| Project/Area Number |
24591346
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kinki University |
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Principal Investigator |
BABAYA Naru 近畿大学, 医学部, 講師 (10449837)
|
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| Co-Investigator(Kenkyū-buntansha) |
IKEGAMI Hiroshi 近畿大学, 医学部, 教授 (20221062)
KAWABATA Yumiko 近畿大学, 医学部, 准教授 (80423185)
NOSO Shinsuke 近畿大学, 医学部, 講師 (90460849)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 糖尿病疾患感受性遺伝子 / 糖尿病 / 疾患感受性遺伝子座 / NSYマウス / コンソミックマウス / コンジェニックマウス / 相互作用 |
|---|
| Outline of Final Research Achievements |
Type 2 diabetes are multifactorial diseases caused by a complex interaction of environmental and genetic factors, with the latter consisting of multiple susceptibility genes, making it difficult to clarify their functions and interactions in conferring susceptibility to type 2 diabetes in humans. In this study, we constructed consomic and congenic strains, in which the NSY-derived diabetogenic region was introgressed onto the genetic background of control mice. We succeeded to localize and characterize the function of diabetogenic region in the NSY.
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