| Project/Area Number |
25462397
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Akita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Tetsu 秋田大学, 医学(系)研究科(研究院), 講師 (00312702)
GOYAGI Toru 秋田大学, 医学部, 講師 (30302277)
HORIGUCHI Takashi 秋田大学, 医学部, 准教授 (70221570)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 認知機能障害 / 全身麻酔 / セボフルラン / キセノン / デクスメデトミジン / リチウム / アポトーシス / 高次脳機能障害 / 術後認知機能障害 / α2受容体作動薬 / 神経毒性 |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the protective properties of dexmedetomidine, xenon, and lithium against cognitive dysfunction following sevoflurane anesthesia using aged rats. Although we used Morris water maze test to evaluate cognitive function, the function of aged rats could not be evaluated because their physical functions were severely impaired. Then, eight-arm radial maze test was used to evaluate cognitive function. However, it took months to train aged rats to determine baseline cognitive functions. Furthermore, the cognitive function was not altered by sevoflurane anesthesia though several combinations of sevoflurane concentration and duration were tested. Therefore, the protective properties of dexmedetomidine, xenon, or lithium against cognitive function were not investigated in this experimental period.
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