| Project/Area Number |
24615006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Regenerative medicine
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
北本 武郎 北里大学, 理学部, 助教 (20453516)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 筋肉 / 筋再生 / 筋成長 / Lbx1 / Notch3 / ノックアウトマウス / サテライト細胞 / 幹細胞 / 網羅的発現解析 / 細胞分裂 |
|---|
| Outline of Final Research Achievements |
In previous studies, we have found that Lbx1, the homeo-box transcription factor, and Notch3, a member of notch gene family, are expressed in satellite cells of skeletal muscles in mice. To address the potential postnatal functions of Lbx1, we analyzed phenotypic alterations that occurred in skeletal muscles of Lbx1 conditional knockout mice. The data obtained indicate Lbx1 plays critical roles not only in muscle regeneration but also in postnatal muscle growth, probably through activating proliferation of satellite cells.
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