Iron status and cytokine profile in pulmonary MAC disease

• Project/Area Number: 26461157
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Niigata University
• Principal Investigator: Moro Hiroshi 新潟大学, 医歯学総合病院, 助教 (40509452)
• Co-Investigator(Kenkyū-buntansha): 高田 俊範 新潟大学, 医歯学総合病院, 特任教授 (40361919)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肺MAC症 / 鉄 / Hepcidin / 鉄代謝 / IP-10

Outline of Final Research Achievements

Patients with fibrocavitary MAC lung disease tend to have elevated inflammatory markers, poor nutritional status and deterioration of iron status, and long-term management is necessary. Serum IP-10 levels were significantly increased in the cavitary form, and it is significantly correlated with CRP, Fe, pre-Alb. With prolonged pro-inflammatory state of pulmonary MAC disease, IP-10 might associated with comorbid poor nutritional status and deterioration of iron status, and it might reflect the disease forms and severity of pulmonary MAC disease, as well as pulmonary tuberculosis.

Research Products

• [Presentation] 鉄代謝からみた感染症～診断、治療への応用に向けて (2016)
  • Author(s): 茂呂寛
  • Organizer: 第65回日本感染症学会東日本地方学術集会
  • Place of Presentation: 朱鷺メッセ（新潟県新潟市）
  • Year and Date: 2016-10-26
  • Invited
• [Presentation] Comparison of cytokine profile, nutrition and iron status in two forms of pulmonary MAC disease (2015)
  • Author(s): 茂呂 寛
  • Organizer: IDWeek2015
  • Place of Presentation: サンディエゴ（米国）
  • Year and Date: 2015-10-07
  • Int'l Joint Research