| Project/Area Number |
24580170
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tohoku University |
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Principal Investigator |
NAKAGAWA Kiyotaka 東北大学, (連合)農学研究科(研究院), 准教授 (80361145)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAWA Teruo 東北大学, 大学院農学研究科, 教授 (20157639)
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| Co-Investigator(Renkei-kenkyūsha) |
ARAI Hiroyuki 東北大学, 加齢医学研究所, 教授 (30261613)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 過酸化脂質 / miRNA / アミロイドβ / キサントフィル / アルツハイマー / バイオマーカー / 食品科学 / アルツハイマｰ / バイオマーカｰ |
|---|
| Outline of Final Research Achievements |
It is desired to develop biomarkers for Alzheimer's disease (AD), in order to readily start AD prevention. In this study, we found changes of phospholipid peroxides, xanthophyll and amyloid β levels in red blood cells of AD patients, indicating their usability for AD biomarkers. We obtained microRNA (miRNA) profile by analyzing AD plasma and cerebrospinal fluid, and selected potential miRNA useful for AD biomarkers. In addition, effects of food ingredients (e.g., lutein) capable of regulating these AD biomarkers were evaluated. The present results will lead to AD prevention and discovery of new food function.
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