EMT inhibitor for the treatment of idiopathic pulmonary fibrosis
| Project/Area Number |
26461200
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高橋 和久 順天堂大学, 医学部, 教授 (80245711)
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| Co-Investigator(Renkei-kenkyūsha) |
SAYA Hideyuki 慶応大学, 医学部, 教授 (80264282)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 特発性肺線維症 / 上皮間葉転換 / 肺胞上皮 / 肺線維症マウスモデル / ブレオマイシン |
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| Outline of Final Research Achievements |
It has been reported that transforming growth factor (TGF) β-mediated epithelial-mesenchymal transition (EMT) of alveolar epithelial cells contributes to the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, no agents which can target EMT have not been developed for the treatment of IPF. Here, we established the in vitro models of EMT of alveolar epithelial cells suitable for high-throughput screening of antifibrotic agents for IPF. We found that drug candidate has inhibitory effect on TGF-β-mediated EMT of alveolar epithelial cells in vitro. We also have tested this drug for antifibrotic effect in murine pulmonary fibrosis model induced by bleomycin injection, and found that this drug has antifibrotic activity in vivo. These data suggest that EMT inhibitor may be promising and novel anti-fibrotic agent for the prevention of IPF.
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Report
(5 results)
Research Products
(21 results)
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[Journal Article] Chemotherapy induced microRNA-125/HER2 pathway as a novel therapeutic target for trastuzumab-mediated cellular cytotoxicity in small-cell lung cancer.2015
Author(s)
Yagishita S, Fujita Y, Kitazono S, Nakadate Y, Sawada T, Kitamura Y, Shimoyama T, Takahashi F, Takahashi K, Tamura T, Koizumi F.
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Journal Title
Mol Cancer Ther
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Treatment with insulin-like growth factor 1 receptor inhibitor reverses hypoxia-induced epithelial-mesenchymal transition in non-small cell lung cancer2014
Author(s)
Nurwidya F, Takahashi F, Kobayashi I, Murakami A, Kato M, Minakata K, Nara T, Hashimoto M, Yagishita S, Baskoro H, Hidayat M, Shimada N, Takahashi K.
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Journal Title
Biochem Biophys Res Commun
Volume: 455
Issue: 3-4
Pages: 332-338
DOI
Related Report
Peer Reviewed
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[Journal Article] Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor2013
Author(s)
Murakami A, Takahashi F, Nurwidya F, Kobayashi I, Minakata K, Hashimoto M, Nara T, Kato M, Tajima K, Shimada N, Iwakami S, Moriyama M, Moriyama H, Koizumi F, Takahashi K
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Journal Title
PLoS One
Volume: 9(1)
Issue: 1
Pages: e86459-e86459
DOI
Related Report
Peer Reviewed
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[Presentation] Translational Evidence of Zinc finger E-box binding homeoprotein 1 Involvement in Acquired Resistance to Gefitinib in Non-small Cell Lung Cancer2014
Author(s)
Nurwidya F, Takahashi F, Kobayashi I, Shimada N, Murakami A, Baskoro H, Suina K, Kanemaru R, Yagishita S, Asao T, Ohashi R, Muraki K, Yoshioka Y, Takahashi M, Sasaki S, Takahashi K.
Organizer
Congress of the Asian Pacific Society of Respirology (APSR)
Place of Presentation
Bali, Indonesia
Year and Date
2014-11-13 – 2014-11-16
Related Report
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[Presentation] Oct4 plays a key role in the persistence of gefitinib-resistant lung cancer stem cells.2014
Author(s)
Kobayashi I, Takahashi F, Nurwidya F, Murakami A, Kato M, Shimada N, Suina K, Kanemaru R, Yagishita S, Ko R, Asao T, Ohashi R, Muraki K, Yoshioka Y, Takahashi M, Takahashi K.
Organizer
Congress of the Asian Pacific Society of Respirology (APSR)
Place of Presentation
Bali, Indonesia
Year and Date
2014-11-13 – 2014-11-16
Related Report
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[Presentation] Epithelial-mesenchymal transition-driven gefitinib resistance in non-small cell lung cancer is mediated by zinc-finger E-box protein 1.2014
Author(s)
Nurwidya F, Takahashi F, Murakami A, Kobayashi I, Kato M, Minakata K, Yagishita S, Koyama R, Muraki K, Takahashi M, Shimada N, Takahashi K.
Organizer
Congress of American Thoracic Society (ATS)
Place of Presentation
San Diego, USA
Year and Date
2014-05-16 – 2014-05-21
Related Report
