| Project/Area Number |
25463228
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
Saito Atsushi 東京歯科大学, 歯学部, 教授 (60266559)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA KAZUYUKI 東京歯科大学, 歯学部, 教授 (00212910)
KOKUBU EITOYO 東京歯科大学, 歯学部, 助教 (70453785)
TAKAYAMA SAORI 東京歯科大学, 歯学部, 助教 (00550013)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 歯肉上皮細胞 / 喫煙 / タバコ煙 / Porphyromonas gingivalis / 歯周病原細菌 / 細胞侵入 / 細胞骨格 / 創傷治癒 / P. gingivalis / 歯周炎 / 遊走能 |
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| Outline of Final Research Achievements |
Epithelial cells are recognized as the first line of defense against bacterial infection and environmental harmful stimuli such as cigarette smoke (CS). Currently, mechanisms by which CS affects cellular functions remain uncertain. We therefore investigated the effects of CS condensate (CSC) on in vitro wound closure of human gingival epithelial cells and their potential interactions with a major periodontal pathogen, Porphyromonas gingivalis. Low concentrations of CSC increased invasion of human gingival epithelial cells by P. gingivalis and induced changes in cytoskeleton and integrin expression, thereby modulating the cell migration.
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