The effectiveness of erythropoietin for the pulmonary hypertension with the congenital diaphragmatic hernia patients
Project/Area Number |
25462769
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatric surgery
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Research Institution | University of Tsukuba |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MASUMOTO Kouji 筑波大学, 医学医療系, 教授 (20343329)
UESUGI Toru 筑波大学, 医学医療系, 講師 (30380421)
GOTOH Chikashi 筑波大学, 医学医療系, 講師 (80598889)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 先天性横隔膜ヘルニア / ラットモデル / 肺高血圧 / RhoA / エリスロポエチン / ナイトロフェン / Rhoキナーゼ / 横隔膜ヘルニア / Rho Kinase阻害剤 / Wntシグナル伝達系 |
Outline of Final Research Achievements |
Our results using nitrofen-induced congenital diaphragmatic hernia (CDH) provide evidence that the RhoA/Rho-kinase-mediated pathway is involved in the pathogenesis of PH in the nitrofen-induced CDH rat model. Our data also suggest that the fasudil, a Rho-kinase inhibitor, could represent a therapeutic option for the treatment of PH in CDH. We also found the suppressed EPO synthesis in the CDH fetus, which may contribute to the pathogenesis of lung hypoplasia and modification of pulmonary vasculature in the CDH rat model.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Japanese Congenital Diaphragmatic Hernia Study Group. Musculoskeletal abnormalities in congenital diaphragmatic hernia survivors: Patterns and risk factors: report of a Japanese multicenter follow-up survey.2016
Author(s)
Takayasu H, Masumoto K, Goishi K, Hayakawa M, Tazuke Y, Yokoi A, Terui K, Okuyama H, Usui N, Nagata K, Taguchi T
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Journal Title
Pediatr Int.
Volume: 未定
Issue: 9
Pages: 877-880
DOI
Related Report
Peer Reviewed
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[Journal Article] Increased pulmonary RhoA expression in the nitrofen-induced congenital diaphragmatic hernia rat model.2015
Author(s)
Takayasu H, Masumoto K, Hagiwara K, Sasaki T, Ono K, Jimbo T, Uesugi T, Gotoh C, Urita Y, Shinkai T, Tanaka H.
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Journal Title
J Pediatr Surg.
Volume: 50
Issue: 9
Pages: 1467-71
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Musculoskeletal Abnormalities in Congenital Diaphragmatic Hernia Survivors: Patterns and Risk Factors - Report From A Multicenter Follow-up Survey -2015
Author(s)
Hajime Takayasu, Kouji Masumoto, Keiji Goishi, Masahiro Hayakawa, Yuko Tazuke, Akiko Yokoi, Keita Terui, Hiroomi Okuyama, Noriaki Usui, Kouji Nagata, and Tomoaki Taguchi
Organizer
第52回日本小児外科学会
Place of Presentation
神戸国際会議場
Year and Date
2015-05-27
Related Report
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[Presentation] Suppressed Erythropyetin Expression in the Liver in Nitrofen-induced Congenital Diaphragmatic Hernia.2015
Author(s)
Hajime Takayasu, Kouji Masumoto, Koki Hagiwara, Takato Sasaki, Fumiko Chiba, Naoya Sakamoto, Chikashi Gotoh, Yasuhisa Urita, Makoto Nakao, Toko Shinkai, Hideaki Tanaka
Organizer
アジア太平洋小児外科学会2015
Place of Presentation
チェジュ島、韓国
Year and Date
2015-05-18
Related Report
Int'l Joint Research
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[Presentation] Suppressed Erythropyetin Expression in the Liver in Nitrofen-induced Congenital Diaphragmatic Hernia.2015
Author(s)
Hajime Takayasu, Kouji Masumoto, Koki Hagiwara, Shunsuke Fujii, Tsubasa Aiyoshi, Takato Sasaki, Fumiko Chiba, Naoya Sakamoto, Chikashi Gotoh, Yasuhisa Urita, Makoto Nakao, Toko Shinkai, Hideaki Tanaka
Organizer
太平洋小児外科学会
Place of Presentation
チェジュ島、韓国
Year and Date
2015-05-17 – 2015-05-21
Related Report
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