| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
The aim of this study is to compare mucinous cystic neoplasm (MCN), pancreatic invasive ductal carcinoma (DC), and normal pancreas to clarify the roles of ER in the development and progression of MCN. The expression of estrogen receptor (ER-alpha, ER-beta1), corepressor (N-CoR), coactivator (AIB-1, SRC-1), phosphorylation site (Ser106, Ser118, Ser167) were evaluated immunohistochemically.
On tumor epithelial cells, the expression of ER-beta1 was significantly more frequently positive in MCN than in DC and normal pancreas. Furthermore, on stromal cells, the expressions of ER-alpha, ER-beta1 were significantly more frequently positive in MCN than in DC and normal pancreas. In MCN the expression of SRC-1, Ser106, and Ser118 were frequently positive on both tumor epithelial cells and stromal cells. In MCN, ER may play a major role in the development and progression. In particular, it was suggested that ER was activated without depending on the ligand in itself.
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