Elucidation of mechanisms involved in the immunosuppressive effects of adipose derived stem cells and the improvement of their properties
Project/Area Number |
25461216
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Nagoya University |
Principal Investigator |
Maruyama Shoichi 名古屋大学, 医学(系)研究科(研究院), 准教授 (10362253)
|
Co-Investigator(Kenkyū-buntansha) |
AKIYAMA Shin'ichi 名古屋大学, 大学院医学系研究科, 特任講師 (20500010)
TSUBOI Naotake 名古屋大学, 医学部附属病院, 講師 (50566958)
MATSUO Seiichi 名古屋大学, 大学院医学系研究科, 教授 (70190410)
KATO Noritoshi 名古屋大学, 医学部附属病院, 病院助教 (90716052)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 脂肪 / 間葉系幹細胞 / 間葉系間質細胞 / オートファジー / 微小環境因子 / M2マクロファージ / HGF / 組織因子 / 低血清 / mTOR |
Outline of Final Research Achievements |
In order to clarify the difference between the cell characteristic of low serum cultured adipose derived stem cells (LASC), which are our original, and those of high serum cultured adipose derived stem cells (HASC), we analyzed the autophagy system, metabolic pathway, glycolytic pathway, the metabolites in the cells, and cytokine secretion. Autophagy was enhanced in LASC as compared to HASC, although mechanisms remain to be clarified. Autophagy was not aggravated by the rapamycin treatment. No significant difference was observed in glycolytic pathway either. Concerning the cytokine secretion, MIP-1 alpha increased and fractalkine/CX3CL1 decreased in LASC.
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Report
(4 results)
Research Products
(127 results)
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[Journal Article] Patient age and the prognosis of idiopathic membranous nephropathy.2014
Author(s)
Yamaguchi M, Ando M, Yamamoto R, Akiyama S, Kato S, Katsuno T, Kosugi T, Sato W, Tsuboi N, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S.
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Journal Title
PLoS One
Volume: 9(10)
Issue: 10
Pages: 110376-110376
DOI
Related Report
Peer Reviewed
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[Journal Article] Midkine Regulates BP through Cytochrome P450-Derived Eicosanoids.2014
Author(s)
Sato Y, Sato W, Maruyama S, Wilcox CS, Falck JR, Masuda T, Kosugi T, Kojima H, Maeda K, Furuhashi K, Ando M, Imai E, Matsuo S, Kadomatsu K.
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Journal Title
J Am Soc Nephrol
Volume: Epub
Related Report
Peer Reviewed
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[Journal Article] Outcomes of primary nephrotic syndrome in elderly Japanese: retrospective analysis of the Japan Renal Biopsy Registry (J-RBR).2014
Author(s)
Yokoyama H, Sugiyama H, Narita I, Saito T, Yamagata K, Nishio S, Fujimoto S, Mori N, Yuzawa Y, Okuda S, Maruyama S, Sato H, Ueda Y, Makino H, Matsuo S.
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Journal Title
Clin Exp Nephrol
Volume: Epub
Related Report
Peer Reviewed
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[Journal Article] Smoking is a risk factor for the progression of idiopathic membranous nephropathy.2014
Author(s)
Yamaguchi M, Ando M, Yamamoto R, Akiyama S, Kato S, Katsuno T, Kosugi T, Sato W, Tsuboi N, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins.2014
Author(s)
Miyashita H, Chikazawa M, Otaki N, Hioki Y, Shimozu Y, Nakashima F, Shibata T, Hagihara Y, Maruyama S, Matsumi N, Uchida K.
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Journal Title
Sci Rep.
Volume: 4
Issue: 1
Pages: 5343-5343
DOI
Related Report
Peer Reviewed
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[Journal Article] A multicenter cross-sectional study of circulating soluble urokinase receptor in Japanese patients with glomerular disease2014
Author(s)
Wada T, Nangaku M, Maruyama S, Imai E, Shoji K, Kato S, Endo T, Muso E, Kamata K, Yokoyama H, Fujimoto K, Obata Y, Nishino T, Kato H, Uchida S, Sasatomi Y, Saito T, Matsuo S.
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Journal Title
Kidney Int
Volume: 85
Issue: 3
Pages: 641-8
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Significance of combined cyclosporine-prednisolone therapy and cyclosporine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome: a randomized controlled multicenter trial.2014
Author(s)
Saito T, Iwano M, Matsumoto K, Mitarai T, Yokoyama H, Yorioka N, Nishi S, Yoshimura A, Sato H, Ogahara S, Shuto H, Kataoka Y, Ueda S, Koyama A, Maruyama S, Nangaku M, Imai E, Matsuo S, Tomino
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Journal Title
Clin Exp Nephrol
Volume: 18(5)
Issue: 5
Pages: 784-94
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Long-Term Effects of Spironolactone in Peritoneal Dialysis Patients.2014
Author(s)
Ito Y, Mizuno M, Suzuki Y, Tamai H, Hiramatsu T, Ohashi H, Ito I, Kasuga H, Horie M, Maruyama S, Yuzawa Y, Matsubara T, Matsuo S; on behalf of the Nagoya Spiro Study Group.
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Journal Title
Am Soc Nephrol.
Volume: 25(5)
Issue: 5
Pages: 1094-102
DOI
Related Report
Peer Reviewed
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[Journal Article] CD147/basigin reflects renal dysfunction in patients with acute kidney injury.2014
Author(s)
Nagaya H, Kosugi T, Maeda-Hori M, Maeda K, Sato Y, Kojima H, Hayashi H, Kato N, Ishimoto T, Sato W, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S.
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Journal Title
Clin Exp Nephrol.
Volume: 18
Issue: 5
Pages: 746-54
DOI
Related Report
Peer Reviewed
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[Journal Article] Geriatric nutritional risk index accurately predicts cardiovascular mortality in incident hemodialysis patients.2013
Author(s)
Takahashi H, Ito Y, Ishii H, Aoyama T, Kamoi D, Kasuga H, Yasuda K, Maruyama S, Matsuo S, Murohara T, Yuzawa Y.
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Journal Title
J Cardiol.
Volume: S0914-5087(13)
Issue: 1
Pages: 352-3
DOI
Related Report
Peer Reviewed
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[Journal Article] Rat adipose tissue-derived stem cells attenuate peritoneal injuries in rat zymosan-induced peritonitis accompanied by complement activation.2013
Author(s)
Kim H, Mizuno M, Furuhashi K, Katsuno T, Ozaki T, Yasuda K, Tsuboi N, Sato W, Suzuki Y, Matsuo S, Ito Y ,Maruyama S1.
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Journal Title
Cytotherapy.
Volume: 16(3)
Issue: 3
Pages: 357-68
DOI
Related Report
Peer Reviewed
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[Journal Article] Deficiency of growth factor midkine exacerbates necrotizing glomerular injuries in progressive glomerulonephritis2013
Author(s)
Kojima H, Kosugi T, Sato W, Sato Y, Maeda K, Kato N, Kato K, Inaba S, Ishimoto T, Tsuboi N, Matsuo S, Maruyama S, Yuzawa Y, Kadomatsu K
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Journal Title
Am J Pathol
Volume: 182(2)
Issue: 2
Pages: 410-419
DOI
Related Report
Peer Reviewed
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[Journal Article] Association of cardiac valvular calcifications and C-reactive protein with cardiovascular mortality in incident hemodialysis patients: a Japanese cohort study.2013
Author(s)
Takahashi H, Ishii H, Aoyama T, Kamoi D, Kasuga H, Ito Y, Yasuda K, Tanaka M, Yoshikawa D, Maruyama S, Matsuo S, Murohara T, Yuzawa Y.
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Journal Title
Am J Kidney Dis
Volume: 61(2)
Issue: 2
Pages: 254-61
DOI
Related Report
Peer Reviewed
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[Journal Article] Multi-specificity of IgM antibodies raised against advanced glycation end products: Involvement of electronegative potential of antigens2013
Author(s)
Chikazawa, M., Otaki, N., Shibata, T., Miyashita, H., Kawai, Y., Maruyama, S., Toyokuni, S., Kitaura, Y., Tsukasa Matsuda, and Uchida, K.
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Journal Title
J. Biol. Chem
Volume: 288
Issue: 19
Pages: 13204-13214
DOI
Related Report
Peer Reviewed
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[Journal Article] Serum-Starved Adipose-Derived Stromal Cells Ameliorate Crescentic GN by Promoting Immunoregulatory Macrophages.2013
Author(s)
Furuhashi K, Tsuboi N, Shimizu A, Katsuno T, Kim H, Saka Y, Ozaki T, Sado Y, Imai E, Matsuo S, Maruyama S.
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Journal Title
J Am Soc Nephrol.
Volume: 24(4)
Issue: 4
Pages: 587-603
DOI
Related Report
Peer Reviewed
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[Journal Article] Anti-C5a complementary peptide ameliorates acute peritoneal injuries induced by neutralization of Crry and CD59.2013
Author(s)
Mizuno T, Mizuno M, Imai M, Suzuki Y, Kushida M, Noda Y, Maruyama S, Okada H, Okada N, Matsuo S, Ito Y.
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Journal Title
Am J Physiol Renal Physiol.
Volume: 305(11)
Issue: 11
Pages: 1603-1616
DOI
Related Report
Peer Reviewed
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[Journal Article] TGF-β1 Promotes Lymphangiogenesis during Peritoneal Fibrosis.2013
Author(s)
Kinashi H, Ito Y, Mizuno M, Suzuki Y, Terabayashi T, Nagura F, Hattori R, Matsukawa Y, Mizuno T, Noda Y, Nishimura H, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y.
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Journal Title
J Am Soc Nephrol.
Volume: 24
Issue: 10
Pages: 1627-1642
DOI
Related Report
Peer Reviewed
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[Journal Article] Significance of combined cyclosporine-prednisolone therapy and cyclosporine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome: a randomized controlled multicenter trial.2013
Author(s)
Saito T, Iwano M, Matsumoto K, Mitarai T, Yokoyama H, Yorioka N, Nishi S, Yoshimura A, Sato H, Ogahara S, Shuto H, Kataoka Y, Ueda S, Koyama A, Maruyama S, Nangaku M, Imai E, Matsuo S, Tomino Y; The Refractory Nephrotic Syndrome Study Group.
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Journal Title
Clin Exp Nephrol
Volume: Epub
Related Report
Peer Reviewed
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[Journal Article] CD147/basigin reflects renal dysfunction in patients with acute kidney injury.2013
Author(s)
Nagaya H, Kosugi T, Maeda-Hori M, Maeda K, Sato Y, Kojima H, Hayashi H, Kato N, Ishimoto T, Sato W, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S.
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Journal Title
Clin Exp Nephrol.
Volume: Epub
Related Report
Peer Reviewed
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[Journal Article] Long-Term Effects of Spironolactone in Peritoneal Dialysis Patients.2013
Author(s)
Ito Y, Mizuno M, Suzuki Y, Tamai H, Hiramatsu T, Ohashi H, Ito I, Kasuga H, Horie M, Maruyama S, Yuzawa Y, Matsubara T, Matsuo S; on behalf of the Nagoya Spiro Study Group.
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Journal Title
J Am Soc Nephrol
Volume: Epub
Related Report
Peer Reviewed
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[Presentation] MICROARRAY ANALYSIS OF GENE EXPRESSION IN LOW SERUM CULTURED ADIPOSE DERIVED STROMAL CELL.2015
Author(s)
Kamimura, Yutaka, Akiyama, Shin’i’chi, Tsuboi, Naotake, Kim, Hangsoo, Katsuno, Takayuki, Horinouchi, Asuka, Maruyama, Shoichi
Organizer
The ISSCR 2015
Place of Presentation
Stockholm,Sweden
Year and Date
2015-06-26
Related Report
Int'l Joint Research
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[Presentation] Vascular Endothelial Growth Factor Receptor-3 Can Be a New Target to Improve Ultrafiltration Dysfunction in Methylglyoxal-Induced Peritoneal Injury2014
Author(s)
Takeshi Terabayashi, MD, Yasuhiko Ito, MD, PhD, Masashi Mizuno, MD, PhD, Yasuhiro Suzuki, MD, Hiroshi Kinashi, MD, Fumiko Sakata, Shoichi Maruyama, MD, Yoshifumi Takei, PhD, Seiichi Matsuo, MD.
Organizer
Kidney Week 2014
Place of Presentation
フィラデルフィア (米国)
Year and Date
2014-11-11 – 2014-11-16
Related Report
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[Presentation] High Ferritin Level and Low Nutrition Status Predicts Higher Risk of Infection-Related Hospitalization in Incident Dialysis Patients: A Japanese Prospective Cohort Study2014
Author(s)
Sawako Kato, MD, PhD, Shoichi Maruyama, MD, Bengt Lindholm, MD, PhD, Yukio Yuzawa, MD, Yoshinari Tsuruta, MD, Seiichi Matsuo, MD.
Organizer
Kidney Week 2014
Place of Presentation
フィラデルフィア (米国)
Year and Date
2014-11-11 – 2014-11-16
Related Report
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[Presentation] Aortic Calcification Was Accelerated After Radical Nephrectomy: Clinical Impact of GFR Decline for Vascular Calcification2014
Author(s)
Yoshinari Yasuda, MD, PhD, Akitaka Suzuki, MD, Ryohei Hattori, MD, Yasuhito Funahashi, MD, PhD, Shoichi Maruyama, MD, Seiichi Matsuo, MD. CKD
Organizer
Kidney Week 2014
Place of Presentation
フィラデルフィア (米国)
Year and Date
2014-11-11 – 2014-11-16
Related Report
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[Presentation] The Growth Factor Midkine Reflect the Disease Activity in Lupus Nephritis2014
Author(s)
Tomohiro Masuda, MD, Kayaho Maeda, MD, Waichi Sato, MD, PhD, Tomoki Kosugi, MD, PhD, Yuka Sato, MD, Takuji Ishimoto, MD, PhD, Seiichi Matsuo, MD, Shoichi Maruyama, MD.
Organizer
Kidney Week 2014
Place of Presentation
フィラデルフィア (米国)
Year and Date
2014-11-11 – 2014-11-16
Related Report
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[Presentation] Home Blood Pressure Telemonitoring System Among Patients with CKD: An Attempt to Achieve Optimal Blood Pressure Control with Real-Time Remote.2014
Author(s)
Yoshinari Yasuda, MD, PhD, Misao Niwa, Kanako Shibata, Mayumi Kamiya, Imai Junko, Sawako Kato, MD, PhD, Shoichi Maruyama, MD, Seiichi Matsuo, MD.
Organizer
Kidney Week 2014
Place of Presentation
フィラデルフィア (米国)
Year and Date
2014-11-11 – 2014-11-16
Related Report
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[Presentation] 腎臓分野の新しいシーズの探索2014
Author(s)
松尾 清一、丸山 彰一
Organizer
第57回日本腎臓学会学術総会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2014-07-04 – 2014-07-06
Related Report
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[Presentation] 膜性腎症とPLA2R2014
Author(s)
丸山 彰一、秋山 真一、松尾 清一
Organizer
第57回日本腎臓学会学術総
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2014-07-04 – 2014-07-06
Related Report
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[Presentation] Spironolactone improving intrarenal renin-angiotensin system activation in type 2diabetic nephropathy patients with overt albuminuria.2014
Author(s)
Sawako Kato, Shoichi Maruyama, Hirofumi Makino, Jun Wada, Takashi Uzu, Hisazumi Araki, Daisuke Koya,Keizo Kanasaki, Akira Nishiyama, Hiroyuki Kobori,Enyu Imai,Masahiko Ando, Yutaka Oiso, Seiichi Matsuo
Organizer
The 14th Asian Pacific Congress of Nephrology
Place of Presentation
品川プリンスホテル(東京都港区)
Year and Date
2014-05-14 – 2014-05-17
Related Report
-
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[Presentation] Spironolactone improving intrarenal renin-angiotensin system activation in type 2diabetic nephropathy patients with overt albuminuria.2014
Author(s)
Sawako Kato, Shoichi Maruyama, Hirofumi Makino, Jun Wada, Takashi Uzu, Hisazumi Araki, Daisuke Koya, Keizo Kanasaki, Akira Nishiyama, Hiroyuki Kobori, Enyu Imai, Masahiko Ando, Yutaka Oiso, Seiichi Matsuo
Organizer
The 14th Asian Pacific Congress of Nephrology
Place of Presentation
SHINAGAWA PRINCE HOTEL(東京都港区)
Related Report
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[Presentation] BENEFICIAL EFFECT OF CONTINUOUS ERYTHROPOIETIN RECEPTOR ACTIVATOR (C.E.R.A.) IN CAPD PATIENTS.2013
Author(s)
Yasuhiro Suzuki,Yasuhiko Ito, Masashi Mizuno, Hideki Hiramatsu, Hiroshi Kinashi, Humiko Nagura, Takeshi Terabayashi, Yumi Sei, Takako Tomita, Shoichi Maruyama, Seiichi Matsuo.
Organizer
The World Congress of Nephrology 2013
Place of Presentation
香港(中国)
Related Report
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[Presentation] LOW SERUM CULTURED ADIPOSE-DERIVED MESENCHIMAL STROMAL CELLS AMERIORATE RAT MODEL WITH UNILATERAL URETERAL OBSTRUCTION.2013
Author(s)
Tomoko Abe, Asuka Horinouchi, Hangsoo Kim, Kazuhiro Huruhashi, Shinichi Aiyama, Takayuki Katsuno, Kaoru Yasuda, Takinori Ozaki, Naotake Tsuboi, Seiichi Matsuo, Shouichi Maruyama.
Organizer
The World Congress of Nephrology 2013
Place of Presentation
香港(中国)
Related Report
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[Presentation] THE SERUM BETA 2-MICROGLOBULIN LEVEL PREDICTS PATIENT SURVIVAL IN ASSOCIATION WITH THE RESIDUAL RENAL FUNCTION IN JAPANESE PATIENTS ON PERITONEAL DIALYSIS: A PROSPECTIVE MULTICENTER COHORT STUDY (PDR-CS) .2013
Author(s)
Hitoshi Sugiyama, Yasuhiko Ito, Kazuhiko Tsuruya, Hisako Yoshida, Hiroki Maruyama, Shin Goto, Tomoya Nishino, Masaaki Nakayama, Hidetomo Nakamoto, Hiroshi Morinaga, Seiichi Matsuo, Hirofumi Makino.
Organizer
The World Congress of Nephrology 2013
Place of Presentation
香港(中国)
Related Report
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[Presentation] DESMOPRESSIN IS EFFECTIVE IN PREVENTING OVERCORRECTION OF HYPONATREMIA.2013
Author(s)
Takaya Ozeki, Hideaki Shimizu, Akihiro Ryuge, Yukako Ooyama, Takahiro Imaizumi, Rui Kawato, Takuya Hamada, Atsushi Nomura, Tatsuhito Tomino, Yoshiro Fujita, Shoichi Maruyama.
Organizer
The World Congress of Nephrology 2013
Place of Presentation
香港(中国)
Related Report
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[Presentation] Serum-starved adipose-derived stromal cells ameliorate rat crescentic glomerulonephritis by promoting immunoregulatory macrophages.2013
Author(s)
Kazuhiro Furuhashi, Naotake Tsuboi, Asuka Shimizu, Yiqin Shi, Hangsoo Kim, Takayuki Katsuno, Yosuke Saka, Takenori Ozaki, Waichi Sato, Enyu Imai, Seiichi Matsuo, Shoichi Maruyama
Organizer
ISSCR(International Society for Stem Cell Research) 11th Annual Meeting
Place of Presentation
Boston(USA)
Related Report
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[Presentation] Spironolactone Prevents Cardiac Hypertrophy in Peritoneal Dialysis Patients without Significant Adverse Effects.2013
Author(s)
Yasuhiko Ito, MD, PhD, Masashi Mizuno, MD, PhD, Yasuhiro Suzuki, MD, Hirotake Kasuga, MD, PhD, Shoichi Maruyama, MD, Yukio Yuzawa, MD, Seiichi Matsuo, MD
Organizer
Kidney Week 2013
Place of Presentation
Atlanta(USA)
Related Report
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[Presentation] Neutrophil/Lymphocyte Ratio as a Predictor of Cardiovascular Events in Japanese Patients Starting Renal Replacement Therapy.2013
Author(s)
Sawako Kato, MD, PhD, Bengt Lindholm, MD, PhD, Yukio Yuzawa, MD, Seiichi Matsuo, MD, Shoichi Maruyama, MD
Organizer
Kidney Week 2013
Place of Presentation
Atlanta(USA)
Related Report
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[Presentation] CD147 Ameliorates Lupus Nephritis through the Regulation of Helper T Cell 17 Differentiation.2013
Author(s)
Kayaho Maeda, MD, Tomoki Kosugi, MD, PhD, Waichi Sato, MD, PhD, Hiroshi Kojima, MD, Yuka Sato, MD, Mayuko Maeda, MD, Shoichi Maruyama, MD, Seiichi Matsuo, MD
Organizer
Kidney Week 2013
Place of Presentation
Atlanta(USA)
Related Report
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[Presentation] Mac-1 Deficiency Protects Mouse from Pulmonary Hemorrhage, whereas Exacerbates Glomerulonephritis in Experimental Model of Systemic Lupus Erythematosus.2013
Author(s)
Yiqin Shi, Naotake Tsuboi, MD, PhD, Kazuhiro Furuhashi, MD, PhD, Shoichi Maruyama, MD, Seiichi Matsuo, MD
Organizer
Kidney Week 2013
Place of Presentation
Atlanta(USA)
Related Report
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[Presentation] Glycosylated Protein CD147 Reflects Renal Dysfunction in Patients with Acute Tubular Necrosis.2013
Author(s)
Hiroshi Kojima, MD, Tomoki Kosugi, MD, PhD, Mayuko Maeda, MD, Kayaho Maeda, MD, Yuka Sato, MD, Hiroki Hayashi, MD, Waichi Sato, MD, PhD, Seiichi Matsuo, MD, Shoichi Maruyama, MD
Organizer
Kidney Week 2013
Place of Presentation
Atlanta(USA)
Related Report
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[Presentation] Resistance to Immunosuppressive Therapy in Patients with Primary Nephrotic Syndrome: Japan Nephrotic Syndrome Cohort Study (JNSCS)2013
Author(s)
Ryohei Yamamoto, MD, PhD, Shoichi Maruyama, MD, Hitoshi Yokoyama, MD, PhD, Seiichi Matsuo, MD, Enyu Imai, MD, PhD
Organizer
Kidney Week 2013
Place of Presentation
Atlanta(USA)
Related Report
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