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MUC21 glycoforms as the target of cancer diagnosis and therapy

Research Project

Project/Area Number 25293011
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionJuntendo University (2016)
St. Luke's International University (2014-2015)
The University of Tokyo (2013)

Principal Investigator

IRIMURA Tatsuro  順天堂大学, 医学部, 特任教授 (80092146)

Co-Investigator(Kenkyū-buntansha) 伝田 香里  順天堂大学, 医学部, 助教 (00313122)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywordsムチン / 乳腺がん / 治療抵抗性 / モノクローナル抗体 / グライコフォーム / MUC21 / 腫瘍マーカー / 乳がん / 糖鎖 / がん / アポトーシス / 抗がん剤
Outline of Final Research Achievements

Expression of MUC21 gene and its glycosylated gene products was examined with breast carcinoma cells and tissue specimens with a variety of subtypes. It was found that MUC21 expression was associated with poor therapeutic outcomes among triple negative breast carcinoma patients but whether any association with the expression of particular glycoform of MUC21 is still unknown. An experimental system to investigate the contribution of interaction between MUC21 and galectin 3 in modulating apoptotic pathways was successfully established.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (56 results)

All 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (2 results) Journal Article (21 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 20 results,  Open Access: 12 results,  Acknowledgement Compliant: 11 results) Presentation (31 results) (of which Int'l Joint Research: 4 results,  Invited: 11 results) Book (2 results)

  • [Int'l Joint Research] Jagiellonian University(Poland)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] UT-MD Anderson Cancer Center(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Proteasome inhibitor loaded micelles enhance antitumor activity through macrophage reprograming by NF-κB inhibition"2017

    • Author(s)
      Hailiang Wu, Anqi Tao, John D. Martin, Sabina Quader, Xueying Liu, Kei Takahashi, Louise Hespel, Yutaka Miura, Yoshihiro Hayakawa, Tatsuro Irimura, Horacio Cabral, Kazunori Kataoka
    • Journal Title

      J. Pharm. Sci,

      Volume: - Issue: 9 Pages: 30217-30224

    • DOI

      10.1016/j.xphs.2017.03.031

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Heparanase augments inflammatory chemokine production from colorectal carcinoma cell lines.2016

    • Author(s)
      Tsunekawa N, Higashi N, Kogane Y, Waki M, Shida H, Nishimura Y, Adachi H, Nakajima M, Irimura T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 469 Issue: 4 Pages: 878-883

    • DOI

      10.1016/j.bbrc.2015.12.074

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Report on the use of nonclinical studies in the regulatory evaluation of oncology drugs2016

    • Author(s)
      Hayakawa Y, Kawada M, Nishikawa H, Ochiya T, Saya H, Seimiya H, Yao Y, Hayashi M, Kai C, Matsuda A, Naoe T, Ohtsu A, Okazaki T, Saji H, Sata M, Sugimura H, Sugiyama Y, Toi M, Irimura T
    • Journal Title

      Cancer Sci

      Volume: 107(2) Issue: 2 Pages: 189-202

    • DOI

      10.1111/cas.12857

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] An iminosugar-based heparanase inhibitor heparastatin (SF4) suppresses infiltration of neutrophils and monocytes into inflamed dorsal air pouches.2016

    • Author(s)
      Sue M, Higashi N, Shida H, Kogane Y, Nishimura Y, Adachi H, Kolaczkowska E, Kepka M, Nakajima M, Irimura T.
    • Journal Title

      Int Immunopharmacol

      Volume: 35 Pages: 15-21

    • DOI

      10.1016/j.intimp.2016.03.017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression.2016

    • Author(s)
      Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y.
    • Journal Title

      Cancer Sci.

      Volume: 107 Issue: 9 Pages: 1206-14

    • DOI

      10.1111/cas.13005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An iminosugar-based heparanase inhibitor heparastatin (SF4) suppresses infiltration of neutrophils and monocytes into inflamed dorsal air pouches2016

    • Author(s)
      Sue M, Higashi N, Shida H, Kogane Y, Nishimura Y, Adachi H, Kolaczkowskad , Kepka EMA, Nakajima M, Irimura T.
    • Journal Title

      Int Immunopharmacol

      Volume: 35 Pages: 5-21

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Heparanase auguments inflammatory chemokine production from colorectal carcinoma cell lines2016

    • Author(s)
      Tsunekawa N, Higashi N, Kogane Y, Waki M, Shida H, Nishimura Y, Adachi H, Nakajima M, Irimura T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 469(4) Pages: 878-883

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation.2015

    • Author(s)
      Takahashi K, Nagai N, Ogura K, Tsuneyama K, Saiki I, Irimura T, Hayakawa Y.
    • Journal Title

      Cancer Sci.

      Volume: 106 Issue: 7 Pages: 867-874

    • DOI

      10.1111/cas.12685

    • NAID

      120006389612

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lectin microarray-based sero-biomarker verification targeting aberrant O-linked glycosylation on mucin 12015

    • Author(s)
      Matsuda A, Kuno A, Nakagawa T, Ikehara Y, Irimura T, Yamamoto M, Nakanuma Y, Miyoshi E, Nakamori S, Nakanishi H, Viwatthanasittiphong C, Srivatanakul P, Miwa M, Shoda J, Narimatsu H
    • Journal Title

      Anal Chem

      Volume: 87(14) Pages: 7274-7281

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] POMGNT1 Is Glycosylated by Mucin-Type <i>O</i>-Glycans2015

    • Author(s)
      Xin X, Akasaka-Manya K, Manya H, Furukawa J, Kuwahara N, Okada K, Tsumoto H, Higashi N, Kato R, Shinohara Y, Irimura T, Endo T.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 38 Issue: 9 Pages: 1389-1394

    • DOI

      10.1248/bpb.b15-00415

    • NAID

      130005096979

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 免疫系とバイオマテリアル:総論2015

    • Author(s)
      入村達郎、伝田香里
    • Journal Title

      Biomaterials

      Volume: 33(2) Pages: 8-15

    • Related Report
      2015 Annual Research Report
    • Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation.2015

    • Author(s)
      Takahashi K, Nagai N, Ogura K, Tsuneyama K, Saiki I, Irimura T, Hayakawa Y.
    • Journal Title

      Cancer Sci

      Volume: 15

    • NAID

      120006389612

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The macrophage galactose-type lectin can function as an attachment and entry receptor for influenza virus.2014

    • Author(s)
      Ng WC, Liong S, Tate MD, Irimura T, Denda-Nagai K, Brooks AG, Londrigan SL, Reading PC.
    • Journal Title

      Jornal of Virology

      Volume: 88(3) Issue: 3 Pages: 1659-72

    • DOI

      10.1128/jvi.02014-13

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heparanase-mediated cleavage of macromolecular heparin accelerates release of granular components of mast cells from extracellular matrices.2014

    • Author(s)
      Higashi N, Waki M, Sue M, Kogane Y, Shida H, Tsunekawa N, Hasan A, Sato T, Kitahara A, Kasaoka T, Hayakawa Y, Nakajima M, Irimura T.
    • Journal Title

      Biochemical Jornal

      Volume: 458(2) Issue: 2 Pages: 291-9

    • DOI

      10.1042/bj20131463

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of neogenin-1 increases cell proliferation and motility in gastric cancer.2014

    • Author(s)
      Kim SJ, Wang YG, Lee HW, Kang HG, La SH, Choi IJ, Irimura T, Ro JY, Bresalier RS, Chun KH.
    • Journal Title

      Oncotarget

      Volume: 5(10) Pages: 3386-2298

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interaction of Muc4 and ErbB2 in a transgenic mouse model of gallbladder carcinoma: potential pathobiological implications.2014

    • Author(s)
      Miyahara N, Shoda J, Kawamoto T, Ishida H, Ueda T, Akimoto Y, Kawakami H, Irimura T.
    • Journal Title

      Oncol Rep

      Volume: 32(5) Issue: 5 Pages: 1796-1802

    • DOI

      10.3892/or.2014.3443

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Hirsutine as an anti-metastatic phytochemical by targeting NF-kB activation2014

    • Author(s)
      Chenghua Lou, Kei Takahashi, Tatsuro Irimura, Ikuo Saiki and Yoshihiro Hayakawa
    • Journal Title

      International Journal of Oncology

      Volume: 45 Issue: 5 Pages: 2085-2091

    • DOI

      10.3892/ijo.2014.2624

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages.2014

    • Author(s)
      Kee JY, Ito A, Hojo S, Hashimoto I, Igarashi Y, Tsuneyama K, Tsukada K, Irimura T, Shibahara N, Takasaki I, Inujima A, Nakayama T, Yoshie O, Sakurai H, Saiki I, Koizumi K.
    • Journal Title

      BMC Cancer.

      Volume: 14 Issue: 1 Pages: 949-949

    • DOI

      10.1186/1471-2407-14-949

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A unique dermal dendritic cell subset that skews the immune response toward Th2.2013

    • Author(s)
      Murakami R, Denda-Nagai K, Hashimoto S, Nagai S, Hattori M, Irimura T.
    • Journal Title

      Plos One

      Volume: 8(9) Pages: 73270-73270

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway.2013

    • Author(s)
      Goudarzi H, Iizasa H, Furuhashi M, Nakazawa S, Nakane R, Liang S, Hida Y, Yanagihara K, Kubo T, Nakagawa K, Kobayashi M, Irimura T, Hamada J.
    • Journal Title

      Cancer Letters

      Volume: 339(1) Pages: 82-92

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional roles of tumor necrosis factor-related apoptosis-inducing ligand-DR5 interaction in B16F10 cells by activating the nuclear factor-KB pathway to induce metastatic potential2013

    • Author(s)
      Kei Takahashi, Kazuyoshi Takeda, Ikuo Saiki, Tatsuro Irimura and Yoshihiro Hayakawa
    • Journal Title

      Cancer Science

      Volume: 104 Issue: 5 Pages: 558-562

    • DOI

      10.1111/cas.12112

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] ムチン21とその糖鎖: がんによる免疫抑制とアポトーシスの制御に関わるムチン2017

    • Author(s)
      入村達郎
    • Organizer
      糖鎖免疫シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2017-01-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Future of Glycobiologics2016

    • Author(s)
      Tatsuro Irimura
    • Organizer
      Frontier 2016-UT/EPFL Joint Symposium
    • Place of Presentation
      Lausanne
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] MUC1 with truncated O-glycans induces humoral immune responses and suppresses the carcinoma growth and metastasis2015

    • Author(s)
      Kaori Denda-Nagai, Tatsuro Irimura
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] C-Type Lectins on Dendritic Cell and Macrophages Regulate Infection and Immunity2015

    • Author(s)
      Irimura Tatsuro
    • Organizer
      LMU-UT Symposium
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2015-10-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] エボラウィルス-MGL相互作用の謎2015

    • Author(s)
      藤平陽彦、宇佐美克明、伝田香里、古川潤一、篠原康郎、松野啓太、高田礼人、河岡義裕、入村達郎
    • Organizer
      糖鎖免疫シンポジウム
    • Place of Presentation
      東京医科歯科大学(東京)
    • Year and Date
      2015-08-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] がん悪性化進展を促す炎症性免疫応答の維持機構におけるIL-17の重要性2015

    • Author(s)
      早川芳弘、永井直、斉木育夫、入村達郎
    • Organizer
      第24回日本がん転移学会
    • Place of Presentation
      シティプラザ大阪(大阪)
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] MGL(CD301)in infection and immunity2015

    • Author(s)
      Irimura Tatsuro
    • Organizer
      International Workshop on Mucins in Health and diseases
    • Place of Presentation
      Cambridge, UK
    • Year and Date
      2015-07-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 薬科学に未来はあるか2015

    • Author(s)
      入村達郎
    • Organizer
      日本薬剤会第30回記念大会
    • Place of Presentation
      長崎ブリックホール(長崎)
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 糖鎖付加MUC1に対する免疫応答による癌の増殖と転移の制御2015

    • Author(s)
      難波愛理、伝田香里、野地美樹、入村達郎
    • Organizer
      第135日本薬学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Heparanase-mediated cleavage of macromolecular heparin accelerates release of granular components of mouse peritoneal cell-derived mast cells.2014

    • Author(s)
      東伸昭,入村達郎
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] マクロファージガラクトース型C型レクチン(MGL/CD301)による炎症と免疫の制御2014

    • Author(s)
      伝田香里、入村達郎
    • Organizer
      第12回糖鎖科学コンソーシアムシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Identification of Hirsutine as an anti-metastatic phytochemical by targeting NF-κB activation.2014

    • Author(s)
      Lou C, Takahashi K, Irimura T, Saiki I, Hayakawa Y.
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] A unique dermal dendritic cell subset that skews the immune response toward Th2.2014

    • Author(s)
      Irimura T.
    • Organizer
      MGH and U-Tokyo Joint Symposium on Frontiers in Biomedical Engineering
    • Place of Presentation
      Cambridge, MA, USA
    • Year and Date
      2014-09-24 – 2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Public private partnership in Japanese pharmaceutical affairs.2014

    • Author(s)
      Irimura T.
    • Organizer
      FIP Congress
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2014-08-31 – 2014-09-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] マスト細胞顆粒内ヘパリンの切断は細胞外マトリックスからの生理活性物質の放出を促進する2014

    • Author(s)
      東伸昭,中島元夫、入村達郎
    • Organizer
      第33回日本糖質学会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-08-10 – 2014-08-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Vd1T細胞を起点とする自然炎症はがん悪性化を促進する2014

    • Author(s)
      早川芳弘、済木育夫、入村達郎
    • Organizer
      第23回がん転移学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Requirement of CD4T cells for establishing inflammatory tumor microenvironment in 4T1breast cancer model.2014

    • Author(s)
      Takahashi K, Nagai N, Saiki I, Irimura T, Hayakawa Y.
    • Organizer
      The 22nd International Symposium on Molecular Cell Biology of Macrophages.
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2014-06-02 – 2014-06-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Differential glycosylation of MUC1 has an impact on cancer immunity through the function of MGL1/MGL22013

    • Author(s)
      木村翔彦、伝田-永井 香里、入村達郎
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] がん悪性化進展を促進するgdT17 細胞を起点とした炎症性微小環境は宿主―がん細胞相互作用により増強される2013

    • Author(s)
      木村好孝、松下(佐藤)まりも、善本隆之、田原秀晃、済木育夫、入村達郎、早川芳弘
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] がん悪性化進展モデルにおける炎症性微小環境のがん悪性化形質獲得に与える影響2013

    • Author(s)
      永井直、済木育夫、入村達郎、早川芳弘
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 4T1乳がんモデルでの炎症性腫瘍微小環境形成におけるCD4陽性T細胞の重要性2013

    • Author(s)
      高橋恵生、永井直、常山幸一、済木育夫、入村達郎、早川芳弘
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生物発光イメージングによるマウス4T1細胞の腫瘍微小環境における転写因子NFkBを介した炎症性シグナル活性化の時空間的解析

    • Author(s)
      髙橋恵生、永井直、済木育夫、入村達郎、早川芳弘
    • Organizer
      第17回がん分子標的治療学会学術集会
    • Place of Presentation
      国立京都国際会館・京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス4T1乳がんモデルでの炎症性腫瘍微小環境形成におけるCD4陽性T細胞の重性

    • Author(s)
      高橋恵生、永井直、済木育夫、入村達郎、早川芳弘
    • Organizer
      第22回日本がん転移学会学術集会
    • Place of Presentation
      ホテルブエナビスタ松本・松本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 結腸がんの転移微小環境におけるヘパラナーゼ:ケモカイン産生誘導における役割

    • Author(s)
      恒川直輝、東伸昭、中島元夫、入村達郎
    • Organizer
      第22回日本がん転移学会学術集会
    • Place of Presentation
      ホテルブエナビスタ松本・松本
    • Related Report
      2013 Annual Research Report
  • [Presentation] がん悪性化進展モデルにおける炎症性美装環境のがん悪性化形質獲得に与える影響

    • Author(s)
      永井直、入村達郎、早川芳弘
    • Organizer
      第22回日本がん転移学会学術集会
    • Place of Presentation
      ホテルブエナビスタ松本・松本
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヘパラナーゼは結腸がん細胞株に作用し転移関連分子の発現を誘導する

    • Author(s)
      恒川直輝、東伸昭、中島元夫、入村達郎
    • Organizer
      第32回日本糖質学会年会
    • Place of Presentation
      大阪国際交流センター・大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 結腸がんの転移微小環境におけるヘパラナーゼの関与

    • Author(s)
      恒川直輝、東伸昭、中島元夫、入村達郎
    • Organizer
      第18回日本病態プロテアーゼ学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター・大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] "MUC21 regulates apoptosis in a glycosylation dependent manner"

    • Author(s)
      Yuan Tian, Kaori Denda-Nagai, Toshihisa Ogawa, Tatsuro Irimura
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜・横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cancer immune escalation process triggered by activation of gamma-delta T17 cells through MyD88/IL-23 cascade.

    • Author(s)
      Yoshitaka Kimura, Marimo Sato-Matsushita, Takayuki Yoshimoto, Hideaki Tahara, Ikuo Saiki, Tatsuro Irimura, Yoshihiro Hayakawa.
    • Organizer
      日本免疫学会学術集会2013
    • Place of Presentation
      幕張メッセ、千葉
    • Related Report
      2013 Annual Research Report
  • [Presentation] Heparanase in metastatic microenvironment of colon cancer: a potential inducer of chemokine production

    • Author(s)
      Naoki Tsunekawa, Nobuaki Higashi, Tatsuro Irimura.
    • Organizer
      日本免疫学会学術集会2013
    • Place of Presentation
      幕張メッセ、千葉
    • Related Report
      2013 Annual Research Report
  • [Presentation] Heparanase in metastatic microenvironment of colon cancer: a potential inducer of chemokine production.

    • Author(s)
      Naoki Tsunekawa, Nobuaki Higashi, Tatsuro Irimura.
    • Organizer
      日本免疫学会学術集会2013
    • Place of Presentation
      幕張メッセ、千葉
    • Related Report
      2013 Annual Research Report
  • [Book] C-Type Lectin Receptors in Immunity2016

    • Author(s)
      Kaori Denda-Nagai and Tatsuro Irimura
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] 基礎生命科学2014

    • Author(s)
      入村達郎
    • Total Pages
      190
    • Publisher
      培風館
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2022-02-16  

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