| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
Fungus is one of rare pathogens but causes intractable infections when they occur in immunocompromised patients. Antifungal agents are limited and combination with some other drugs might modulate its antifungal activity. We showed that anti-pyretic agents, cyclooxygenase (cox) inhibitors, attenuated the antifungal activity. We analyzed how cox inhibitors attenuated the antifungal activity and suggested that cox inhibitors induced an efflux pump which pump out some antifungal agents. This result could be a clue to invent new strategies against fungal infections.
|
