Influence of Klotho produced from transplanted kidneys on mineral metabolism and graft/patient survival in kidney transplant patients
| Project/Area Number |
25461962
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKAGAWA Masafumi 東海大学, 医学部, 教授 (00211516)
KAKUTA Takatoshi 東海大学, 医学部, 教授 (50276854)
SHIRAI Hiroyuki 東海大学, 医学部, 助教 (90346338)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Klotho / 腎移植 / ミネラル代謝 |
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| Outline of Final Research Achievements |
This study was designed to elucidate how Klotho, which is produced by the kidney graft, functions in kidney transplant patients and its influence on mineral metabolism and graft/patient survival. We measured serum soluble Klotho levels pre- and postoperatively from kidney transplant recipients and their donors. In kidney transplant recipients, we found that soluble Klotho levels decreased postoperatively from the preoperative level and a tendency to recover at three to six months was observed. In living donors, the soluble Klotho level decreased after an operation, and only in a small number of cases did the level return to the preoperative value. It was suggested that the soluble Klotho level improved through a successful kidney graft, but considerable differences were found among cases.
We are proceeding with the study on the parathyroid gland, which also produces Klotho, to characterize the pathological difference between pre- and postoperative kidney transplant patients.
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Report
(4 results)
Research Products
(10 results)
