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The attempt to establish new cerebroprotection laws against septic encephalopathy

Research Project

Project/Area Number 25861401
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionTokyo Medical University

Principal Investigator

Miyashita Ryoichi  東京医科大学, 医学部, 助教 (30649281)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsミトコンドリア / 鎮静薬 / 敗血症性脳症 / プロポフォール / デクスメデトミジン / 呼吸鎖 / 麻酔薬 / 脳内ミトコンドリア / Ca代謝 / 麻酔薬の影響
Outline of Final Research Achievements

We acknowledged that propofol affected the induced increase in the permeability of mitochondrial membrane and the respiration chain by its dosage. The possibility that might induce the cell death of mitochondria and the cessation of respiration chain was suggested. In comparison to it, we did not acknowledge that sevoflurane, midazolam and dexmedetomidine affected it in spite of their dosages. In addition, propofol, sevoflurane, and midazolam suppressed the ability which mitochondria took in calcium. On the other hand, we did not acknowledge that dexmedetomidine affected it. We aimed at analyzing the pathologic condition of septic encephalopathy from the viewpoint of mitochondria but the research findings led to the concerned conclusion that various tranquilizers affected the brain mitochondrial functions as the first stage of analysis in the mechanism of septic encephalopathy which tranquilizers developed delirium.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 Other

All Presentation (4 results) Book (4 results)

  • [Presentation] 高用量プロポフォールはミトコンドリア呼吸鎖を抑制する2015

    • Author(s)
      坂本美紀 宮下亮一 沖田綾乃 平林清子 今泉均 内野博之
    • Organizer
      第62回日本麻酔科学会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 敗血症の初期輸液療法 フレッシュマンズコース(モーニングレクチャー)2015

    • Author(s)
      宮下亮一
    • Organizer
      第42回日本集中治療医学会学術集会
    • Place of Presentation
      ホテル日航東京
    • Year and Date
      2015-02-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 麻酔薬における脳保護機序解明への現状と展望

    • Author(s)
      宮下亮一
    • Organizer
      第60回日本麻酔科学会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2013 Research-status Report
  • [Presentation] 鎮静薬が及ぼす脳内酸素代謝及びCa代謝への影響

    • Author(s)
      宮下亮一
    • Organizer
      第41回日本集中治療医学会
    • Place of Presentation
      京都国際会議場(京都)
    • Related Report
      2013 Research-status Report
  • [Book] Neuroanesthesia and Cerebrospinal Protection2015

    • Author(s)
      Ryoichi Miyashita
    • Total Pages
      725
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] 麻酔科学 文献レビュー 2015-20162015

    • Author(s)
      宮下亮一 内野博之
    • Total Pages
      239
    • Publisher
      秀潤社
    • Related Report
      2015 Annual Research Report
  • [Book] 救急医学 Sepsis 最新知見と治療戦略2015

    • Author(s)
      今泉均 宮下亮一
    • Total Pages
      272
    • Publisher
      へるす出版
    • Related Report
      2014 Research-status Report
  • [Book] 神経麻酔Q&A -エビデンスに基づく最新の知識とテクニック-2014

    • Author(s)
      宮下亮一
    • Total Pages
      278
    • Publisher
      総合医学社
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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