Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Research Abstract |
The incidence of skin squamous cell carcinoma (SCC) induced by activation of oncogenic Ras is affected by polymorphism of patched (ptch) gene in mice (C57BL/6 strain: resistance, FVB strain: high susceptibility). In this study, we obtained K5-Hras transgenic mice of C57BL/6 background which carry ptch allele of FVB strain (K5-Hras Tg; ptchFVB/FVB). Our results suggest that the SCC formation is promoted K5-Hras Tg; ptchFVB/FVB mice as compared with the K5-Hras Tg; ptchB6/FVB mice. However, the tumor latency in the model system of these mice was not affected by loss of Bach1
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