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Development of plasma nano-bubbles with modified antibody for induction of apoptosis

Research Project

Project/Area Number 25630045
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Fluid engineering
Research InstitutionTohoku University

Principal Investigator

SATO Takehiko  東北大学, 流体科学研究所, 教授 (10302225)

Co-Investigator(Renkei-kenkyūsha) MIYAHARA Takashi  静岡大学, 工学研究科, 教授 (70239432)
OHTANI Kiyonobu  東北大学, 流体科学研究所, 助教 (80536748)
YOSHINO Daisuke  東北大学, 流体科学研究所, 助教 (80624816)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsバイオ流体力学 / プラズマナノバブル
Outline of Final Research Achievements

The underwater discharge device which produces a large amount of microscopic bubbles was accomplished by installing the insulation-coated needle-like and ring-shaped platinum wire electrodes in the ultrapure water and applying the high voltage to the needle electrodes. It has been shown that these bubbles generated a particle size distribution with a greatest frequency of particle size of 100 - 200 nm. Also, a verification method for ultrafine bubbles that was impossible for solid-gas determination was developed by developing the devices that pressurizes and observes the bubbles with a maximum of 100 atm in order to distinguish solid impurities such as electrode materials and the ultrafine bubbles, and that observes bubble deformation using shock waves. By these results, we proposed an important fundamental technology toward modification of antibodies of nano-bubbles.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2014 Other

All Presentation (5 results)

  • [Presentation] 水中衝撃波を用いたマイクロジェット生成法2014

    • Author(s)
      南共哉, 佐藤岳彦, 中嶋智樹, 吉野大輔, 金子俊郎
    • Organizer
      日本機械学会第92期流体工学部門講演会
    • Place of Presentation
      富山大学五福キャンパス(富山県富山市)
    • Year and Date
      2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Visualization of the Formation of Shock Waves at the Collapse of a Laser-induced Bubble2014

    • Author(s)
      Marc Tinguely, Takehiko Sato, Kiyonobu Ohtani and Mohamed Farhat
    • Organizer
      14th International Symposium on Advanced Fluid Information (AFI2014)
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2014-10-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of New Visualization Method for Plasma-Generated Nano-Micro Bubbles2014

    • Author(s)
      Takehiko Sato, Yuki Yamaguchi, Kiyonobu Ohtani, Takashi Miyahara and Tatsuyuki Nakatani
    • Organizer
      14th International Symposium on Advanced Fluid Information (AFI2014)
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2014-10-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Formation of Microjet by Plasma Generated Underwater Shock Wave2014

    • Author(s)
      Tomoya Minami, Takehiko Sato, Tomoki Nakajima, Daisuke Yoshino and Toshiro Kaneko
    • Organizer
      11th International Conference on Flow Dynamics (ICFD2014)
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2014-10-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of Plasma-generated Bubbles by Electron Microscope

    • Author(s)
      Takehiko Sato, Takashi Miyahara and Tatsuyuki Nakatani
    • Organizer
      13th International Symposium on Advanced Fluid Information
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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