Genetic analysis of mechanisms for spontaneous activities in the C. elegans central nervous system
| Project/Area Number |
24570009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Kyushu University |
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Principal Investigator |
TERAMOTO Takayuki 九州大学, 理学(系)研究科(研究院), 准教授 (90571836)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIHARA Takeshi 九州大学, 理学研究院生物, 教授 (10249948)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | カルシウムイメージング / 神経 / 線虫 |
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| Outline of Final Research Achievements |
The central nervous system generates spontaneous activities, which are thought to contribute to information processing; however, its function is not fully understood. In this study, to reveal its nature, we performed whole-brain imaging of C. elegans at cellular resolution by using 4D imaging system that we have designed and developed. Analysis of temporal changes in ratio of the individual neurons revealed a synchronized rhythmic activity in multiple neurons under non-stimulus condition. By frequency analysis indicated a major component is close to rhythm of switching forward-backward locomotion, implying that the rhythm component may function as a pacemakers or pattern generators for the locomotion. On the other hand, a gap-junction coding gene inx-7 mutation reduced spontaneous activity, implying gap-junctions may be involved in the pacemaker.
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Report
(4 results)
Research Products
(15 results)
