| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We measured the bone morphology in Lect 2 knockout mice and found that the bone mass decreased as compared with the wild type mouse. Examination of bone metabolism markers in serum showed an increase in osteoclast activation marker TRAP 5b in Lect 2 KO mice. Even at the cellular level, osteoclasts were found to inhibit the differentiation of macrophages into mature osteoclasts by addition of Lect 2. In osteoblasts, there was no significant effect on the differentiation stage. However, in the postmenopausal osteoporosis model from which the ovaries were removed, there was no difference in the extent of bone loss in wild type and Lect 2 KO mice.
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