| Project/Area Number |
25461919
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Takafumi TOITA 琉球大学, 医学(系)研究科(研究院), 准教授 (30237036)
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| Co-Investigator(Kenkyū-buntansha) |
KASUYA Goro 琉球大学, 医学部附属病院, 医員 (00639932)
OHNO Tatsuya 群馬大学, 学内共同利用施設等, 教授 (10344061)
KAKINOHANA Yasumasa 琉球大学, 大学院医学研究科, 助教 (20185713)
TAKASHI Uno 千葉大学, 医学研究科, 教授 (30302540)
SATOSHI Ishikura 順天堂大学, 医学部, その他 (40407242)
ARIGA Takuro 琉球大学, 医学部附属病院, 助教 (60647337)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 子宮頸癌 / 放射線治療 / 高線量率腔内照射 / 臨床試験 / IGBT / 画像誘導小線源治療 / 強度変調放射線治療 |
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| Outline of Final Research Achievements |
Definitive radiotherapy (RT) and chemoradiotherapy (CRT) are now considered a global standard of treatment for patients with uterine cervical cancer. In RT/CRT, the difference in total radiotherapy dose between Japan and other countries has been a critical issue. We conducted two multi-institutional clinical trials to evaluate the clinical results with the Japanese dose, and we demonstrated favorable outcomes with less severe toxicities. However, some international investigators criticized these results because there was uncertainty about the dose evaluation for the Japanese external beam RT that uses central shielding. In order to remove the doubts, we developed a clinical study adopting a new external beam RT protocol without central shielding, and we have started recruiting patients.
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