Research Project
Grant-in-Aid for Young Scientists (B)
We investigated the relationship between cell invasion and irradiation. Human glioblastoma (GBM) cell lines were irradiated with X-rays or carbon ion beams(C-ions). Not only X-rays but C-ions irradiation increased cell motility at 24 hours after irradiation. C-ions irradiated cells were more migrative than X-rays irradiated cells. Increase of cell migration by irradiation was linear energy transfer (LET)-independent manner.Suppression of O6-methylguanine-DNA methyltransferase (MGMT) expression increased migration of GBM cells. These results suggest that depletion of MGMT is associated with increased cell migration.
All 2015 2014 2013 2012 Other
All Journal Article (11 results) (of which Peer Reviewed: 11 results, Open Access: 3 results, Acknowledgement Compliant: 1 results) Presentation (14 results) (of which Invited: 3 results) Book (1 results)
J Radiat Res.
Volume: 56 Issue: 2 Pages: 229-238
10.1093/jrr/rru085
Radiat Res.
Volume: 182 Issue: 3 Pages: 338-344
10.1667/rr13782.1
PLoS One
Volume: 9 Issue: 12 Pages: e115121-e115121
10.1371/journal.pone.0115121
120006986291
Exp Ther Med.
Volume: 8 Pages: 754-758
Volume: 55 Issue: 4 Pages: 658-664
10.1093/jrr/rru002
Volume: 55 Issue: 4 Pages: 665-673
10.1093/jrr/rru005
J Radiat Res
Volume: 印刷中
Volume: 179 Issue: 6 Pages: 630-6
10.1667/rr3098.1
Volume: 53 Pages: 87-92
10030023646
Volume: 53 Pages: 545-550