| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Outline of Final Research Achievements |
Immature oocytes arrest at the G2/M-phase border, and the maturation-inducing hormone stimulates release of this arrest via activation of cyclin B-Cdk1, the M-phase governor. Here we investigated the intracellular signal transduction mechanism underlying this release of the cell cycle arrest. We identified molecular components of the binding protein of the maturation-inducing hormone which is located on the oocyte surface. We further revealed the presence of the self-calming system that cancels the stimulus of insufficient levels of maturation-inducing hormone, leading to prevention of an unexpected activation of cyclin B-Cdk1.
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