Cellular responsibility and bioresorbability of reinforced carbonate apatite
Project/Area Number |
23890156
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Dental engineering/Regenerative dentistry
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Research Institution | Kyushu University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 生体材料 / 炭酸アパタイト / 破骨細胞性吸収 / 骨置換 / 強化 / 気孔率 |
Research Abstract |
Despite the fact that autograft or bone taken from the same patient is still the golden standard for the reconstruction of bone defects, it also shares serious shortcomings. These include invasion to healthy site to gather the healthy bone, limitation of morphology and the amount of collectable bone. To overcome these drawbacks, artificial bone substitutes are used. Among these, carbonate apatite (CO_3Ap) is ideal since the biological apatite of bone is CO_3Ap and can be replaced to natural bone completely through the process of bone remodeling cycle. Although, the mechanical property of CO_3Ap is not sufficient enough, we have successfully improved its mechanical property by calcium salt introduction method. The biocompatibility and bioresorbability of reinforced CO_3Ap was investigated in this study. The result showed that reinforced CO_3Ap showed biocompatibility and bioresorbability even though its resorption is lesser than unreinforced CO_3Ap.
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Report
(3 results)
Research Products
(2 results)