Molecular mechanism of memory impairment in Alzheimer's disease mice model
| Project/Area Number |
23700429
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Saitama Medical University (2012-2013)
The Institute of Physical and Chemical Research (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | アルツハイマー病 / タウ / 長期抑制 / 新規モデル / シナプス / グルタミン酸受容体 / 生化学 / 神経病理学 / モデルマウス / ストレス / アミロイドベータタンパク質 |
|---|
| Research Abstract |
In this study, I focused on tau protein, which is related to tauopathy including Alzheimer's disease. Especially, tau phosphorylation is thought to relate to onset of neurodegenerative disease, I established a new mice model with accelerated phosphorylation of tau. Moreover, recent studies suggest the presence of tau in synaptic region. I focused on a receptor-related synaptic protein and suggested a new mechanism on the regulation of receptor trafficking.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Localization of mature neprilysin in lipid rafts.2012
Author(s)
Sato K, Tanabe C, Yonemura Y, Watahiki H, Zhao Y, Yagishita S, Ebina M, Suo S, Futai E, Murata M, Ishiura S.
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Journal Title
J. Neurosci. Res.
Volume: 90
Issue: 4
Pages: 870-877
DOI
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Peer Reviewed
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[Presentation] in vitroおよびin vivoにおける低分子化合物によるtau凝集抑制作用の検討2011
Author(s)
添田義行,吉池裕二,前田純宏,木村哲也,村山美由紀,溝呂木達也,山下俊治,柳下聡介,斎藤臣雄,長田裕之,高島明彦
Organizer
日本認知症学会
Place of Presentation
東京
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