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Development of diagnostic biomarker of mitochondrial disorders

Research Project

Project/Area Number 25461571
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionKurume University

Principal Investigator

KOGA Yasutoshi  久留米大学, 医学部, 教授 (00225400)

Co-Investigator(Kenkyū-buntansha) YATSUGA Shuichi  久留米大学, 医学部小児科, 助教 (10454919)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsミトコンドリア脳筋症 / バイオマーカー / 感度・特異度 / GDF15 / 診断アルゴリズム / 体外診断薬開発 / 重症度分類 / 薬物治療 / 効果判定 / 高乳酸血症 / メタボローム解析 / 診断システム / ミトコンドリア病 / 医薬品開発 / 評価指標 / 創薬研究
Outline of Final Research Achievements

Mitochondrial disorders, an intractable genetic disease, is the disorders who have not produce enough ATP generation. Using rho zero cellular model, we have identified GDF15, which is the most useful and reliable mitochondrial biomarker for diagnosis and monitor the clinical progression in mitochondrial disorders. We have been developing the testing device of GDF15 and doing the clinical trial for application for diagnostic device in Japan.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (36 results)

All 2016 2015 2014 2013

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 5 results,  Acknowledgement Compliant: 4 results) Presentation (23 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (3 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders.2015

    • Author(s)
      Yatsuga S, Fujita Y, Ishii A, Fukumoto Y, Arahata H, Kakuma T, Kojima T, Ito M, Tanaka M, Saiki R, Koga Y.
    • Journal Title

      Ann Neurol

      Volume: 78 Issue: 5 Pages: 814-823

    • DOI

      10.1002/ana.24506

    • NAID

      120007135881

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] (2014) GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases2015

    • Author(s)
      Yasunori Fujita, Masafumi Ito, Toshio Kojima, Shuichi Yatsuga, Yasutoshi Koga, Masashi Tanaka
    • Journal Title

      Mitochondrion

      Volume: 20 Pages: 34-42

    • DOI

      10.1016/j.mito.2014.10.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans.2015

    • Author(s)
      Wei FY, Zhou B, Suzuki T, Miyata K, Ujihara Y, Horiguchi H, Takahashi N, Xie P, Michiue H, Fujimura A, Kaitsuka T, Matsui H, Koga Y, Mohri S, Suzuki T, Oike Y, Tomizawa K.
    • Journal Title

      Cell Metab

      Volume: 21 Issue: 3 Pages: 413-6

    • DOI

      10.1016/j.cmet.2015.01.019

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] New TRPM6 mutation and management of hypomagnesaemia with secondary hypocalcaemia.2015

    • Author(s)
      Katayama K, Povalko N, Yatsuga S, Nishioka J, Kakuma T, Matsuishi T, Koga Y.
    • Journal Title

      Brain Dev.

      Volume: 37 Issue: 3 Pages: 292-298

    • DOI

      10.1016/j.braindev.2014.06.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Efficacy of pyruvate therapy in patients with mitochondrial disease: a semi-quantitative clinical evaluation study.2014

    • Author(s)
      Fujii T, Nozaki F, Saito K, Hayashi A, Nishigaki Y, Murayama K, Tanaka M, Koga Y, Hiejima I, Kumada T.
    • Journal Title

      Mol Genet Metab

      Volume: 112 Issue: 2 Pages: 133-138

    • DOI

      10.1016/j.ymgme.2014.04.008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ミトコンドリア脳筋症治療の現状と展望2014

    • Author(s)
      古賀靖敏
    • Journal Title

      日本臨床

      Volume: 72 Pages: 175-184

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of pyruvate therapy in patients with mitochondrial disease: a semi-quantitative clinical evaluation study2014

    • Author(s)
      Fujii T, et al.
    • Journal Title

      Molecular Genetics and Metabolism

      Volume: 112 Pages: 889-895

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] GDF15 as the most reliable biomarker for mitochondrial disorders2016

    • Author(s)
      Yasutoshi Koga, Shuichi Yatsuga, Akiko Ishii, Tatsuyuki Kakuma, Masashi Tanaka
    • Organizer
      Biomarker Summit 2016
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] GDF15 はミトコンドリア病の新規バイオマーカーとして有用2016

    • Author(s)
      八ツ賀秀一、石井亜紀子、藤田泰典、小島俊男、伊藤雅史、田中雅嗣、角間辰之、古賀靖敏
    • Organizer
      第8回福岡県医学会総会
    • Place of Presentation
      福岡県医師会館(福岡市)
    • Year and Date
      2016-02-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] ピルビン酸ナトリウム治療はミトコンドリア病の臨床症状および乳酸・GDF-15を改善する2015

    • Author(s)
      古賀靖敏、八ッ賀秀一、齊木玲央、田中雅嗣
    • Organizer
      第15回日本ミトコンドリア学会年会
    • Place of Presentation
      福井県国際交流会館(福井市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] ミトコンドリア病類縁疾患におけるGDF15・FGF21の検討2015

    • Author(s)
      八ツ賀秀一、石井亜紀子、喜多村美幸、佐々木孝子、牛嶋規久美、齊木玲央、古賀靖敏
    • Organizer
      第15回日本ミトコンドリア学会年会
    • Place of Presentation
      福井県国際交流会館(福井市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] ピルビン酸ナトリウム治療はミトコンドリア病の臨床症状および乳酸・GDF-15を改善する2015

    • Author(s)
      古賀靖敏、八ッ賀秀一、齊木玲央、田中雅嗣
    • Organizer
      第57回日本先天代謝異常学会総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] GDF-15とFGF-21はミトコンドリア病の重症度と相関する2015

    • Author(s)
      八ツ賀秀一、角間辰之、古賀靖敏
    • Organizer
      第57回日本小児神経学会学術集会
    • Place of Presentation
      帝国ホテル 大阪(大阪市)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] GDF-15:最も信頼できるミトコンドリア病のバイオマーカー2015

    • Author(s)
      八ツ賀秀一、石井亜紀子、角間辰之、古賀靖敏
    • Organizer
      第57回日本小児神経学会学術集会
    • Place of Presentation
      帝国ホテル 大阪(大阪市)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 健康な日本人におけるFGF21の検討2015

    • Author(s)
      八ツ賀秀一、佐々木孝子、西岡淳子、片山幸樹、牛嶋規久美、古賀靖敏
    • Organizer
      第88回日本内分泌学会学術総会
    • Place of Presentation
      ホテルニューオータニ東京(東京都)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] GDF15 (growth differentiation factor 15) is the new biomarker for muscle-related mitochondrial diseases2015

    • Author(s)
      Shuichi Yatsuga, Akiko Ishii, Hajime Arahata, Yoshihiro Fukumoto, Masashi Tanaka, Yasutoshi Koga
    • Organizer
      The 67th American Academy of Neurology Annual Meeting
    • Place of Presentation
      Washington, U.S.A.
    • Year and Date
      2015-04-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] GDF15 is a novel biomarker of mitochondrial diseases2015

    • Author(s)
      Shuichi Yatsuga, Akiko Ishii, Yoshihiro Fukumoto, Hajime Arahata, Tatsuyuki Kakuma, Yasutoshi Koga
    • Organizer
      Society for Inherited Metabolic Disorders 2015
    • Place of Presentation
      Grand America Hotel (Salt Lake City)
    • Year and Date
      2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] GDF-15&FGF-21:ミトコンドリア病の新規バイオマーカー2014

    • Author(s)
      八ツ賀秀一, 石井亜紀子, 藤田泰典, 小島俊男, 伊藤雅史, 田中雅嗣, 角間辰之, 古賀靖敏
    • Organizer
      第14回日本ミトコンドリア学会年会
    • Place of Presentation
      九州大学医学部百年講堂(福岡県福岡市)
    • Year and Date
      2014-12-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of therapeutic drug of sodium pyruvate (SP) for lactic acidosis associated with mitochondrial disorders2014

    • Author(s)
      Yasutoshi Koga
    • Organizer
      11th Conference of Asian Society for Mitohondrial Research & Medicine
    • Place of Presentation
      Grand Hyatt Taipei (Taipei, Taiwan)
    • Year and Date
      2014-11-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] GDF15はミトコンドリア病の新しいバイオマーカーになる2014

    • Author(s)
      八ツ賀秀一、古賀靖敏
    • Organizer
      第56回日本先天代謝異常学会
    • Place of Presentation
      江陽グランドホテル(宮城県仙台市)
    • Year and Date
      2014-11-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 健康日本人の血漿FGF21値の検討2014

    • Author(s)
      八ツ賀秀一、佐々木孝子、古賀靖敏
    • Organizer
      第48回日本小児内分泌学会学術集会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2014-09-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Growth Differentiation Factor 15 and Fibroblast Growth Factor 21: Novel Biomarkers for Mitochondrial Diseases2014

    • Author(s)
      Shuichi Yatsuga, Yasutoshi Koga
    • Organizer
      53rd Annual ESPE Meeting
    • Place of Presentation
      Convention Centre Dublin (Dublin, Ireland)
    • Year and Date
      2014-09-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Growth differentiation factor 15 and fibroblast growth factor 21: novel biomarkers for mitochondrial diseases2014

    • Author(s)
      Shuichi Yatsuga, Yasutoshi Koga
    • Organizer
      EuroMIT 2014
    • Place of Presentation
      Tampere Hall (Tampere, Finland)
    • Year and Date
      2014-06-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Growth differentiation factor 15 and fibroblast growth factor 21: novel biomarkers for mitochondrial diseases2014

    • Author(s)
      Shuichi Yatsuga, Yasutoshi Koga
    • Organizer
      Mitochondrial Medicine 2014
    • Place of Presentation
      Sheraton Station Square Hotel (Pittsburgh, USA)
    • Year and Date
      2014-06-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of therapeutic drug of Sodium Pyruvate (SP) for lactic acidosis associated with mitochondrial disorders2014

    • Author(s)
      Yasutoshi Koga
    • Organizer
      Mitochondrial Medicine 2014
    • Place of Presentation
      Sheraton Station Square Hotel (Pittsburgh, USA)
    • Year and Date
      2014-06-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 血漿FGF21は筋症状を伴うミトコンドリア病のバイオマーカーになる2014

    • Author(s)
      八ツ賀秀一、古賀靖敏
    • Organizer
      第56回日本小児神経学会学術集会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2014-05-31
    • Related Report
      2014 Research-status Report
  • [Presentation] ミトコンドリア病治療研究の現状2014

    • Author(s)
      古賀靖敏
    • Organizer
      第56回日本小児神経学会学術集会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2014-05-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Pharmacologic Therapy for Mitochondrial Myopathies2014

    • Author(s)
      Yasutoshi Koga
    • Organizer
      The Joint 13th AOMC Annual Scientific Meeting and 20th PNA Midyear Convention
    • Place of Presentation
      Dusit Thani Hotel (Manila, Philippines)
    • Year and Date
      2014-05-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ピルビン酸ナトリウムを開始したミトコンドリア呼吸鎖異常症の6か月男児2014

    • Author(s)
      金城さおり、豊浦麻記子、吉年俊文、喜久山至、小濱守安、閑野将行、源川隆一、八ツ賀秀一、古賀靖敏
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] ミトコンドリア脳筋症に合併する高乳酸血症に対するピルビン酸ナトリウム治療法の開発2014

    • Author(s)
      古賀靖敏、ピルビン酸ナトリウム治療法開発チーム
    • Organizer
      第117回日本小児科学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2014-04-11
    • Related Report
      2014 Research-status Report
  • [Book] 代謝性ミオパチー Basic mechanism, Diagnosis and Practical Approach2014

    • Author(s)
      古賀 靖敏
    • Publisher
      診断と治療社
    • Related Report
      2014 Research-status Report
  • [Book] 引いて調べる 先天代謝異常症2014

    • Author(s)
      古賀 靖敏
    • Publisher
      診断と治療社
    • Related Report
      2014 Research-status Report
  • [Book] 心エコーハンドブック 心筋・心膜疾患2014

    • Author(s)
      古賀 靖敏、工藤嘉公
    • Publisher
      金芳堂
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] ミトコンドリア病診断用バイオマーカーとしてのGDF152014

    • Inventor(s)
      田中雅嗣、古賀靖敏他
    • Industrial Property Rights Holder
      田中雅嗣、古賀靖敏他
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-005391
    • Filing Date
      2014-04-01
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] ミトコンドリア病診断用バイオマーカーとしてのGDF152014

    • Inventor(s)
      田中雅嗣、古賀靖敏他
    • Industrial Property Rights Holder
      田中雅嗣、古賀靖敏他
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-04-01
    • Related Report
      2014 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] ミトコンドリア病診断用バイオマーカーとしてのGDF152013

    • Inventor(s)
      古賀靖敏他、
    • Industrial Property Rights Holder
      古賀靖敏他、
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-10-28
    • Related Report
      2013 Research-status Report
    • Overseas

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Published: 2014-07-25   Modified: 2019-07-29  

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