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Roles of a novel protein in alveolar bone remodeling process

Research Project

Project/Area Number 23792434
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontic/Pediatric dentistry
Research InstitutionKyushu University

Principal Investigator

MURAKAMI Ayako  九州大学, 歯学研究院, 特別研究員 (10432923)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsPRIP / 骨リモデリング / 破骨細胞 / 骨代謝 / 歯牙移動 / 骨芽細胞 / 矯正力
Research Abstract

In this study, we investigated the possible involvement of PRIP in alveolar bone remodeling during orthodontic tooth movement. In PRIP-KO mice, tooth movement appeared to be reduced compare to the WT mice. Histological analysis showed the difference in distributions of osteoblasts on the tension side and osteoclasts on the pressure side of alveolar bones, respectively. Population of differentiated osteoclasts was decreased in KO mice compared with WT mice. These results indicate that PRIP is implicated in the regulation of bone remodeling during mechanical tooth movement

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Involvement of PRIP, phospholipase Crelated, but catalytically inactive protein, in bone formation.2011

    • Author(s)
      Tsutsumi K, Matsuda M, Kotani M, Mizokami A, Murakami A, Takahashi I, Terada Y, Kanematsu T, Fukami K, Takenawa T, Jimi E, Hirata M.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: Volume286 Number35 Pages: 31032-31042

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tsutsumi K, Matsuda M, Kotani M, Mizokami A, Murakami A, Takahashi I, Terada Y, Kanematsu T, Fukami K, Takenawa T, Jimi E, Hirata M.2011

    • Author(s)
      Involvement of PRIP, phospholipase C-related, but catalytically inactive protein, in bone formation.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: Volume286 Number35 Pages: 31032-31042

    • Related Report
      2011 Research-status Report
  • [Presentation] PRIP-KO mice exhibit the decreased tooth movement by orthodontic force2012

    • Author(s)
      Miho Matsuda, Ayako Murakami, Masato Hirata
    • Organizer
      第35回 日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of a novel protein in alveolar bone remodeling during orthodontic tooth movement2012

    • Author(s)
      Ayako Murakami, Miho Matsuda
    • Organizer
      Congress 22nd IUBMB 37th FEBS
    • Place of Presentation
      Sevilla, Spain
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of a novel protein in alveolar bone remodeling during orthodontic tooth movement2012

    • Author(s)
      Ayako Murakami, Miho Matsuda
    • Organizer
      Congress 22nd IUBMB 37th FEBS
    • Place of Presentation
      Sevilla,Spain
    • Related Report
      2012 Annual Research Report
  • [Presentation] PRIP-KO mice exhibit the decreased tooth movemet by orthodontic force2012

    • Author(s)
      Miho Matsuda, Ayako Murakami, Masato Hirata
    • Organizer
      第35回 日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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