Application of boron carbide particles to boron neutron capture therapy

• Project/Area Number: 25670857
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Osaka University
• Principal Investigator: YURA YOSHIAKI 大阪大学, 歯学研究科(研究院), 教授 (00136277)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 口腔扁平上皮癌 / 中性子 / ホウ素化合物 / 炭化ホウ素球 / 超音波照射 / 溶媒 / 可溶化溶媒 / 水溶性ポリマー / 炭化ホウ素 / ホウ素中性子捕捉療法 / 炭化ホウ素粒

Outline of Final Research Achievements

Boronophenylalanine (BPA)is a major boron compound used in boron neutron capture therapy (BNCT)for cancer patients. Boron-rich boron carbide (B4C) nanoparticles are novel compounds containing a large number of born molecules. The tumor volume was smaller in B4C-mediated BNCT group than in neutron group. Purebright MB was found to solubilize B4C particles. This suggests that B4C particles injected intratumorally act as boron compounds for BNCT.

Research Products

• [Journal Article] Enhancing effect of ultrasound on boron concentrations in an oral squamous cell carcinoma cell line SAS for boron neutron capture therapy (2015)
  • Author(s): Yamamoto N, et al.
  • Journal Title: J Oral Maxillofac Surg Med Pathol Volume: 27 Pages: 487-492
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Enhancing effect of ultrasound on boron concentrations in an oral squamous cell carcinoma cell line SAS for boron neutron capture therapy (2015)
  • Author(s): Yamamoto N, et al.
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Volume: xx
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Boron carbide particle as a boron compound for boron neutron capture therapy (2014)
  • Author(s): Iwagami T et al.
  • Journal Title: Journal of Nuclear Medicine and Radiation Therapy Volume: 5 Issue: 02 Pages: 2-2
  • DOI: 10.4172/2155-9619.1000177
  • Peer Reviewed / Open Access
• [Journal Article] 新規のホウ素化合物を用いたホウ素中性子捕捉療法に対するソノポレーションの効果 (2014)
  • Author(s): 岩上隆紀、他
  • Journal Title: 口腔組織培養学会誌. Volume: 23 Pages: 144-145
• [Journal Article] Combinational effect of a geranylgeranyltransferase-I inhibitor and PKC inhibitor on human oral squamous cell carcinoma (2014)
  • Author(s): Hamada M, Miki T, Wakabayashi K, Iwai S, Yonekawa A, Yura Y
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Volume: -
  • Peer Reviewed
• [Journal Article] Sonoporation as an enhancing method for boron neutron capture therapy for squamous cell carcinomas (2013)
  • Author(s): Yamamoto N, Iwagami T, Kato I, Masunaga S, et. Al. 計9名
  • Journal Title: Radiat Oncol Volume: 8 Issue: 1 Pages: 280-280
  • DOI: 10.1186/1748-717x-8-280
  • Peer Reviewed / Open Access
• [Journal Article] .Enhancement of systemic tumor immunity for squamous cell carcinoma cells by an oncolytic herpes simplex virus (2013)
  • Author(s): Meshii N, et al
  • Journal Title: Cancer Gene Therapy Volume: 20 Issue: 9 Pages: 493-498
  • DOI: 10.1038/cgt.2013.45
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] ホウ素中性子捕捉におけるホウ素化合物としての炭化ホウ素粒の検討。 (2015)
  • Author(s): 多田晋也、他
  • Organizer: 第39回日本頭頚部癌学会・第4回アジア頭頚部癌学会合同大会
  • Place of Presentation: 神戸国際会議場（兵庫県・神戸市）
  • Year and Date: 2015-06-03
  • Int'l Joint Research
• [Presentation] ホウ素中性子捕捉療法(BNCT)における組織注入型ホウ素化合物B4C粒の溶解性に関する検討 (2015)
  • Author(s): 多田晋也、他
  • Organizer: 第69回日本口腔科学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府・大阪市）
  • Year and Date: 2015-05-13
• [Presentation] 組織注入型ホウ素化合物B4C粒の溶解性に関する検討 (2014)
  • Author(s): 多田晋也、他
  • Organizer: 平成26年度京都大学原子炉実験所専門研究会
  • Place of Presentation: 大阪府熊取町
  • Year and Date: 2014-09-29 – 2014-09-30
• [Presentation] ホウ素中性子捕捉療法によるヒト口腔扁平上皮癌の細胞死形態に関する検討 (2014)
  • Author(s): 由良義明、他
  • Organizer: 第11回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 吹田市
  • Year and Date: 2014-07-05 – 2015-07-06
• [Presentation] 炭化ホウ素粒のホウ素中性子捕捉療法への応用 (2014)
  • Author(s): 岩上隆紀、他
  • Organizer: 第11回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 吹田市
  • Year and Date: 2014-07-05 – 2014-07-06
• [Presentation] ホウ素中性子捕捉療法に対する炭化ホウ素粒の応用に関する研究 (2014)
  • Author(s): 岩上隆紀、他
  • Organizer: 第38回日本頭頸部癌学会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-12 – 2014-06-13
• [Presentation] ホウ素中性子捕捉療法が著効した舌癌頸部再発の1例 (2013)
  • Author(s): 鳴瀬智史、柳本惣市、山田慎一、川崎五郎、梅田正博、加藤逸郎、由良義明、大前政利
  • Organizer: 第67回日本口腔科学会学会学術集会
  • Place of Presentation: 栃木県総合文化センター(宇都宮市)
• [Presentation] ホウ素中性子捕捉療法に用いるホウ素化合物としての炭化ホウ素粒 (2013)
  • Author(s): 岩上隆紀、奥長秀介、山本直典、岩井聡一、加藤逸郎、中澤光博、由良義明
  • Organizer: 第67回日本口腔科学会学会学術集会
  • Place of Presentation: 栃木県総合文化センター(宇都宮市)
• [Presentation] 炭化ホウ素粒を用いたホウ素中性子捕捉療法に対するソノポレーションの効果 (2013)
  • Author(s): 岩上隆紀、山本直典、加藤逸郎、奥長秀介、竹下彰範、岩井聡一、中澤光博、由良義明
  • Organizer: 第58回日本口腔外科学会総会・学術集会
  • Place of Presentation: 福岡国際会議場（福岡市）
• [Presentation] Boron neutron capture therapy for recurrent head and neck malignancies without other treatment options.
  • Author(s): Kato I, Yamamoto N, Fujita Y, Ohmae M, Sakurai Y, Kumada H, Murata I, Miyamaru H, Maruhashi A, Kirihata M, Imahori Y, Suzuki M, Sumi T, Iwai S, Nakazawa M, Yura Y, Ono K
  • Organizer: 6th Trilateral Meeting on BNCT Meeting between Taiwan and Japan
  • Place of Presentation: Taipei Veterans General Hospital (Taiwan)
  • Invited
• [Remarks] 大阪大学歯学研究科口腔外科学第二教室
  • URL: http://web.dent.osaka-u.ac.jp/~surg2/research.html