Structure and movement of gliding machinery for Mycoplasma gliding
| Project/Area Number |
24390107
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|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Osaka City University |
|---|
Principal Investigator |
Miyata Makoto 大阪市立大学, 大学院理学研究科, 教授 (50209912)
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|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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|---|
| Keywords | 細胞運動 / 電子顕微鏡 / 一分子計測 / 病原細菌 / 構造生物学 / 電子線クライオトモグラフィー / 寄生細菌 / 急速レプリカ法 / 電子線 / 急速凍結レプリカ法 / マイコプラズマ / 滑走運動 / 滑走装置 / 分子形態 / 高速AFM / 結晶化 / クライオ電子線トモグラフィー |
|---|
| Outline of Final Research Achievements |
Mycoplalasma pneumonia, epidemic recent years is caused by a bacterium, Mycoplasma pneumoniae. Mycoplasmas glide by quite unique mechanisms, which are essential for infection. In this project, we studied the fasest species, Mycoplasma mobile and the pathogenic Mycoplasma pneumoniae and got the following results, (1) namometer-order three dimensional structure of gliding machinery, (2) identification, detecting activity and outline of structure, for essential proteins, (3) ATPase reaction of gliding machinery, (4) behaviors of “leg” molecule, (5) development of gene manipulation method and localization of gliding proteins.
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Report
(5 results)
Research Products
(64 results)
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[Presentation] 滑走するマイコプラズマ2014
Author(s)
宮田真人
Organizer
第7回ニコニコ学会βシンポジウム
Place of Presentation
ニコファーレ（東京都・港区）
Year and Date
2014-12-20
Related Report
Invited
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[Presentation] マイコプラズマ運動三種盛り2014
Author(s)
宮田真人
Organizer
理研シンポジウム 第4回分子モーター討論会
Place of Presentation
大阪大学(大阪府・吹田市)
Year and Date
2014-06-27 – 2014-06-28
Related Report
Invited
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[Book] 最新マイコプラズマ学2016
Author(s)
神谷 茂, 泉川欣一, 賀来満男, 佐々木次雄, 難波成任, 宮田真人, 大島研郎, 柿澤茂行, 見理 剛, 佐々木裕子, 佐藤静夫, 皿谷 健, 柴田健一郎, 清水 隆, 田中裕士, 原澤 亮, 堀野敦子, 松田和洋, 柳原 格, 渡邉秀裕(ほか37名）
Total Pages
259
Publisher
近代出版
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