| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Human carboxylesterase (CES), butyrylcholinesterase (BuChE), arylacetamido deacetylase (AADAC), cholesteroesterase(ChlE) and paraoxonase (PON) efficiently catalyze the hydrolysis of a variety of ester- and amide-containing chemicals as well as drug to the respective free acid. These hydrolases catalyze the hydrolysis of the different structure of clinically used pro-drugs. In this study, we investigated the tissue specific expression and the structure activity relationship of pro-drugs of these hydrolase enzymes.
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