Development of New Transition Metal Catalyst Based on Host-Guest Chemistry Using O/W Emulsion Method
Project/Area Number |
25810066
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Synthetic chemistry
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Research Institution | Osaka Dental University |
Principal Investigator |
TSUDA SUSUMU 大阪歯科大学, 歯学部, 助教 (50581021)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | シクロデキストリン / 遷移金属触媒 |
Outline of Final Research Achievements |
We developed a new family of imidazolium salts (L1-L9) bearing a CD (α-, β- and γ-CD) as precursors of N-heterocyclic carbene (NHC) ligands for asymmetric rhodiumcatalyzed 1,2-addition of arylboronic acids to aldehydes. The arylation of aldehydes has been successfully achieved by using L1, L2, and L5, but gave the corresponding diarylmethanols with only low ee values. The ee values were remarkably enhanced by L4, L7 and L8 to 80% ee, 94% ee and 83% ee, respectively. Secondly, we synthesized CD-linked Cyclopentadienes (L10-L12) as Cp ligand precursors by reacting permethylated cyclodextrin monotosylates with cyclopentadienyl lithium in the presence of lithium iodide. Cp-rhodium complexes was also synthesized from the precursors with Rh(COD)complex in the presence of sodium carbonate. We applied these Rh complexes for the asymmetric oxidative cycloaddition of benzamides and alkenes. The enantiomeric excess of the product were around 10% ee.
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Report
(3 results)
Research Products
(4 results)