Involvement of oxidative stress and check points in CKD-MBD

• Project/Area Number: 25461247
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: The University of Tokushima
• Principal Investigator: HAMADA Yasuhiro 徳島大学, 大学院医歯薬学研究部, 教授 (30397830)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 骨代謝 / 低回転骨 / 酸化ストレス / 糖尿病性骨減少症 / CKD-MBD

Outline of Final Research Achievements

Diabetes Mellitus is one of the representative diseases to cause chronic kidney disease - mineral and bone disorder (CKD-MBD). The bone disorder of diabetes shows low turnover bone. In order to elucidate the involvement of oxidative stress in low turnover bone, statin, which is a lipid-lowering medication and has anti-oxidative effct, were administered to diabetic animal model. In conclusion, administration of statin improved low turnover diabetic osteopenia.

Research Products

• [Journal Article] Effect of dietary components on renal inorganic phosphate (Pi) excretion induced by a Pi-depleted diet (2014)
  • Author(s): Ohnishi R, Segawa H, Ohmoto T, Sasaki S, Hanazaki A, Mori A, Ikuta K, Furutani J, Kawakami E, Tatsumi S, Hamada Y, Miyamoto K
  • Journal Title: J Med Invest Volume: 61 Pages: 162-170
  • NAID: 130004822704
  • Peer Reviewed
• [Journal Article] Diabetic osteopenia by decreased β-catenin signaling is partly induced by epigenetic derepression of sFRP-4 gene (2014)
  • Author(s): Mori K, Kitazawa R, Kondo T, Mori M, Hamada Y, Nishida M, Minami Y, Haraguchi R, Takahashi Y, Kitazawa S.
  • Journal Title: PLoS One Volume: 9 Issue: 7 Pages: e102797-e102797
  • DOI: 10.1371/journal.pone.0102797
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of dietary components on renal inorganic phosphate (Pi) excretion induced by a Pi-depleted diet. (2014)
  • Author(s): Ritsuko Ohnishi, Hiroko Segawa, Tomoyo Ohmoto, Shohei Sasaki, Ai Hanazaki, Ayaka Mori, Kayo Ikuta, Junya Furutani, Eri Kawakami, Sawako Tatsumi, Yasuhiro Hamada, Ken-ichi Miyamoto
  • Journal Title: J Med Invest. Volume: 61(1.2) Pages: 162-70
  • NAID: 130004822704
  • Peer Reviewed
• [Presentation] CKD-MBDからの栄養管理 (2014)
  • Author(s): 濱田康弘
  • Organizer: 第29回ROD21研究会
  • Place of Presentation: 徳島グランヴィリオホテル（徳島県徳島市）
  • Invited
• [Presentation] 食品中リンの生体利用率の評価 (2014)
  • Author(s): 松浦明香、竹谷豊、森西真由美、米田武志、山崎通世、勝本美咲、濱田康弘、武田英二
  • Organizer: 第57回日本腎臓学会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
• [Book] Systems Biology of Free Radicals and Antioxidants (2015)
  • Author(s): Yasuhiro Hamada, Sonoko Yasui, Makoto Usami
  • Total Pages: 4106
  • Publisher: Springer
• [Book] ミネラル摂取と老化制御 (2014)
  • Author(s): 濱田康弘、安井苑子（分担執筆）
  • Total Pages: 165
  • Publisher: 建帛社
• [Book] Systems Biology of Free Radicals and Antioxidants (2014)
  • Author(s): Yasuhiro Hamada, Sonoko Yasui, Makoto Usami （分担執筆）
  • Total Pages: 4178
  • Publisher: Springer