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Development of a new PET probe for apoptosis

Research Project

Project/Area Number 24791351
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Matsumoto Yasuko  国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究, 客員研究員 (10612187)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsアポトーシス / Tim4 / PET / ヒトT細胞免疫グロブリンムチン蛋白質‐4 / ホスファチジルセリン
Outline of Final Research Achievements

In this study, we developed a new PET probe which based on Tim4 protein for detecting apoptosis. To develop new PET probe for PS, we designated the fusion protein composed of extracellular region of mouse Tim4 and human IgG-Fc region, named Tim4-Fc. [64Cu] Tim4-184-Fc was evaluated in mouse xenograft model bearing human epithelial carcinoma A431. PET experiments showed that its tumor accumulation was 4 times higher in MitomycinC (MMC) treated mice than in non-treated mice.
Next, we tried to convert mouse Tim4 into human Tim4 for clinical use. However, PS binding ability of [64Cu] hTim4-187-Fc has lower than [64Cu]Tim4-184-Fc. In PET experiment, we could not observed difference of RI accumulation to tumor between MMC treated mice and control mice.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2014 2013 2012

All Presentation (2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Presentation] Imaging of Apoptosis using Cu-64 T-cell immunoglobulin mucin 4-Fc2014

    • Author(s)
      Yasuko Matsumoto, Chinuyo Sumita, Yasuhiro Wada, Emi Hayashinaka, Shigekazu Nagata, and Yasuyoshi Watanabe
    • Organizer
      2014 World Molecular Imaging Congress
    • Place of Presentation
      韓国 ソウル
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] [64Cu]T-cell immunoglobulin mucin 4-Fcによる細胞死の検出2012

    • Author(s)
      松本恭子、角田ちぬよ、林中恵美、和田康弘、長田重一、渡辺恭良
    • Organizer
      第7 回日本分子イメージング学会総会・学術集会
    • Place of Presentation
      静岡県 浜松市
    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 死細胞の検出用プローブ2013

    • Inventor(s)
      松本恭子、渡辺恭良、角田ちぬよ
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-109917
    • Filing Date
      2013
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] PROBE FOR DETECTING DEAD CELL2013

    • Inventor(s)
      松本恭子、渡辺恭良、角田ちぬよ
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013
    • Related Report
      2013 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] 特許願2012

    • Inventor(s)
      松本恭子、渡辺恭良、角田ちぬよ
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-256679
    • Filing Date
      2012
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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