Virus resistance induced by Wolbachia
| Project/Area Number |
25660262
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Insect science
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| Research Institution | Tohoku University |
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Principal Investigator |
Ote Manabu 東北大学, 生命科学研究科, 研究支援者 (20386717)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ボルバキア / ショウジョウバエ / ウイルス / RNA / 共生 |
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| Outline of Final Research Achievements |
Based on the Serbus's report, I elucidated the possible involvement of RNA-binding proteins in the Wolbachia-induced phenomenon. It was revealed that Drosophila mutants of RNA-binding proteins phenocopy the host resistance to RNA viruses induced by Wolbachia. The RNA-binding proteins were colocalized with Wolbachia in somatic cells, implying the direct interaction of Wolbachia and the RNA-binding proteins. These findings raise the possibility that Wolbachia target the RNA-binding proteins for manipulation of host biology.
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Report
(4 results)
Research Products
(1 results)
