Establishment of optimal dose schedule with high precision definitive radiotherapy for patients with uterine cervical cancer
Project/Area Number |
25461919
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | University of the Ryukyus |
Principal Investigator |
Takafumi TOITA 琉球大学, 医学(系)研究科(研究院), 准教授 (30237036)
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Co-Investigator(Kenkyū-buntansha) |
KASUYA Goro 琉球大学, 医学部附属病院, 医員 (00639932)
OHNO Tatsuya 群馬大学, 学内共同利用施設等, 教授 (10344061)
KAKINOHANA Yasumasa 琉球大学, 大学院医学研究科, 助教 (20185713)
TAKASHI Uno 千葉大学, 医学研究科, 教授 (30302540)
SATOSHI Ishikura 順天堂大学, 医学部, その他 (40407242)
ARIGA Takuro 琉球大学, 医学部附属病院, 助教 (60647337)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 子宮頸癌 / 放射線治療 / 高線量率腔内照射 / 臨床試験 / IGBT / 画像誘導小線源治療 / 強度変調放射線治療 |
Outline of Final Research Achievements |
Definitive radiotherapy (RT) and chemoradiotherapy (CRT) are now considered a global standard of treatment for patients with uterine cervical cancer. In RT/CRT, the difference in total radiotherapy dose between Japan and other countries has been a critical issue. We conducted two multi-institutional clinical trials to evaluate the clinical results with the Japanese dose, and we demonstrated favorable outcomes with less severe toxicities. However, some international investigators criticized these results because there was uncertainty about the dose evaluation for the Japanese external beam RT that uses central shielding. In order to remove the doubts, we developed a clinical study adopting a new external beam RT protocol without central shielding, and we have started recruiting patients.
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] Proposed definition of the vaginal cuff and paracolpium clinical target volume in postoperative uterine cervical cancer.2016
Author(s)
Murakami N, Norihisa Y, Isohashi F, Murofushi K, Ariga T, Kato T, Inaba K, Okamoto H, Ito Y, Toita T, Itami J.
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Journal Title
Pract Radiat Oncol.
Volume: 6
Issue: 1
Pages: 5-11
DOI
Related Report
Peer Reviewed
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[Journal Article] A surveillance study of intensity-modulated radiation therapy for postoperative cervical cancer in Japan.2015
Author(s)
Murakami N, Okamoto H, Isohashi F, Murofushi K, Ohno T, Yoshida D, Saito M, Inaba K, Ito Y, Toita T, Itami J.
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Journal Title
J Radiat Res.
Volume: 56
Issue: 4
Pages: 735-741
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Concurrent use of strontium-89 with external beam radiotherapy for multiple bone metastases: early experience.2015
Author(s)
Heianna J, Toita T, Endo W, Kasuya G, Ariga T, Hashimoto S, Maemoto H, Terui K, Miura N, Togashi A, Miyauchi T, Murayama S.
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Journal Title
Ann Nucl Med.
Volume: 29
Issue: 10
Pages: 848-853
DOI
Related Report
Peer Reviewed
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[Journal Article] A dosimetric analysis of intensity-modulated radiation therapy with bone marrow sparing for cervical cancer.2014
Author(s)
Murakami N, Okamoto H, Kasamatsu T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Takahashi K, Yoshio K, Inaba K, Morota M, Sumi M, Toita T, Ito Y, Itami J.
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Journal Title
Anticancer Res.
Volume: 34
Pages: 5091-8
Related Report
Peer Reviewed
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[Journal Article] Prediction of concurrent chemoradiotherapy outcome in advanced oropharyngeal cancer.2014
Author(s)
Hasegawa M, Maeda H, Deng Z, Kiyuna A, Ganaha A, Yamashita Y, Matayoshi S, Agena S, Toita T, Uehara T, Suzuki M.
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Journal Title
Int J Oncol
Volume: 45
Issue: 3
Pages: 1017-26
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Tomita N, Kodaira T, Teshima T, Ogawa K, Kumazaki Y, Yamauchi C, Toita T, Uno T, Sumi M, Onishi H, Kenjo M, Nakamura K.2014
Author(s)
Tomita N, Kodaira T, Teshima T, Ogawa K, Kumazaki Y, Yamauchi C, Toita T, Uno T, Sumi M, Onishi H, Kenjo M, Nakamura K.
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Journal Title
Jpn J Clin Oncol
Volume: 44
Issue: 6
Pages: 579-86
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Distribution patterns of metastatic pelvic lymph nodes assessed by CT/MRI in patients with uterine cervical cancer.2013
Author(s)
Kasuya G, Toita T, Furutani K, Kodaira T, Ohno T, Kaneyasu Y, Yoshimura R, Uno T, Yogi A, Ishikura S, Hiraoka M.
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Journal Title
Radiat Oncol.
Volume: 8
Issue: 1
Pages: 138-138
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] ostoperative radiotherapy for uterine cervical cancer: impact of lymph node and histological type on survival.2013
Author(s)
Kasuya G, Ogawa K, Iraha S, Nagai Y, Hirakawa M, Toita T, Kakinohana Y, Kudaka W, Inamine M, Ariga T, Aoki Y, Murayama S.
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Journal Title
Anticancer Res.
Volume: 33
Pages: 2199-2204
Related Report
Peer Reviewed
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[Journal Article] High-dose-rate Intra-cavitary Brachytherapy Combined with External Beam Radiation Therapy for Under 40-Year-old Patients with Invasive Uterine Cervical Carcinoma: Clinical Outcomes in 118 Patients in a Japanese Multi-institutional Study, JASTRO.2013
Author(s)
Yamashita H, Niibe Y, Toita T, Kazumoto T, Nishimura T, Kodaira T, Eto H, Kinoshita R, Tsujino K, Onishi H, Takemoto M, Hayakawa K.
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Journal Title
Jpn J Clin Oncol.
Volume: 43
Pages: 547-552
Related Report
Peer Reviewed
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[Presentation] 子宮がんの放射線治療2014
Author(s)
戸板孝文
Organizer
西日本がんプロ合同市民公開シンポジウム.
Place of Presentation
福岡国際会議場(福岡市)
Year and Date
2014-10-18
Related Report
Invited
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[Presentation] 子宮頸癌の放射線治療2014
Author(s)
戸板孝文
Organizer
東北大学病院がんセミナー
Place of Presentation
東北大学病院(仙台市)
Year and Date
2014-05-15
Related Report
Invited
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