| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Research Abstract |
The cornea is the transparent window covering the front of the eye. It is a refracting surface, and also serves as a barrier of the eye. If the cornea is deeply injured or robust inflammation occurs, it leaves a scar, which leads to vision loss.
Recently, Interleukin17 (IL-17)-producing helper T cell subset Th17 has been discovered. It has reported that IL-17 is a major contributor of autoimmune inflammation such as rheumatoid arthritis. In this research, we focused on the corneal inflammation and the IL-17 receptor expression. We discovered that upon corneal alkali injury or corneal infection, the expression of IL-17 receptor in the cornea is up-regulated.
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