| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Germ cells are the only cells that can carry genetic information on to the next generation. I focused on the male germ cell specific glycosylphosphatidylinositol (GPI)-anchored protein complexes, TEX101 and LY6K, and studied their physiological functions using gene-manipulated mice.
I showed that these GPI-anchored protein complexes are required for sperm migrating ability into the oviduct and subsequent male fertility (PNAS. 2013, BOR. 2014). TEX101 and LY6K protein complexes interacted with the sperm membrane protein ADAM3 in mouse testes. However, spermatozoa from LY6K-deficient mice had no aberrance in ADAM3. Thus, the no effect on ADAM3 in LY6K-deficient mice is indicative of an as yet undefined pathway in the mouse.
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