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Pathogenesis of insufficient adrenocortical response in premature sheep fetus

Research Project

Project/Area Number 26461627
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionTohoku University

Principal Investigator

Kitanishi Ryuta  東北大学, 大学病院, 助手 (20436116)

Co-Investigator(Kenkyū-buntansha) 齋藤 昌利  東北大学, 大学病院, 講師 (00451584)
埴田 卓志  東北大学, 大学病院, 助手 (30400360)
松田 直  東北大学, 大学病院, 准教授 (50361100)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords胎児 / 早産児 / 子宮内炎症 / 副腎皮質ホルモン / CRH負荷試験 / ヒツジ / 胎仔 / ACTH / cortisol / cortisone / 人工胎盤 / 虚血 / 炎症 / コーチゾル分泌能 / ポンプレス人工胎盤システム / ヒツジ胎仔
Outline of Final Research Achievements

We made a plan to clarify the effect of intrauterine inflammation on the cortisol secretion and its circulatory response in premature lamb because the fetal endocrine potential to adapt the postnatal environment might have been already deteriorated by the inflammatory stress before birth. In this study, we separated sheep fetuses into two groups: control group (n=6) and inflammation group (n=6), and we could store the plasma samples for 31 times of the corticotrophin releasing hormone (CRH) test. In consequence, we could measured the concentrations of ACTH, cortisol, cortisone, Aldosterone and Dehydroepiandrosterone sulfate (DHEA-S) by the method of steroid profiling analysis using the LC-MS/MS. In the inflammation group than the control, production of cortisol was promoted during the CRH test. These findings suggest the intrauterine inflammation stress might induce the development of transitional zones where 3β-hydroxysteroid dehydrogenase is expressed.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Cerebral Ischemia or Intrauterine Inflammation Promotes Differentiation of Oligodendroglial Precursors in Preterm Ovine Fetuses: Possible Cellular Basis for White Matter Injury2014

    • Author(s)
      Kitanishi R, Matsuda T, Watanabe S, Saito M, Hanita T, Watanabe T, Kobayashi Y.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 234 Issue: 4 Pages: 299-307

    • DOI

      10.1620/tjem.234.299

    • NAID

      130004704767

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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