• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Fundamental and clinical study for the purpose of early diagnosis of multiple system atrophy

Research Project

Project/Area Number 24591763
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionTottori University

Principal Investigator

OGAWA Toshihide  鳥取大学, 医学部, 教授 (00125709)

Co-Investigator(Kenkyū-buntansha) FUJII Shinya  鳥取大学, 医学部附属病院, 講師 (10379638)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords多系統萎縮症 / MRI / 脳血流SPECT
Outline of Final Research Achievements

We retrospectively reviewed 28 patients with multiple system atrophy, cerebellar type (MSA-C) who underwent MRI and 99mTc-ECD SPECT and evaluated laterality of atrophy and signal changes on MRI, and laterality of perfusion on 99mTc-ECD SPECT. We also compared the latest MRI and SPECT findings. Laterality was identified for 64%, 61%, and 21% of atrophy in the cerebellum, MCP, and pons, respectively, on MRI and for 71% of atrophy in the cerebellum on perfusion SPECT. Concerning comparisons between the latest MRI and SPECT findings, laterality of cerebellar/MCP atrophy on MRI and decreased cerebellar perfusion on SPECT was matched in 57%, mismatched in 11%, and absent in 25% of patients. Including the latest and past images, asymmetrical changes were observed in 75% of patients.
Asymmetrical changes on MRI and perfusion SPECT are common in MSA-C patients. Perfusion SPECT is useful for diagnosing MSA-C in the early stages from a functional perspective.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (20 results)

All 2015 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 8 results,  Open Access: 3 results) Presentation (7 results) Book (4 results)

  • [Journal Article] High incidence of asymptomatic cerebral microbleeds in patients with hemorrhagic onset-type moyamoya disease: a phase-sensitive MRI study and meta-analysis.2015

    • Author(s)
      Qin Y, Ogawa T, Fujii S, Shinohara Y, Kitao S, Miyoshi F, Takasugi M, Watanabe T, Kaminou T.
    • Journal Title

      Acta Radiol

      Volume: 56 Issue: 3 Pages: 329-338

    • DOI

      10.1177/0284185114524198

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serial 3 T magnetic resonance imaging during cabergoline treatment of macroprolactinomas.2015

    • Author(s)
      Kurosaki M, Kambe A, Watanabe T, Fujii S, Ogawa T.
    • Journal Title

      Neurol Res

      Volume: 27 Pages: 341-346

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CT angiography after carotid artery stenting: assessment of the utility of adaptive statistical iterative reconstruction and model-based iterative reconstruction.2014

    • Author(s)
      Kuya K, Shinohara Y, Sakamoto M, Iwata N, Kishimoto J, Fujii S, Kaminou T, Watanabe T, Ogawa T.
    • Journal Title

      Neuroradiology

      Volume: 56 Issue: 11 Pages: 1015-1023

    • DOI

      10.1007/s00234-014-1415-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of monochromatic imaging with metal artifact reduction software for computed tomography angiography after intracranial aneurysm coil embolization.2014

    • Author(s)
      Shinohara Y, Sakamoto M, Iwata N, Kishimoto J, Kuya K, Fujii S, Kaminou T, Watanabe T, Ogawa T.
    • Journal Title

      Acta Radiol

      Volume: 55 Issue: 8 Pages: 1015-1023

    • DOI

      10.1177/0284185113510492

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evalution of Parkinson disease and Alzheimer disease with the use of neuromelanin MR imaging and 123 I-metaiodobenzylguanidine scintigraphy2013

    • Author(s)
      Miyoshi M, Ogawa T, Kitao S, Kitayama M, Shinohara Y, Takasugi S, Fujii S, Kaminou T
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: 34 Issue: 11 Pages: 2113-2118

    • DOI

      10.3174/ajnr.a3567

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Radiation-induced microbleeds after cranial irradiation:evaluation by phase-sensitive magnetic resonance imaging with 3.0 tesla2013

    • Author(s)
      Tanino T, Kanasaki Y, Tahara T, Michimoto K, Kodani K, Kimihiko S, Kaminou T, Watanabe T, Ogawa T
    • Journal Title

      Yonago Acta medica

      Volume: 56 Pages: 7-12

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 3D ASLにて再灌流治療前後でのcrossed cerebellar diaschisisを指摘し得た急性期脳塞栓症の1例2013

    • Author(s)
      加藤亜結美、篠原祐樹、坂本 誠、宇野哲史、藤井進也、神納敏夫、渡辺高志、小川敏英
    • Journal Title

      臨床放射線

      Volume: 58 Pages: 1375-1380

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significance of apparent diffusion coefficient measurement for the differential diagnosis of multiple system atrophy, progressive supranuclear palsy, and Parkinson’s disease: evaluation by 3.0-T MR imaging2012

    • Author(s)
      Tsukamoto K, Matsusue E, Kanasaki Y, Kakite S, Fujii S, Kaminou T, Ogawa T
    • Journal Title

      Neuroradiology

      Volume: 54 Issue: 9 Pages: 947-955

    • DOI

      10.1007/s00234-012-1009-9

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 3T MRIの脳血管障害および神経変性疾患への臨床応用2012

    • Author(s)
      篠原祐樹、松末英司、藤井進也、金﨑佳子、高杉麻利恵、北尾慎一郎、三好史倫、久家圭太、山下栄二郎、神納敏夫、小川敏英
    • Journal Title

      映像情報メディカル

      Volume: 44 Pages: 640-643

    • Related Report
      2012 Research-status Report
  • [Presentation] Evaluation of multiple system atrophy-cerebellar type with the use of MR imaging and perfusion SPECT2014

    • Author(s)
      Miyoshi F, Kanasaki Y, Shinohara Y, Fujii S, Ogawa T
    • Organizer
      20th Symposium Neuroradiologicum
    • Place of Presentation
      イスタンブール(トルコ)
    • Year and Date
      2014-09-07 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] MSA-Cの左右差に関するMRIと脳血流SPECTを用いた検討2014

    • Author(s)
      三好史倫、金崎佳子、篠原祐樹、北尾慎一郎、藤井進也、神納敏夫、小川敏英
    • Organizer
      第43回日本神経放射線学会
    • Place of Presentation
      米子コンベンションセンター、米子市
    • Related Report
      2013 Research-status Report
  • [Presentation] Significance of combined use of MR imaging and perfusion SPECT for the evaluation of multiple system atrophy2013

    • Author(s)
      Ogawa T, Kanasaki Y, Fujii S, Shinohara Y, Kaminou T, Miyoshi F
    • Organizer
      37th Annual Meeting of European Society of Neuroradiology
    • Place of Presentation
      Goethe University、Frankfurt
    • Related Report
      2013 Research-status Report
  • [Presentation] MSA-Cの左右差に関するMRIと脳血流SPECTを用いた検討2013

    • Author(s)
      三好史倫、篠原祐樹、北尾慎一郎、太田靖利、杉浦公彦、神納敏夫、小川敏英
    • Organizer
      第121回日本医学放射線学会中国・四国地方会
    • Place of Presentation
      かがわ国際会議場、高松市
    • Related Report
      2013 Research-status Report
  • [Presentation] Evaluation of Parkinson’s disease and Alzheimer’s disease using neuromelanin magnetic resonance imaging and 123I-metaiodobenzylguanidine scintigraphy2013

    • Author(s)
      Miyoshi F, Ogawa T, Kitao S, Kitayama M, Shinohara Y, Takasugi M, Fujii S, Kaminou T
    • Organizer
      European Congress of Radiology
    • Place of Presentation
      Austria Center Vienna
    • Related Report
      2012 Research-status Report
  • [Presentation] Correlation between pathology and neuromelanin MR imaging in Parkinson's disease and dementia with Lewy bodies2013

    • Author(s)
      Kitao S, Matsusue E, Miyoshi F, Fujii S, Kaminou T, Ogawa T
    • Organizer
      European Congress of Radiology
    • Place of Presentation
      Austria Center Vienna
    • Related Report
      2012 Research-status Report
  • [Presentation] 変性疾患(MSA, PSP, PD)の鑑別におけるADC値測定の意義:3 tesla MRI を用いた検討2012

    • Author(s)
      塚本和充、松末英司、福永 健、柿手 卓、仲松 暁、藤井進也、金崎佳子、神納敏夫、小川敏英
    • Organizer
      第71回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Book] Alzheimer型認知症 頭部疾患画像アトラス2014

    • Author(s)
      三好史倫、篠原祐樹、小川敏英
    • Total Pages
      4
    • Publisher
      羊土社
    • Related Report
      2013 Research-status Report
  • [Book] 前頭側頭葉変性症 頭部疾患画像アトラス2014

    • Author(s)
      三好史倫、篠原祐樹、小川敏英
    • Total Pages
      3
    • Publisher
      羊土社
    • Related Report
      2013 Research-status Report
  • [Book] Lewy小体型認知症 頭部疾患画像アトラス2014

    • Author(s)
      三好史倫、篠原祐樹、小川敏英
    • Total Pages
      4
    • Publisher
      羊土社
    • Related Report
      2013 Research-status Report
  • [Book] 頭部画像解剖 脳実質の構造-深部灰白質-2012

    • Author(s)
      高杉麻利恵、小川敏英
    • Publisher
      Medical View
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi