Mechanism of protective immunity against blood-stage malaria by CD8T cells.
| Project/Area Number |
24790399
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Gunma University |
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Principal Investigator |
IMAI Takashi 群馬大学, 医学(系)研究科(研究院), 助教 (10513434)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | マラリア / CD8 / マラリア原虫 / マクロファージ / 感染防御 / T細胞 / 赤芽球 / 赤内期 / 感染免疫 / CD8T細胞 / 貪食細胞 / 細胞傷害活性 / 防御免疫 |
|---|
| Research Abstract |
Mice depleted of CD8 T cells showed higher parasitemia and lower survival during infection with otherwise non-lethal blood-stage malaria parasites, indicating protective roles of CD8 T cells. However, how these cells mediate protection to blood-stage malaria parasites that infect red blood cells deficient in MHC class I expression is elusive. In this study, we found that erythroblasts, progenitor cells of red blood cells, are parasitized by malaria parasites, and parasitized erythroblasts were recognized by CD8 T cells in an antigen-specific manner, suggesting that parasitized erythroblasts are the target of CD8 T cell. We further explored protective mechanisms exerted by CD8 T cells. We revealed that phosphatidylserine was externalized on parasitized cells after a ligation of cytotoxic molecule FasL on CD8 T cells to Fas on the target cells, which leads to induce effective phagocytosis by macrophages.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] IL-23 protection against Plasmodium berghei infection in mice is partially dependent on IL-17 from macrophages2013
Author(s)
Ishida H, Imai T, Suzue K, Hirai M, Taniguchi T, Yoshimura A, Iwakura Y, Okada H, Suzuki T, Shimokawa C, and Hisaeda
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Journal Title
Eur. J. Immunol.
Volume: 43
Issue: 10
Pages: 2696-2706
DOI
Related Report
Peer Reviewed
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[Journal Article] Resistance to Malaria by Enhanced Phagocytosis of Erythrocytes in LMP7-deficient Mice.2013
Author(s)
Duan X, Imai T, Chou B, Tu L, Himeno K, Suzue K, Hirai M, Taniguchi T, Okada H, Shimokawa C, Hisaeda H.
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Journal Title
PLoS One.
Volume: 8
Issue: 3
Pages: 1-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Species-specific immunity induced by infection with Entamoeba histolytica and Entamoeba moshkovskii in mice2013
Author(s)
Shimokawa, C., Culleton, R., Imai, T., Suzue, K., Hirai, M., Taniguchi, T., Kobayashi, S., Hisaeda, H., Hamano, S
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Journal Title
PLoS One
Volume: 8(11)
Issue: 11
Pages: e82025-e82025
DOI
NAID
Related Report
Peer Reviewed
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