Mechanisms of hair graying

• Project/Area Number: 25461717
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Nagoya University (2014-2016); Chubu University (2013)
• Principal Investigator: IIDA Machiko 名古屋大学, 医学系研究科, 特任助教 (60465515)
• Co-Investigator(Kenkyū-buntansha): 武田 湖州恵 中部大学, 生命健康科学部, 准教授 (80345884) ; 大神 信孝 名古屋大学, 医学(系)研究科(研究院), 講師 (80424919)
• Co-Investigator(Renkei-kenkyūsha): YAJIMA Ichiro 名古屋大学, 大学院医学系研究科, 講師 (80469022)
• Research Collaborator: SATO Awoi 名古屋大学, 大学院医学系研究科, 技術補佐員
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: メラノサイト / 幹細胞 / 毛髪 / 皮膚 / 加齢性疾患 / エイジング

Outline of Final Research Achievements

Hair graying is a symbol of aging. However, the mechanisms underlying age-related hair graying have not yet been fully clarified. In this study, we examined the mechanisms of age-related hair graying using our novel model mice, in which progressive hair graying is observed with age. Follicular melanocyte stem cells are known to be a melanocyte reservoir in hair follicles. We observed the elimination of follicular melanocyte stem cells in hair follicles with age in our model mice. Furthermore, our results suggested that interactions between melanocyte stem cells and keratinocyte stem cells through an endocrine protein is involved in age-related hair graying in our model mice.

Research Products

• [Journal Article] Different biological effects of a constant dose for single UVB irradiation with different intensities and exposure times. (2016)
  • Author(s): Iida M, Nakano C, Tamaki M, Hasegawa M, Tsuzuki T and Kato M.
  • Journal Title: Exp Dermatol Volume: in press Issue: 5 Pages: 386-8
  • DOI: 10.1111/exd.12969
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Modulated expression levels of tyrosine kinases in spontaneously developed melanoma by single irradiation of non-thermal atmospheric pressure plasmas. (2016)
  • Author(s): Omata Y, Iida M, Yajima I, Ohgami N, Oshino R, Maeda M, Ninomiya H, Tsuzuki T, Hori M, Kato M.
  • Journal Title: Int J Clin Exp Pathol. Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation. (2016)
  • Author(s): Kawamoto Y, Ueno Y, Nakahashi E, Obayashi M, Sugihara K, Qiao S, Iida M, Kumasaka MY, Yajima I, Goto Y, Ohgami N, Kato M, Takeda K
  • Journal Title: J Nutr Biochem Volume: 27 Pages: 112-122
  • DOI: 10.1016/j.jnutbio.2015.08.025
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Transcription factor LSF (TFCP2) inhibits melanoma growth. (2016)
  • Author(s): Goto Y, Yajima I, Kumasaka M, Ohgami N, Tanaka A, Tsuzuki T, Inoue Y, Fukushima S, Ihn H, Kyoya M, Ohashi H, Kawakami T, Bennett DC, Kato M.
  • Journal Title: Oncotarget. Volume: 19 Issue: 3 Pages: 2739-2790
  • DOI: 10.18632/oncotarget.6230
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of Preventive Therapy by Clarification of Mechanisms of Environmental-Factor-Mediated Diseases (2015)
  • Author(s): Kato M, Omata Y, Iida M, Y Kumasaka M, Ohgami N, Li X, Zou C, Nakano C, Kato Y, Ohgami K, Ohnuma S, Yajima I.
  • Journal Title: Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) Volume: 70 Issue: 3 Pages: 176-180
  • DOI: 10.1265/jjh.70.176
  • NAID: 130005098969
  • ISSN: 0021-5082, 1882-6482
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of Environmental-Stress-Related Impairments of Inner Ear. (2015)
  • Author(s): Ohgami N, Iida M, Omata Y, Nakano C, Wenting W, Li X, Kato M.
  • Journal Title: Nihon Eiseigaku Zasshi. Volume: 70(2) Pages: 100-104
  • NAID: 130005070847
  • Peer Reviewed / Open Access
• [Journal Article] Decreased expression levels of cell cycle regulators and matrix metalloproteinases in melanoma from RET-transgenic mice by single irradiation of non-equilibrium atmospheric pressure plasmas. (2015)
  • Author(s): Iida M, Omata Y, Nakano C, Yajima I, Tsuzuki T, Ishikawa K, Hori M, Kato M.
  • Journal Title: Int J Clin Exp Pathol. Volume: 8(8) Pages: 9326-9331
  • Peer Reviewed / Open Access
• [Journal Article] Plasma with high electron density and plasma-activated medium for cancer treatment (2015)
  • Author(s): H. Tanaka, M. Mizuno, K. Ishikawa, H. Kondo, K. Takeda, H. Hashizume, K. Nakamura, F. Utsumi, H. Kajiyama, H. Kano, Y. Okazaki, S. Toyokuni, S. Akiyama, S. Maruyama, S. Yamada, Y. Kodera, H. Kaneko, H. Terasaki, H. Hara, T. Adachi, M. Iida, I. Yajima, M. Kato, F. Kikkawa, M. Hori
  • Journal Title: Clinical Plasma Medicine Volume: 3 Issue: 2 Pages: 72-76
  • DOI: 10.1016/j.cpme.2015.09.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Arsenic-mediated promotion of anchorage-independent growth through increased level of placental growth factor. (2015)
  • Author(s): Yajima I, Kumasaka MY, Ohnuma S, Ohgami N, Naito H, Shekhar HU, Omata Y, Kato M.
  • Journal Title: J Invest Dermatol Volume: 135 Issue: 4 Pages: 1147-1156
  • DOI: 10.1038/jid.2014.514
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of non-thermal atmospheric pressure plasma irradiation on expression levels of matrix metalloproteinases in benign melanocytic tumors in RET-transgenic mice. (2014)
  • Author(s): Iida M,Yajima I, Ohgami N, Tamura H, Takeda K, Ichihara S, Hori M, Kato M.
  • Journal Title: Eur J Dermatol Volume: 24 Issue: 3 Pages: 392-394
  • DOI: 10.1684/ejd.2014.2330
  • Peer Reviewed / Open Access
• [Journal Article] Non-equilibrium atmospheric pressure plasmas modulate cell cycle-related gene expressions in melanocytic tumors of RET-transgenic mice. (2014)
  • Author(s): Yajima I, Iida M, Kumasaka MY, Omata Y, Ohgami N, Chang J, Ichihara S, Hori M, Kato M.
  • Journal Title: Exp Dermatol Volume: 23 Issue: 6 Pages: 424-425
  • DOI: 10.1111/exd.12415
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Non-thermal atmospheric pressure plasmas as a novel candidate for preventive therapy of melanoma. (2014)
  • Author(s): Omata Y, Iida M, Yajima I, Takeda K, Ohgami N, Masaru Hori H, Kato M.
  • Journal Title: Environ Health Prev Med. Volume: 19 Issue: 5 Pages: 367-369
  • DOI: 10.1007/s12199-014-0399-1
  • NAID: 50009312844
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Commentary to Pastore et al (2014): Epidermal growth factor receptor signalling in keratinocyte biology: implications for skin toxicity of tyrosine kinase inhibitors (2014)
  • Author(s): K. Takeda, Y. Kawamoto, M. Iida, Y. Omata, C. Zou, M. Kato
  • Journal Title: Arch Toxicol Volume: 88 Issue: 12 Pages: 2319-2320
  • DOI: 10.1007/s00204-014-1373-9
  • Peer Reviewed
• [Journal Article] Commentary to Krishna et al. (2014): brain deposition and neurotoxicity of manganese in adult mice exposed via the drinking water. (2014)
  • Author(s): Kumasaka MY, Yajima I, Ohgami N, Naito H, Omata, Kato M.
  • Journal Title: Arch Toxicol Volume: 88 Issue: 5 Pages: 1185-1186
  • DOI: 10.1007/s00204-014-1221-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] GNG2 inhibits invasion of human malignant melanoma cells with decreased FAK activity (2014)
  • Author(s): Yajima I, Kumasaka MY, Yamanoshita O, Zou C, Li X, Ohgami N, Kato M.
  • Journal Title: Am J Cancer Res Volume: 4 Pages: 182-188
  • Peer Reviewed
• [Journal Article] Hearing impairments caused by genetic and environmental factors. (2013)
  • Author(s): Ohgami N, et al.
  • Journal Title: Environ Health Prev Med. Volume: 18 Issue: 1 Pages: 10-15
  • DOI: 10.1007/s12199-012-0300-z
  • NAID: 10031143686
  • Peer Reviewed
• [Presentation] メラノーマを自然発症する2種類のモデルマウスの紹介と非熱プラズマによる抗腫瘍効果の検討 (2015)
  • Author(s): 飯田 真智子，小又 尉広，加藤 昌志
  • Organizer: 「プラズマ医療科学の創成」＋「統合的神経機能の制御を標的とした糖鎖の作動原理解明」合同公開シンポジウム
  • Place of Presentation: 名古屋大学野依記念学術交流館（愛知県名古屋市）
  • Year and Date: 2015-08-05
  • Invited
• [Presentation] モデル動物を用いたメラノーマ予防・治療法の開発 (2014)
  • Author(s): 飯田真智子、矢嶋伊知朗、熊坂真由子、神保佳奈、田村青鳥、大神信孝、加藤昌志
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター(岡山県・岡山市）
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] バリウムの発癌毒性 (2014)
  • Author(s): 飯田真智子、矢嶋伊知朗、熊坂真由子、大沼章子、神保 佳奈、田村青鳥、大神信孝、加藤昌志
  • Organizer: 第87回日本産業衛生学会
  • Place of Presentation: 岡山コンベンションセンター(岡山県・岡山市）
  • Year and Date: 2014-05-21 – 2014-05-24
• [Presentation] バリウムの発癌毒性 (2014)
  • Author(s): 飯田真智子、矢嶋伊知郎、熊坂真由子、大沼章子、神保佳奈、田村青鳥、大神信孝、加藤昌志
  • Organizer: 第87回 日本産業衛生学会
  • Place of Presentation: 岡山コンベンションセンター
• [Presentation] モデル動物を用いたメラノーマ予防・治療法の開発 (2014)
  • Author(s): 飯田真智子、矢嶋伊知郎、熊坂真由子、神保佳奈、田村青鳥、大神信孝、加藤昌志
  • Organizer: 第84回 日本衛生学会
  • Place of Presentation: 岡山コンベンションセンター
• [Book] 化粧品技術者のための素材開発実験プロトコール集 (2015)
  • Author(s): 京谷大毅、横田真理子、坂本一民、山下裕司、井筒ゆき子、小幡誉子、松本雅之、藤代美有紀、多田明弘、日比野利彦、梅田麻衣、菅原智子、丹野修、矢作彰一、行卓男、波多野豊、木田尚子、矢田幸博、山下由貴、飯田真智子
  • Total Pages: 347
  • Publisher: シーエムシー出版
• [Remarks] 名古屋大学大学院医学系研究科 環境労働衛生学 ホームページ
  • URL: http://www.med.nagoya-u.ac.jp/hygiene/
• [Remarks] 名古屋大学大学院医学系研究科 環境労働衛生学 ホームページ
  • URL: http://www.med.nagoya-u.ac.jp/hygiene/