUT1 / PiT1 / PiT2 / 小脳 / 発達 / nutrient transporter / 代謝 / 分化 / cerebellum |
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| Research Abstract |
Present research focuses on studying possible roles that nutrient transporters can play in the postnatal development of murine cerebellar cortex. First, we established a simple method to inject reagents into the cerebellum of newborn mouse in order to suppress the expression of nutrient transporters based on the activity of the injected reagent, and presented the achievements in the 61st. Annual Meeting of Japanese Association for Laboratory Animal Science (Sapporo, JAPAN) (manuscript in preparation). Next, we designed a reagent that specifically suppresses the expression of a nutrient transporter based on the nucleotide sequence of its gene, and confirmed its effects on a murine cultured cell line. This reagent will be injected in the cerebellum of newborn mouse, and its possible effects on the postnatal development of cerebellar cortex will be studied.
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