Study of bacterial adhering mechanism onto mammalian epithelial cells
Project/Area Number |
23659225
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Bacteriology (including Mycology)
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Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
IKE Fumio 独立行政法人理化学研究所, 独立行政法人理化学研究所, 専任研究員 (40183157)
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Co-Investigator(Kenkyū-buntansha) |
KOKUBO Toshiaki 独立行政法人放射線医学総合研究所, 研究基盤センター, 課長 (10425663)
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Research Collaborator |
松下 悟 独立行政法人放射線医学総合研究所, 研究基盤センター
HATTORI Masahira 東京大学大学院新領域創成科学研究科, 大学院・新領域創成科学研究科・附属オーミクス情報センター, 教授
OSHIMA Kenshiro 東京大学, 大学院新領域創成科学研究科・附属オーミクス情報センター, 特任助教
MURATA Takehide 独立行政法人理化学研究所, 遺伝子材料開発室, 遺伝子材料開発室
OKUBO Masato 独立行政法人理化学研究所, 遺伝子材料開発室, テクニカルスタッフ
KAJITA Ayako 独立行政法人理化学研究所, 実験動物開発室, 人材派遣
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | CARバチルス / 肺炎病原菌 / 間質性肺炎 / マウス / ゲノムシークエンシング / 培養 / 感染 / 細胞付着機構 |
Research Abstract |
The cilia-associated respiratory bacillus (CARB), a gram-negative extracellular bacterium, causes chronic respiratory disease in rodents. In this research, we got full genome sequence of CARB (about 1.44 Mbp long with around 1,200 coding sequences). Using this information, we also designed custom DNA array chip to analyze CARB's RNA expression when CARB attached to and grown on epithelial cells in vitro.
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Report
(3 results)
Research Products
(39 results)
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[Presentation] Draft sequencing of rodent pneumonic CAR bacillus2012
Author(s)
Ike F, Kajita A, Yoshiki A, Okubo M, Murata T, Oshima K, Hattori M, Kokubo T
Organizer
The 11th Awaji Interna-tional Forum on Infection and Immunity
Place of Presentation
Awaji Yumebutai International Con-ference Center, Awaji, Hyogo, Japan
Related Report
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[Presentation] Draft sequencing of rodent pneumonic CAR bacillus2012
Author(s)
Ike F, Kajita A, Yoshiki A, Okubo M, Murata T, Oshima K, Hattori M, Kokubo T
Organizer
The 11th Awaji International Forum on Infection and Immunity
Place of Presentation
Awaji Yumebutai International Conference Center, Awaji, Hyogo, Japan
Related Report
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