Role of the estorogen receptor for development and progression of mucinous cystic neoplasm of the pancreas

Research Project

Project/Area Number	25462125
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Digestive surgery
Research Institution	Kyorin University
Principal Investigator	Suzuki Yutaka 杏林大学, 医学部, 助教 (30407001)
Co-Investigator(Kenkyū-buntansha)	SUGIYAMA Masanori 杏林大学, 医学部外科学, 教授 (20192825) ABE Nobutsugu 杏林大学, 医学部外科学, 准教授 (40266747)
Co-Investigator(Renkei-kenkyūsha)	OHKURA Yasuo 杏林大学, 医学部病理学教室, 教授 (30312284)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000) Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords	膵腫瘍の分子生物学的研究
Outline of Final Research Achievements	The aim of this study is to compare mucinous cystic neoplasm (MCN), pancreatic invasive ductal carcinoma (DC), and normal pancreas to clarify the roles of ER in the development and progression of MCN. The expression of estrogen receptor (ER-alpha, ER-beta1), corepressor (N-CoR), coactivator (AIB-1, SRC-1), phosphorylation site (Ser106, Ser118, Ser167) were evaluated immunohistochemically. On tumor epithelial cells, the expression of ER-beta1 was significantly more frequently positive in MCN than in DC and normal pancreas. Furthermore, on stromal cells, the expressions of ER-alpha, ER-beta1 were significantly more frequently positive in MCN than in DC and normal pancreas. In MCN the expression of SRC-1, Ser106, and Ser118 were frequently positive on both tumor epithelial cells and stromal cells. In MCN, ER may play a major role in the development and progression. In particular, it was suggested that ER was activated without depending on the ligand in itself.