MUC21 glycoforms as the target of cancer diagnosis and therapy
| Project/Area Number | 25293011 |
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Juntendo University (2016)
St. Luke's International University (2014-2015)
The University of Tokyo (2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
伝田 香里 順天堂大学, 医学部, 助教 (00313122)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed(Fiscal Year 2016)
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| Budget Amount *help |
¥18,980,000 (Direct Cost : ¥14,600,000、Indirect Cost : ¥4,380,000)
Fiscal Year 2015 : ¥5,980,000 (Direct Cost : ¥4,600,000、Indirect Cost : ¥1,380,000)
Fiscal Year 2014 : ¥5,980,000 (Direct Cost : ¥4,600,000、Indirect Cost : ¥1,380,000)
Fiscal Year 2013 : ¥7,020,000 (Direct Cost : ¥5,400,000、Indirect Cost : ¥1,620,000)
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| Keywords | ムチン / 乳腺がん / 治療抵抗性 / モノクローナル抗体 / グライコフォーム / MUC21 / 腫瘍マーカー / 乳がん / 糖鎖 / がん / アポトーシス / 抗がん剤 |
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| Outline of Final Research Achievements |
Expression of MUC21 gene and its glycosylated gene products was examined with breast carcinoma cells and tissue specimens with a variety of subtypes. It was found that MUC21 expression was associated with poor therapeutic outcomes among triple negative breast carcinoma patients but whether any association with the expression of particular glycoform of MUC21 is still unknown. An experimental system to investigate the contribution of interaction between MUC21 and galectin 3 in modulating apoptotic pathways was successfully established.
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Report
(5results)
Research Products
(55results)
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[Journal Article] Proteasome inhibitor loaded micelles enhance antitumor activity through macrophage reprograming by NF-κB inhibition"2017
Author(s)
Hailiang Wu, Anqi Tao, John D. Martin, Sabina Quader, Xueying Liu, Kei Takahashi, Louise Hespel, Yutaka Miura, Yoshihiro Hayakawa, Tatsuro Irimura, Horacio Cabral, Kazunori Kataoka
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Journal Title
J. Pharm. Sci,
Volume : -
Pages : 30217-30224
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression.2016
Author(s)
Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y.
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Journal Title
Cancer Sci.
Volume : 107
Pages : 1206-14
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Lectin microarray-based sero-biomarker verification targeting aberrant O-linked glycosylation on mucin 12015
Author(s)
Matsuda A, Kuno A, Nakagawa T, Ikehara Y, Irimura T, Yamamoto M, Nakanuma Y, Miyoshi E, Nakamori S, Nakanishi H, Viwatthanasittiphong C, Srivatanakul P, Miwa M, Shoda J, Narimatsu H
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Journal Title
Anal Chem
Volume : 87(14)
Pages : 7274-7281
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] POMGNT1 Is Glycosylated by Mucin-Type O-Glycans.2015
Author(s)
Xin X, Akasaka-Manya K, Manya H, Furukawa J, Kuwahara N, Okada K, Tsumoto H, Higashi N, Kato R, Shinohara Y, Irimura T, Endo T.
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Journal Title
Biol Pharm Bull
Volume : 38
Pages : 1389-1394
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages.2015
Author(s)
Kee JY, Ito A, Hojo S, Hashimoto I, Igarashi Y, Tsuneyama K, Tsukada K, Irimura T, Shibahara N, Takasaki I, Inujima A, Nakayama T, Yoshie O, Sakurai H, Saiki I, Koizumi K.
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Journal Title
BMC Cancer.
Volume : in press
Pages : 949-949
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Heparanase-mediated cleavage of macromolecular heparin accelerates release of granular components of mast cells from extracellular matrices.2014
Author(s)
Higashi N, Waki M, Sue M, Kogane Y, Shida H, Tsunekawa N, Hasan A, Sato T, Kitahara A, Kasaoka T, Hayakawa Y, Nakajima M, Irimura T.
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Journal Title
Biochemical Jornal
Volume : 458(2)
Pages : 291-9
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 薬科学に未来はあるか2015
Author(s)
入村達郎
Organizer
日本薬剤会第30回記念大会
Place of Presentation
長崎ブリックホール（長崎）
Year and Date
2015-05-23
Related Report
Invited
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