The strategy for elucidation of diabetogenic factors:functional partition and reintegrate
| Project/Area Number |
24591346
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kinki University |
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Principal Investigator |
BABAYA Naru 近畿大学, 医学部, 講師 (10449837)
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| Co-Investigator(Kenkyū-buntansha) |
IKEGAMI Hiroshi 近畿大学, 医学部, 教授 (20221062)
KAWABATA Yumiko 近畿大学, 医学部, 准教授 (80423185)
NOSO Shinsuke 近畿大学, 医学部, 講師 (90460849)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 糖尿病疾患感受性遺伝子 / 糖尿病 / 疾患感受性遺伝子座 / NSYマウス / コンソミックマウス / コンジェニックマウス / 相互作用 |
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| Outline of Final Research Achievements |
Type 2 diabetes are multifactorial diseases caused by a complex interaction of environmental and genetic factors, with the latter consisting of multiple susceptibility genes, making it difficult to clarify their functions and interactions in conferring susceptibility to type 2 diabetes in humans. In this study, we constructed consomic and congenic strains, in which the NSY-derived diabetogenic region was introgressed onto the genetic background of control mice. We succeeded to localize and characterize the function of diabetogenic region in the NSY.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Association study of MAFA and MAFB, genes related to organ-specific autoimmunity, with susceptibility to type 1 diabetes in Japanese and Caucasian populations.2013
Author(s)
Noso S, Kawabata Y, Babaya N, Hiromine Y, Kawasaki E, Awata T, Maruyama T, Sunanda B, Oiso N, Kawada A, Suzuki T, Eisenbarth GS, Ikegami H
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Journal Title
Journal of Genetic Syndromes & Gene Therapy
Volume: 4
Pages: 204-204
DOI
Related Report
Peer Reviewed
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[Journal Article] A low-frequency GLIS3 variant associated with resistance to Japanese type 1 diabetes.se chromosome 11.2013
Author(s)
Awata T, Yamashita H, Kurihara S, Morita-Ohkubo T, Miyashita Y, Katayama S, Kawasaki E, Tanaka S, Ikegami H, Maruyama T, Shimada A, Takahashi K, Kawabata Y, Kobayashi T, Nishida N, Mawatari Y.
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Journal Title
Biochem Biophys Res Commun.
Volume: 437
Pages: 521-5
DOI
Related Report
Peer Reviewed
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[Journal Article] Report of the Committee of the Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus: New Diagnostic Criteria of Fulminant Type 1 Diabetes Mellitus (2012)2012
Author(s)
Imagawa A, Hanafusa T, Awata T, Ikegami H, Uchigata Y, Osawa H, Kawasaki E, Kawabata Y, Kobayashi T, Shimada A, Shimizu I, Takahashi K, Nagata M, Makino H, Maruyama T
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Journal Title
Diabetol Int.
Volume: 3
Pages: 179-179
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Low Expression of PD-1 in Peripheral CD4+ T-cells in Japanese Patients with Type 1A Diabetes.2013
Author(s)
Fujisawa R, Haseda F, Tsutsumi C, Hiromine Y, Noso S, Kawabata Y, Mitsui S, Terasaki J, Ikegami H, Imagawa A, Hanafusa T
Organizer
73rd Scientific Session of America Diabetes Association
Place of Presentation
Chicago, USA
Related Report
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[Presentation] Low expression level of Peripheral CD4+PD-1+T-cells in Japanese Patients with Type 1A Diabetes.2013
Author(s)
Fujisawa R, Haseda F, Tsutsumi C, Hiromine Y, Noso S, Kawabata Y, Mitsui S, Terasaki J, Ikegami H, Imagawa A, Hanafusa T
Organizer
13th International Congress of the Immunology of Diabetes
Place of Presentation
Lorne, Australia
Related Report
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[Presentation] Association of a functional polymorphism MAFA Gly346Cys with susceptibility to type 1 diabetes.2012
Author(s)
Noso S, Kawabata Y, Babaya N, Hiromine Y, Kawasaki E, Awata T, Maruyama T, Babu S, Eisenbarth GS, Ikegami H
Organizer
12th International Congress of the Immunology of Diabetes Society
Place of Presentation
Victoria, Canada
Related Report
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