Regulation of ectodomian shedding by ADAM17 and remnant signaling
| Project/Area Number |
24390074
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUDA Shinji 愛媛大学, プロテオサイエンスセンター, 助教 (70398238)
INOUE Hirofumi 愛媛大学, 大学院医学系研究科, 講師 (70321635)
MATSUSHITA Natsuki 愛媛大学, 医学部附属病院, 研究員 (40271556)
JHO Takashi 名古屋市立大学, 大学院医学系研究科, 教授 (30231369)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | ectodomian shedding / ADAM17 / proHB-EGF / proamphiregulin / proTNF-α / annexin / レムナントペプチドシグナル / Shedding / HB-EGF / amphiregulin / TNF-alpha / 細胞膜蛋白質 / Ectodomain Shedding / TNF-α |
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| Outline of Final Research Achievements |
ADAM17, a transmembrane-type metalloprotease, sheds various transmembrane proteins on cell surface, which regulates cell signaling. Both type I transmembrane protein proHB-EGF and proAREG, and type II transmembrane protein proTNF-α are equally shed. However, ADAM17 binding proteins annexin reversibly affected on their ADAM17-induced shedding. We propose that the catalytic domain of ADAM17 can swing by binding different member of annexin and access to the different types of membrane proteins.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice.2013
Author(s)
Takemura T, Yoshida Y, Kiso S, Kizu T, Furuta K, Ezaki H, Hamano M, Egawa M, Chatani N, Kamada Y, Imai Y, Higashiyama S, Iwamoto R, Mekada E, Takehara T.
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Journal Title
Biochem Biophys Res Commun.
Volume: 437
Issue: 2
Pages: 185-191
DOI
Related Report
Peer Reviewed
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[Journal Article] Annexin A2 regulates a disintegrin and metalloproteinase 17-mediated ectodomain shedding of pro-tumor necrosis factor-α in monocytes and colon epithelial cells.2013
Author(s)
Tsukamoto H, Tanida S, Ozeki K, Ebi M, Mizoshita T, Shimura T, Mori Y, Kataoka H, Kamiya T, Fukuda S, Higashiyama S, Joh T.
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Journal Title
Inflamm Bowel Dis.
Volume: 19
Issue: 7
Pages: 1365-1373
DOI
Related Report
Peer Reviewed
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