Antitumor effect of the selective cyclooxygenase-2 inhibitor on bone and soft tissue sarcomas.

• Project/Area Number: 25861331
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Fukushima Medical University
• Principal Investigator: HAKOZAKI Michiyuki 福島県立医科大学, 医学部, 准教授 (10583651)
• Co-Investigator(Renkei-kenkyūsha): HOJO Hiroshi 福島県立医科大学, 会津医療センター, 教授 (90209213) ; ABE Masafumi 福島県立医科大学, 副学長 (00045783) ; KONNO Shinichi 福島県立医科大学, 医学部, 教授 (70254018) ; KIKUCHI Shinichi 福島県立医科大学, 学長 (80045773)
• Research Collaborator: TAJINO Takahiro 福島県立医科大学, 医学部, 客員教授 ; YAMADA Hitoshi 福島県立医科大学, 医学部, 講師 ; TAMURA Hirosumi 福島県立医科大学, 医療-産業トランスレーショナルリサーチセンター, 助教 ; YANAGISAWA Michiro 弘前大学, 医学部 ; NISHIDA Jun 東京医科大学, 医学部 ; NAGASAWA Hiroyuki 秋田大学, 医学部 ; TSUCHIYA Takashi 山形大学, 医学部 ; OGOSE Akira 新潟大学, 医歯学総合病院
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 骨軟部肉腫 / 悪性骨軟部腫瘍 / 分子標的治療 / 腫瘍細胞株 / 選択的シクロオキシゲナーゼ-2阻害薬 / 選択的シクロオキシゲナーゼ阻害薬

Outline of Final Research Achievements

The purpose of this study was to investigate a potential therapeutic role of ｃyclooxygenase-2 (COX-2) in bone and soft-tissue sarcomas.
In malignant peripheral nerve sheath tumor (MPNST), a rare and aggressive soft tissue sarcoma, overexpression of COX-2 was observed in 65.9%, was significantly associated with a poor overall survival, and was considered an independent risk factor for a poor outcome by the results of both univariate and multivariate analysis. Moreover, the selective COX-2 inhibitor etodolac induced apoptosis of MPNST cells through the activation of caspase-8, -9, and -3.
Selective COX-2 inhibitors including etodolac had an antitumor effect on MPNST cells, and their use holds promise as a novel therapeutic strategy for patients with MPNST to improve their prognoses.

Research Products

• [Journal Article] Overexpression of cyclooxygenase-2 in malignant peripheral nerve sheath tumor and selective cyclooxygenase-2 inhibitor-induced apoptosis by activating caspases in vitro. (2014)
  • Author(s): Hakozaki M, Tajino T, Yamada H, Kikuchi S, Yanagisawa M, Nishida J, Nagasawa H, Tsuchiya T, Ogose A, Konno S, Abe M, Hojo H
  • Journal Title: PLoS One Volume: 9 Issue: 2 Pages: e88035-e88035
  • DOI: 10.1371/journal.pone.0088035
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 軟部明細胞肉腫由来細胞株FCCS-1の樹立とその性状の解析. (2014)
  • Author(s): 箱崎道之, 夛村博澄, 田地野崇宏, 山田仁, 土橋悠, 加藤弘毅, 江崎淳二, 片平清昭, 渡辺慎哉, 和栗聡, 紺野愼一
  • Organizer: 第47回日本整形外科学会骨・軟部腫瘍学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2014-07-17
• [Presentation] 軟部明細胞肉腫由来細胞株FCCS-1の樹立とその性状の解析 (2014)
  • Author(s): 箱﨑道之, 多村博澄, 田地野崇宏, 山田仁, 土橋悠, 加藤弘毅, 江崎淳二, 片平清昭, 渡辺慎哉, 和栗聡, 紺野愼一
  • Organizer: 第47回日本整形外科学会骨・軟部腫瘍学術集会
  • Place of Presentation: 大阪市