Epidemiological Study regarding to the development of fatty liver, metabolic abnormalities, and potential arteriosclerosis.

• Project/Area Number: 24790616
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Public health/Health science
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Kadowaki Sayaka 滋賀医科大学, 医学部, 客員助教 (60510344)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 潜在的動脈硬化 / 冠動脈石灰化 / 脂肪肝 / 飲酒量 / コホート研究 / 肝臓・脾臓CT値比 / 社会医学 / 非アルコール性脂肪肝 / メタボリックシンドローム

Outline of Final Research Achievements

Relationship between the development of coronary artery calcification and fatty liver was studied. Coronary artery calcification score (CAC score), liver/ spleen CT value ratio (LS ratio), and the amount of drinking were measured at a baseline survey and the follow-up survey.
Out of 1,112 people, 841 people joined the follow-up survey and were analyzed. Among 772 participants (91.8 %) without fatty liver, 57 participants (7.4%) newly developed fatty liver after an average of 4.9 years. BMI and triglyceride at the baseline survey had significant associated with the development of fatty liver. The amount of alcohol consumption had no significant association with the fatty liver development. CAC score development had significant association with age, alcohol consumption, systolic blood pressure, and LDL cholesterol. LS ratio of the baseline survey had no significant association with the CAC score development.

Research Products

• [Journal Article] Lipoprotein-associated phospholipase A2 related to the risk of subclinical atherosclerosis independent of small low density lipoprotein particles in a general Japanese population. (2016)
  • Author(s): Ueshima H, Kadowaki T, Fujiyoshi A, Miura K, Ohkubo T, Kadota A, Kadowaki S, Nakamura Y, Miyagawa N, Okamura T, Kita Y, Takashima N, Kashiwagi A, Maegawa H, Horie M, Yamamoto T, et ai.
  • Journal Title: Athelosclerosis Volume: 246 Pages: 141-147
  • DOI: 10.1016/j.atherosclerosis.2015.12.027
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification (2016)
  • Author(s): Zaid M, Miura K, Fujiyoshi A, Abboot RD, Hisamatsu T, Kadota A, Arima H, Kadowaki S, Torii S, Miyagawa N, Suzuki S, Takashima N, Ohkubo T, Sekikawa A, Maegawa H, Horie M, Nakamura Y, Okamura T, Ueshima H.
  • Journal Title: J Clin Lipidol Volume: 未定
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between Pulse Wave Velocity and Coronary Artery Calcification in Japanese men (2015)
  • Author(s): Torii S, Arima H, Ohkubo T, Fujiyoshi A, Kadota A, Takashima N, Kadowaki S, Hisamatsu T, Saito Y, Miyagawa N, Zaid M, Murakami Y, Abbott R, Horie M, Miura K, Ueshima H.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Issue: 12 Pages: 1266-1277
  • DOI: 10.5551/jat.30247
  • NAID: 130005112368
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations between Inflammatory Markers and Subclinical Atherosclerosis in Middle-aged White, Japanese-American and Japanese Men: The ERA-JUMP Study (2015)
  • Author(s): Nagasawa SY, Ohkubo T, Masaki K, Barinas-Mitchell E, Miura K, Seto TB, El-Saed A, Kadowaki T, Willcox BJ, Edmundowicz D, Kadota A, Evans RW, Kadowaki S, Fujiyoshi A, Hisamatsu T, Bertolet MH, Okamura T, Nakamura Y, Kuller LH, Ueshima H, Sekikawa A.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Issue: 6 Pages: 590-598
  • DOI: 10.5551/jat.23580
  • NAID: 130004704379
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Ectopic cardiovascular fat in middle-aged men: effects of race/ethnicity, overall and central adiposity. The ERA JUMP study. (2015)
  • Author(s): El Khoudary SR, Shin C, Masaki K, Miura K, Budoff M, Edmundowicz D, Kadowaki S, Barinas-Mitchell E, El-Saed A, Fujiyoshi A, Evans RW, Hisamatsu T, Ohkubo T, Willcox BJ, Kuller LH, Ueshima H, Sekikawa A; ERA JUMP Study Group.
  • Journal Title: Int J Obes (Lond) Volume: 39 Issue: 3 Pages: 488-94
  • DOI: 10.1038/ijo.2014.154
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men (2015)
  • Author(s): Maryam Zaid, Akira Fujiyoshi, Katsuyuki Miura, Robert D. Abbott, Tomonori Okamura, Naoyuki Takashima, Sayuki Torii, Yoshino Saito, Takashi Hisamatsu, Naoko Miyagawa, Takayoshi Ohkubo, Aya Kadota, Akira Sekikawa, Hiroshi Maegawa, Yasuyuki Nakamura, Kenichi Mitsunami, Hirotsugu Ueshima, For the SESSA Research group
  • Journal Title: Atherosclerosis Volume: 239 Issue: 2 Pages: 444-450
  • DOI: 10.1016/j.atherosclerosis.2015.01.031
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comparison of HOMA-IR, HOMA-β% and disposition index between US white men and Japanese men in Japan: the ERA JUMP study. (2015)
  • Author(s): Ahuja V, Kadowaki T, Evans RW, Kadota A, Okamura T, El Khoudary SR, Fujiyoshi A, Barinas-Mitchell EJ, Hisamatsu T, Vishnu A, Miura K, Maegawa H, El-Saed A, Kashiwagi A, Kuller LH, Ueshima H, Sekikawa A; ERA JUMP Study Group.
  • Journal Title: Diabetologia Volume: 58 Issue: 2 Pages: 265-71
  • DOI: 10.1007/s00125-014-3414-6
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Brachial-ankle pulse wave velocity is associated with coronary calcification among 1131 healthy middle-aged men. (2015)
  • Author(s): Vishnu A, Choo J, Wilcox B, Hisamatsu T, Barinas-Mitchell EJ, Fujiyoshi A, Mackey RH, Kadota A, Ahuja V, Kadowaki T, Edmundowicz D, Miura K, Rodriguez BL, Kuller LH, Shin C, Masaki K, Ueshima H, Sekikawa A; ERA JUMP Study Group.
  • Journal Title: Int J Cardiol Volume: 189 Pages: 67-72
  • DOI: 10.1016/j.ijcard.2015.04.020
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Associations between Inflammatory Markers and Subclinical Atherosclerosis in Middle-aged White, Japanese-American and Japanese Men: The ERA-JUMP Study. (2014)
  • Author(s): Nagasawa SY, Ohkubo T, Masaki K, Barinas-Mitchell E, Miura K, Seto TB, El-Saed A, Kadowaki T, Willcox BJ, Edmundowicz D, Kadota A, Evans RW, Kadowaki S, Fujiyoshi A, Hisamatsu T, Bertolet MH, Okamura T, Nakamura Y, Kuller LH, Ueshima H, Sekikawa A.
  • Journal Title: J Atheroscler Thromb Volume: 9999 Pages: 9999-9999
  • NAID: 130004704379
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cross-sectional comparison of coronary artery calcium scores between Caucasian men in the United States and Japanese men in Japan: the multi-ethnic study of atherosclerosis and the Shiga epidemiological study of subclinical atherosclerosis. (2014)
  • Author(s): Fujiyoshi A, Miura K, Ohkubo T, Kadowaki T, Kadowaki S, Zaid M, Hisamatsu T, Sekikawa A, Budoff MJ, Liu K, Ueshima H; SESSA Research Group; MESA Research Group.
  • Journal Title: Am J Epidemiol Volume: 180 Issue: 6 Pages: 590-8
  • DOI: 10.1093/aje/kwu169
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population (2014)
  • Author(s): Takashi Hisamatsu、Akira Fujiyoshi、Katsuyuki Miura、Takayoshi Ohkubo、Aya Kadota、 Sayaka Kadowaki、Takashi Kadowaki、Takashi Yamamoto、Naoko Miyagawa、Maryam Zaid、Sayuki Torii、Naoyuki Takashima、Yoshitaka Murakami、Tomonori Okamura、Minoru Horie、Hirotsugu Ueshima; for the SESSA Research Group
  • Journal Title: Atherosclerosis Volume: 236 Issue: 2 Pages: 237-243
  • DOI: 10.1016/j.atherosclerosis.2014.07.019
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Long chain n-3 polyunsaturated fatty acids and incidence rate of coronary artery calcification in Japanese men in Japan and white men in the USA: population based prospective cohort study (2014)
  • Author(s): Akira Sekikawa, Katsuyuki Miura, Sunghee Lee, Akira Fujiyoshi, Hirotsugu Ueshima, et al.
  • Journal Title: Heart Volume: 100 Issue: 7 Pages: 569-573
  • DOI: 10.1136/heartjnl-2013-304421
  • Peer Reviewed
• [Journal Article] Ethnic difference in liver fat content: a cross-sectional observation among Japanese American in Hawaii, Japanese in Japan, and non-Hispanic whites in United States. (2013)
  • Author(s): Azuma K, Curb JD, Kadowaki T, Edmundowicz D, Kadowaki S, Masaki KH, El-Saed A, Nishio Y, Seto TB, Okamura T, Cetinel C, Kadota A, Sutton-Tyrrell K, Miura K, Evans RW, Takamiya T, Maegawa H, Miljkovic I, Kuller LH, Ueshima H, Kelley DE, Sekikawa A.
  • Journal Title: Obesity Research & Clinical Practice Volume: 7 Issue: 3 Pages: 198-205
  • DOI: 10.1016/j.orcp.2011.11.007
  • Peer Reviewed
• [Journal Article] A cross-sectional association of obesity with coronary calcium among Japanese, Koreans, Japanese Americans, and US Whites (2013)
  • Author(s): Akira Fujiyoshi, Akira Sekikawa, Chol Shin, Hirotsugu Ueshima, et al.
  • Journal Title: European Heart Journal Cardiovascular Imaging Volume: 14 Issue: 9 Pages: 921-927
  • DOI: 10.1093/ehjci/jet080
  • NAID: 120005713796
  • Peer Reviewed
• [Presentation] Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification beyond Metabolic Syndrome in a General Population: Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2016)
  • Author(s): Masahiro Yamazoe, Takashi Hisamatsu, Katsuyuki Miura, Sayaka Kadowaki, Maryam Zaid, Aya Kadota, Takashi Kadowaki, Akira Fujiyoshi, Robert Abbott, Hisatomi Arima, Akira Sekikawa, Hiroshi Maegawa, Minoru Horie, Hirotsugu Ueshima, for the SESSA Research Group
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] Which Factors Predict Longitudinal Change of Pericardial Fat Volume in Japanese Men? : Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2016)
  • Author(s): Itsuko Miyazawa, Takayoshi Ohkubo, Sayaka Kadowaki, Akira Fujiyoshi, Takashi Hisamatsu, Aya Kadota, Hisatomi Arima, Katsuyuki Miura, Hiroshi Maegawa, Hirotsugu Ueshima, for the SESSA Research Group
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] Is Home Blood Pressure More Strongly Associated With Coronary Artery Calcification Than Clinic Blood Pressure Measured Under An Ideal Condition? (2016)
  • Author(s): Atsushi Satoh, Hisatomi Arima, Atsushi Hozawa, Takashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Akira Fujiyoshi, Naoko Miyagawa, Maryam Zaid, Sayuki Torii, Takayoshi Ohkubo, Tomonori Okamura, Akira Sekikawa, Katsuyuki Miura, Hirotsugu Ueshima, SESSA research group
  • Organizer: AHA EPI Lifestyle 2016
  • Place of Presentation: Phoenix
  • Year and Date: 2016-03-01
• [Presentation] 日本人一般男性集団において冠動脈石灰化の同定に最適なbaPWVのカットオフ値：SESSA (2016)
  • Author(s): 鳥居さゆ希、有馬久富、門田文、久松隆史、門脇紗也佳、鈴木仙太朗、高嶋直敬、藤吉朗、大久保孝義、三浦克之、上島弘嗣
  • Organizer: 第15回臨床血圧脈波研究会
  • Place of Presentation: 大阪
  • Year and Date: 2016-01-21
• [Presentation] 喫煙習慣、喫煙指数、禁煙期間と潜在性動脈硬化との関連：滋賀動脈硬化疫学研究SESSA (2016)
  • Author(s): 久松隆史、三浦克之、有馬久富、門脇紗也佳、鳥居さゆ希、鈴木仙太朗、宮川尚子、門田文、藤吉朗、大久保孝義、上島弘嗣
  • Organizer: 第26回日本疫学会学術総会
  • Place of Presentation: 米子
  • Year and Date: 2016-01-21
• [Presentation] 家庭血圧は理想的環境下で測定した診察室血圧より冠動脈石灰化と強く関連するか？：Shiga Epidemiological Study of Subclinical Atherosclerosis（SESSA） (2015)
  • Author(s): 佐藤敦、有馬久富、寳澤 篤、久松隆史、門脇 紗也佳、門田 文、藤吉 朗、宮川 尚子、Maryam Zaid、鳥居 さゆ希、大久保 孝義、岡村 智教、関川 暁、三浦 克之、上島 弘嗣、SESSAグループ
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: 愛媛
  • Year and Date: 2015-10-09
• [Presentation] LDL particle count is a robust marker for carotid intima-media thickness and coronary artery calcification (2015)
  • Author(s): Maryam Zaid, Takashi Hisamatsu, Akira Fujiyoshi, Aya Kadota, Hisatomi Arima, Robert D. Abbott, Sayaka Kadowaki, Sayuki Torii, Naoko Miyagawa, Sentaro Suzuki, Naoyuki Takashima, Takayoshi Ohkubo, Akira Sekikawa, Minoru Horie, Yasuyuki Nakamura, Katsuyuki Miura, Hirotsugu Ueshima, for the SESSA Research group
  • Organizer: 第51回日本循環器病予防学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-06-26
• [Presentation] Association of Major and Minor ECG Abnormalities with Subclinical Atherosclerosis in a General Japanese Population: SESSA (2015)
  • Author(s): Takashi Hisamatsu, Katsuyuki Miura, Akira Fujiyoshi, Sayaka Kadowaki, Maryam Zaid, Sayuki Torii, Aya Kadota, Yasuyuki Nakamura, Minoru Horie, Hirotsugu Ueshima; for the SESSA Research Group
  • Organizer: 第79回日本循環器学会学術集会・総会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24
• [Presentation] 動脈硬化指標と過活動膀胱との関連についての検討 (2014)
  • Author(s): 水流 輝彦, 荒木 勇雄, 門脇 紗也佳, 久松 隆史, 藤吉 朗, 河内 明宏, 三浦 克之, 上島 弘嗣
  • Organizer: 第21回日本排尿機能学会
  • Place of Presentation: 岡山
  • Year and Date: 2014-09-17 – 2014-09-20
• [Presentation] Association of Major and Minor ECG Abnormalities with Subclinical Atherosclerosis in a General Japanese Population: SESSA (2014)
  • Author(s): Takashi Hisamatsu, Katsuyuki Miura, Akira Fujiyoshi, Sayaka Kadowaki, Maryam Zaid, Sayuki Torii, Aya Kadota, Yasuyuki Nakamura, Minoru Horie, Hirotsugu Ueshima; for the SESSA Research Group
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] Association between Pulse Wave Velocity and Coronary Artery Calcification in general Japanese men: Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2013)
  • Author(s): Sayuki Torii
  • Organizer: 第81回欧州動脈硬化学会
  • Place of Presentation: フランス リヨン
• [Presentation] 高齢男性における慢性腎臓病と認知機能との関連の検討：滋賀潜在性動脈硬化研究 (2013)
  • Author(s): 藤吉朗
  • Organizer: 第49回日本循環器病予防学会
  • Place of Presentation: 金沢市文化ホール
• [Presentation] 日本人男性における心臓周囲脂肪と肥満指標との関連：滋賀潜在性動脈硬化研究(SESSA) (2013)
  • Author(s): 宮澤伊都子
  • Organizer: 第49回日本循環器病予防学会
  • Place of Presentation: 金沢市文化ホール
• [Presentation] 日本人一般男性集団における脈波伝播速度と頸動脈内膜中膜肥厚および頸動脈プラークとの関連: Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2013)
  • Author(s): 鳥居さゆ希
  • Organizer: 第45回日本動脈硬化学会
  • Place of Presentation: 新宿
• [Presentation] 地域住民男性における生涯喫煙量と内臓脂肪との関連：SESSA研究 (2013)
  • Author(s): 藤吉朗
  • Organizer: 第34回日本肥満学会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] Lifetime Cigarette Smoking is Associated with Increased Indices of Abdominal Obesity Independent of Body Mass Index: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2013)
  • Author(s): Akira Fujiyoshi
  • Organizer: AHA Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2014 Scientific Sessions
  • Place of Presentation: アメリカ合衆国 サンフランシスコ