| Project/Area Number |
25461570
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
太田 啓介 久留米大学, 医学部, 准教授 (00258401)
馬田 敏幸 産業医科大学, 教育研究支援施設, 准教授 (30213482)
御船 弘治 久留米大学, 医学部, 准教授 (70174117)
那須 沙織 久留米大学, 医学部, 研究員 (90754359)
松石 豊次郎 久留米大学, 付置研究所, 教授 (60157237)
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| Co-Investigator(Renkei-kenkyūsha) |
KOJIMA Masayasu 久留米大学, 分子生命科学研究所, 教授 (20202062)
SATOU Motoyasu 獨協医科大学, 生化学, 助教 (20418891)
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| Research Collaborator |
NASU Saori 久留米大学, 医学部・放射線同元素施設, 研究員 (90754359)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | グレリン / レット症候群 / 骨髄移植 / 放射線障害 / 放射性障害 / 骨髄抑制 / 疾患モデルマウス / ｸﾞﾚﾘﾝ / 放射線防御効果 / X-線照射 / ﾚｯﾄ症候群 / デカン酸修飾型グレリン / 脳発達 / 発達障害 / トランスレーショナルリサーチ |
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| Outline of Final Research Achievements |
Rett syndrome(RTT) is a congenital neurodeveropmental disease with glial disfunction. Derecki NC reported that, in RTT-model mice (RTT mice), an exchange of abnorlmal glial cells to normal ones by bone marrow transplantation (BMT) partially ameliorated neuronal disoders together with an elongation of thier life-span. Ghrelin, a brain-and-gut hormone, has been reported to calm down the hyper-excited glial cells through the functional ghrelin-receptor on them. In this study, we injected ghrelin once a day for 14 days to BMT-treated or non-BMT-tereated RTT mice and checked thier neuronal phenotype according to the method of Derecki NC. We also checked their life-span. In BMT-RTT mice with or without ghrelin-injection, we could find out no significant evidence for the elongation of life-span nor amelioration of neuronal condition in comparison to non-BMT RTT mice. Although, in non-BMT RTT mice with ghrelin-treatment, significant improvement of their neuronal condition was revealed.
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