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Development and clinical application of the pigment material responded by radiation for safe radiotherapy

Research Project

Project/Area Number 23791390
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionUniversity of Tsukuba

Principal Investigator

OSHIRO Yoshiko  筑波大学, 医学医療系, 研究員 (50550159)

Research Collaborator MORITAKE Takashi  筑波大学, 医学医療系, 講師 (50450432)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords放射線治療 / 放射線感応性色素素材 / ゲル線量計 / 線量計 / 医療安全 / Proof of concept
Research Abstract

We developed polymer gel dosimeter made from natural polymer as base matrix and methacrylate monomer that can show irradiation field and dose just after the radiotherapy. Using this, we have made proof of the concept that we can conduct radiotherapy more safely if we can confirm irradiation field and irradiated doses just after the radiotherapy. We has already applied to patent the concept and developed polymer gel. Also, we are planning to file international patent, and to put into production.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (20 results)

All 2013 2012 2011

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Delayed radiotherapy for patients with localized prostate cancer: validation by propensity score matching2013

    • Author(s)
      Nakayama H, Kanemoto A, Kikuchi K, Matsuki K, Tomobe M, Tsukamoto S, Takeshima H, Oshiro Y, Sugahara S, Tokuuye K
    • Journal Title

      Anticancer Res

      Volume: 33(4) Pages: 1629-33

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The use of proton-beam therapy in the treatment of non-small-cell lung cancer2013

    • Author(s)
      Oshiro Y, Sakurai H
    • Journal Title

      Expert Rev Med Devices

      Volume: 10(2) Issue: 2 Pages: 239-45

    • DOI

      10.1586/erd.12.81

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proton beam therapy for unresectable hepatoblastoma in children: survival in one case2013

    • Author(s)
      Oshiro Y, Okumura T, Mizumoto M, Fukushima T, Ishikawa H, Hashimoto T, Tsuboi K, Kaneko M, Sakurai H
    • Journal Title

      Acta Oncol

      Volume: 52(3) Issue: 3 Pages: 600-3

    • DOI

      10.3109/0284186x.2012.760849

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dose-volume histogram analysis for risk factors of radiation-induced rib fracture after hypofractionated proton beam therapy for hepatocellular carcinoma2013

    • Author(s)
      Kanemoto A, Mizumoto M, Okumura T, Takahashi H, Hashimoto T, Oshiro Y, Fukumitsu N, Moritake T, Tsuboi K, Sakae T, Sakurai H
    • Journal Title

      Acta Oncol

      Volume: 52(3) Issue: 3 Pages: 538-44

    • DOI

      10.3109/0284186x.2012.718094

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proton beam therapy for inoperable recurrence of bronchial high-grade mucoepidermoid carcinoma2012

    • Author(s)
      Kanemoto A, Oshiro Y, Sugahara S, Kamagata S, Hirobe S, Toma M, Okumura T, Sakurai H
    • Journal Title

      Jpn J Clin Oncol

      Volume: 42(6) Issue: 6 Pages: 552-5

    • DOI

      10.1093/jjco/hys047

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of liver function after proton beam therapy for hepatocellular carcinoma2012

    • Author(s)
      Mizumoto M, Okumura T, 他15名
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 82 Issue: 3 Pages: e529-e535

    • DOI

      10.1016/j.ijrobp.2011.05.056

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Verification of beam delivery using fibrosis after proton beam irradiation to the lung tumor.2012

    • Author(s)
      Fukumitsu N, Oshiro Y, 他7名
    • Journal Title

      Lung Cancer

      Volume: (in press) Issue: 1 Pages: 83-8

    • DOI

      10.1016/j.lungcan.2012.01.007

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Results of Proton Beam Therapy without Concurrent Chemotherapy for Patients with Unresectable Stage III Non-small Cell Lung Cancer2012

    • Author(s)
      Oshiro Y, Mizumoto M, 他10名
    • Journal Title

      J Thorac Oncol

      Volume: 7 Issue: 2 Pages: 370-375

    • DOI

      10.1097/jto.0b013e31823c485f

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Outcome of T4 (International Union Against Cancer Staging System, 7th edition) or Recurrent Nasal Cavity and Paranasal Sinus Carcinoma Treated with Proton Beam2012

    • Author(s)
      Fukumitsu N, Okumura T, 他12名
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: (in press) Issue: 2 Pages: 704-11

    • DOI

      10.1016/j.ijrobp.2011.07.032

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Displacement of hepatic tumor at time to exposure in end-expiratory-triggered-pulse proton therapy2011

    • Author(s)
      Oshiro Y, Okumura T, Ishida M, et al.
    • Journal Title

      Radiother Oncol

      Volume: 99 Issue: 2 Pages: 124-130

    • DOI

      10.1016/j.radonc.2011.05.009

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hyperfractionated Concomitant Boost Proton Beam Therapy for Esophageal Carcinoma.2011

    • Author(s)
      Mizumoto M, Sugahara S, 他8名
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 81 Issue: 4 Pages: e601-e606

    • DOI

      10.1016/j.ijrobp.2011.02.041

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pediatric nasopharyngeal carcinoma treated with proton beam therapy. Two case reports2011

    • Author(s)
      Oshiro Y, Sugahara S, Fukushima T, et al.
    • Journal Title

      Acta Oncol

      Volume: 50 Issue: 3 Pages: 470-473

    • DOI

      10.3109/0284186x.2010.509106

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proton Beam Therapy for Hepatocellular Carcinoma: A Comparison of Three Treatment Protocols.2011

    • Author(s)
      Mizumoto M, Okumura T, 他15名
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 81 Issue: 4 Pages: 1039-1045

    • DOI

      10.1016/j.ijrobp.2010.07.015

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of radiotherapy for local control of asymptomatic adrenal metastasis from lung cancer2011

    • Author(s)
      Oshiro Y, Takeda Y, Hirano S, Ito H, Aruga T.
    • Journal Title

      Am J Clin Oncol

      Volume: 34(3) Issue: 3 Pages: 249-53

    • DOI

      10.1097/coc.0b013e3181dbb727

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 切除不能肝芽腫に陽子線治療を施行し2012

    • Author(s)
      大城佳子、他9名
    • Organizer
      長期生存が得られた1例 粒子線治療研究会
    • Place of Presentation
      指宿
    • Year and Date
      2012-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] ESTRO 312012

    • Author(s)
      Oshiro Y, 他10 名
    • Organizer
      Preliminary clinical results of proton beam therapy for advanced neuroblastoma
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2012 Final Research Report
  • [Presentation] 小児神経芽細胞腫に対する陽子線治療の初期経験2011

    • Author(s)
      大城 佳子、他10名
    • Organizer
      第24回放射線腫瘍学会
    • Place of Presentation
      神戸ポートピアホテル
    • Related Report
      2012 Final Research Report
  • [Presentation] Results of proton beams radiotherapy without concurrent chemotherapy for patients with unresectable stage III non-small-cell Lung cancer2011

    • Author(s)
      Oshiro Y,他12 名
    • Organizer
      ASTRO's 53^<rd>annual Meeting
    • Place of Presentation
      Miami Beach Convention Center, Miami Beach, America
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] ポリマーゲル線量計2013

    • Inventor(s)
      水本佳子(旧姓:大城),盛武敬,廣木章博,田口光正,山下真一
    • Industrial Property Rights Holder
      筑波大学,原子力開発機構
    • Filing Date
      2013-03-25
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] ポリマーゲル線量計2013

    • Inventor(s)
      水本佳子(旧姓:大城),盛武敬,廣木章博,田口光正,山下真一
    • Industrial Property Rights Holder
      筑波大学,原子力開発機構
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-03-25
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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