The role of sonic hedgehog signaling in intestinal injury
| Project/Area Number |
23791536
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YOSHIKAWA Kozo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (80448331)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMADA Mitsuo 徳島大学, 大学院・ヘルスバイオサイ エンス研究部, 教授 (10216070)
KURITA Nobuhiro 徳島大学, 病院, 特任教授 (30335814)
IWATA Takashi 徳島大学, 大学院・ヘルスバイオサイエンス 研究部, 准教授 (00380022)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ソニックヘッジホッグシグナル / 腸管修復 / サイトカイン / 腸管傷害 / Sonic hedgehog / 傷害再生 / 腸管バリア / 細胞接着因子 |
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| Research Abstract |
In intestinal stress rat model, the component of the Sonic hedgehog pathway was up-regulated and tight junction (Occludin, Claudin, ZO-1) was down-regulated. In cancer stem cell (CSC), Sonic hedgehog pathway was correlated with CSC.
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Report
(3 results)
Research Products
(19 results)
