| Project/Area Number |
25670487
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | National Center for Child Health and Development |
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Principal Investigator |
Nakamura Kyoko 国立研究開発法人国立成育医療研究センター, 細胞医療研究部, 研究員 (30124481)
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| Co-Investigator(Kenkyū-buntansha) |
Umezawa Akihiro 国立研究開発法人国立成育医療研究センター, 再生医療センター, 副所長/再生医療センター長 (70213486)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 糖鎖 / 細胞老化 / 発達小児科学 / 糖鎖マーカー / 幹細胞の老化 / 細胞表面糖鎖 / 幹細胞 / 糖脂質 |
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| Outline of Final Research Achievements |
Human somatic stem cells have been focused in addition to iPS cells and ES cells as a source of cell therapy products. However, somatic cells have a limited cell life span. It remains unclarified whether their properties of the somatic cells may alter during cellular ageing in culture. In this study, we investigated carbohydrate structures of human somatic cells during cellular ageing. Structures of glycoproteins and glycolipids dynamically changed in differentiation, proliferation, and ageing.
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