Preventative agents in mouse preterm birth models induced by bacterial virulence factors.

• Project/Area Number: 26461652
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Research Institute, Osaka Medical Center for Maternal and Child Health
• Principal Investigator: YANAGIHARA Itaru 地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), 免疫部門, 部長 (60314415)
• Co-Investigator(Kenkyū-buntansha): 北島 博之 地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), その他部局等, 新生児科主任部長 (10501041) ; 光田 信明 地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), その他部局等, 診療局長(兼産科主任部長) (50209805)
• Research Collaborator: MIMURA Kazuya ; KAWAI Yasuhiro ; NISHIUMI Fumiko ; NAKAHIRA Kumiko ; WU Heng Ning ; NAKURA Yukiko ; NAMBA Fumihiko ; UCHIDA Kaoru ; SAKA Ryuta ; WAKIMOTO Tetsu ; MEHANDJIEV R Tzvetozar
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: ウレアプラズマ / LPS / 水酸化フラーレン / チオレドキシン１ / 感染性流早産 / 早産 / 抗酸化 / 抗炎症 / 高感度細菌RNA同定

Outline of Final Research Achievements

Intrauterine infection such as by Escherichia coli and Ureaplasma spp. induce placental inflammation and are one of the leading causes of preterm birth. We investigated the preventative effect of hydroxylated fullerene in a mouse preterm birth model induced by ureaplasmal TLR-2 ligand, UPM-1. The preterm birth rate decreased from 72.7% to 18.2% after an injection with hydroxylated fullerene in mice.
The preventative effect of thioredoxin-1 was also investigated in Escherichia coli lipopolysaccharide induced preterm birth mouse model. Recombinant human thoredoxin-1 prevented the rise of systemic proinflammatory cytokine levels in dam mice. After LPS challenge, placentas exhibited severe maternal vascular dilatation and congestion and a marked decidual neutrophil activation. These placental pathological findings were ameliorated by recombinant human thioredoxin-1, and the rate of inflammation-induced preterm delivery was attenuated.

Research Products

• [Int'l Joint Research] フィリピン大学マニラ校(フィリピン)
• [Journal Article] High sensitive one-step RT-PCR using MMLV reverse transcriptase, DNA polymerase with reverse transcriptase activity,and DNA/RNA helicase. (2017)
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  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 印刷中 Issue: 1 Pages: 128-133
  • DOI: 10.1016/j.bbrc.2017.04.030
  • Peer Reviewed
• [Journal Article] Intracellular fate of Ureaplasma parvum entrapped by host cellular autophagy (2017)
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  • Journal Title: MicrobiologyOpen Volume: - Issue: 3 Pages: 1-15
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  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Enhanced detection of RNA by MMLV reverse transcriptase coupled with thermostable DNA polymerase and DNA/RNA helicase. (2017)
  • Author(s): Okano,H., Katano,Y., Baba,M., Fujiwara,A., Hidese,R., Fujiwara,S., Yanagihara,I., Hayashi,T., Kojima,K., Yasukawa,K.
  • Journal Title: Enzyme Microb.Technol. Volume: 96 Pages: 111-120
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  • Peer Reviewed
• [Journal Article] Amorphous nanosilica particles evoke vascular relaxation through PI3K/Akt/eNOS signaling. (2016)
  • Author(s): Onodera A, Yayama K, Tanaka A, Morosawa H, Furuta T, Takeda N, Kakiguchi K, Yonemura S, Yanagihara I, Tsutsumi Y, Kawai Y.
  • Journal Title: Fundam Clin Pharmacol. Volume: 30 Issue: 5 Pages: 433-439
  • DOI: 10.1111/fcp.12206
  • Peer Reviewed
• [Journal Article] Human thioredoxin-1 attenuates the rate of lipopolysaccharide-induced preterm delivery in mice in association with its anti-inflammatory effect. (2016)
  • Author(s): Namba F, Kobayashi-Miura M, Goda T, Nakura Y, Nishiumi F, Son A, Kubota A, Yodoi J, Yanagihara I.
  • Journal Title: Pediatr Res. Volume: 80 Issue: 3 Pages: 433-439
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sudden infant death due to Lactococcal infective endocarditis. (2016)
  • Author(s): Taniguchi K, Nakayama M, Nakahira K, Nakura Y, Kanagawa N, Yanagihara I, Miyaishi S
  • Journal Title: Legal Medicine Volume: Vol.19 Pages: 107-111
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  • Peer Reviewed
• [Journal Article] Lethal hypophosphatasia successfully treated with enzyme replacement from day 1 after birth. (2016)
  • Author(s): Okazaki Y, Kitajima H, Mochizuki N, Kitaoka T, Michigami T, Ozono K.
  • Journal Title: Eur J Pediatr. Volume: 175 Pages: 433-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] TUBA1A mutation can cause a hydranencephaly-likesevere form of cortical dysgenesis. (2015)
  • Author(s): Yokoi S, Ishihara N, Miya F, Tsutsumi M, Yanagihara I, Fujita N, Yamamoto H, Kato M, Okamoto N, Tsunoda T, Yamasaki M, Kanemura Y, Kosaki K, Kojima S, Saitoh S, Kurahashi H, Natsume J.
  • Journal Title: Sci Rep. Volume: 23 Issue: 1 Pages: 1-10
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  • Peer Reviewed / Open Access
• [Journal Article] Hydroxylated fullerene: a potential antiinflammatory and antioxidant agent for preventing mouse preterm birth. (2015)
  • Author(s): Wakimoto T, Uchida K, Mimura K, Kanagawa T, Mehandjiev TR, Aoshima H, Kokubo K, Mitsuda N, Yoshioka Y, Tsutsumi Y, Kimura T, Yanagihara I.
  • Journal Title: Am J Obstet Gynecol. Volume: 213
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] In vitro activity of five quinolones and analysis of the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum clinical isolates from perinatal patients in Japan. (2015)
  • Author(s): Kawai Y, Nakura Y, Wakimoto T, Nomiyama M, Tokuda T, Takayanagi T, Shiraishi J, Wasada K, Kitajima H, Fujita T, Nakayama M, Mitsuda N, Nakanishi I, Takeuchi M, Yanagihara I.
  • Journal Title: Antimicrob Agents Chemother. Volume: 59 Issue: 4 Pages: 2358-2364
  • DOI: 10.1128/aac.04262-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Immunolocalization of surfactant protein D in the liver from infants with cholestatic liver disease. (2015)
  • Author(s): Saka R, Yanagihara I, Sasaki T, Nose S, Takeuchi M, Nakayama M, Okuyama H.
  • Journal Title: J Pediatr Surg. Volume: 50 Pages: 297-300
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ウレアプラズマの脅威～過剰な免疫反応が流早産を引き起こす～ (2015)
  • Author(s): 名倉由起子、柳原格
  • Journal Title: 大阪府立母子保健総合医療センター雑誌 Volume: 31 Pages: 1-6
  • Peer Reviewed / Open Access
• [Journal Article] Perinatal factors associated with long-term respiratory sequelae in extremely low birthweight infants. (2015)
  • Author(s): Hirata, K., Nishihara, M., Shiraishi, J., Hirano, S., Matsunami, K., Sumi, K., Wada, N., Kawamoto, Y., Nishikawa, M., Nakayama, M., Kanazawa, T., Kitajima, H., & Fujimura, M.
  • Journal Title: Archives of Disease in Childhood: Fetal and Neonatal Edition. Volume: 0 Issue: 4 Pages: F314-F319
  • DOI: 10.1136/archdischild-2014-306931
  • Peer Reviewed / Open Access
• [Journal Article] Pathological examination of the placenta in small for gestational age (SGA)children with or without postnatal catch-up growth. (2015)
  • Author(s): Tachibana M, Nakayama M, Ida S, Kitajima H, Mitsuda N, Ozono K, Miyoshi Y.
  • Journal Title: J Matern Fetal Neonatal Med. Volume: 17 Issue: 6 Pages: 1-18
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Parental Nutrition-Associated Liver Disease in Extremely Low Birth Weight Infants with Intestinal Disease. (2015)
  • Author(s): Hirano K, Kubota A, Nakayama M, Kawahara H, Yoneda A, Tazuke Y, Tani G, Ishii T, Goda T, Umeda S, Hirno S, Shiraishi J, Kitajima H.
  • Journal Title: Pediatr Int. Volume: 57 Issue: 4 Pages: 677-81
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Long-term alpha-tocopherol supplements may improve mental development in extremely low birthweight infants. (2015)
  • Author(s): Kitajima H, Kanazawa T, Mori R, Hirano S, Ogihara T, Fujimura M.
  • Journal Title: Acta Paediatr. Volume: 104 Issue: 1 Pages: 82-9
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] In utero resolution of microcystic congenital cystic adenomatoid malformation after prenatal betamethasone therapy: A report of three cases and a literature review. (2015)
  • Author(s): Yamashita, A., Hidaka, N., Yamamoto, R., Nakayama, S., Sasahara, J., Ishii, K. and Mitsuda, N.
  • Journal Title: J Clin Ultrasound Volume: 43 Issue: 7 Pages: 451-7
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  • Open Access / Acknowledgement Compliant
• [Journal Article] Incidence and risk factors for recurrent spontaneous preterm birth: A retrospective cohort study in Japan. (2015)
  • Author(s): Yamashita, M., Hayashi, S., Endo, M., Okuno, K., Fukui, O., Mimura, K., Tachibana, Y., Ishii, K., Mitsuda, N. and Kimura, T.
  • Journal Title: J Obstet Gynaecol Res Volume: 41 Issue: 11 Pages: 1708-14
  • DOI: 10.1111/jog.12786
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Correlation between lung to thorax transverse area ratio and observed/expected lung area to head circumference ratio in fetuses with left-sided diaphragmatic hernia. (2015)
  • Author(s): Hidaka, N., Murata, M., Sasahara, J., Ishii, K. and Mitsuda, N.
  • Journal Title: Congenit Anom (Kyoto) Volume: 55 Issue: 2 Pages: 81-4
  • DOI: 10.1111/cga.12092
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Associated anomalies in congenital diaphragmatic hernia: perinatal characteristics and impact on postnatal survival. (2015)
  • Author(s): Hidaka, N., Ishii, K., Mabuchi, A., Yamashita, A., Ota, S., Sasahara, J., Murata, M. and Mitsuda, N.
  • Journal Title: J Perinat Med Volume: 43 Issue: 2 Pages: 245-52
  • DOI: 10.1515/jpm-2014-0110
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] [Bupivacaine-induced Anaphylaxis in a Parturient Undergoing Cesarean Section]. (2015)
  • Author(s): Iwasaki, M., Tachibana, K., Mitsuda, N. and Kinouchi, K.
  • Journal Title: Masui Volume: 64 Pages: 200-4
  • NAID: 40020346417
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Twin-Twin Transfusion Syndrome in Cases with Suspected Close Proximity of Umbilical Cord Insertions. (2015)
  • Author(s): Sato, Y., Ishii, K., Yonetani, N., Yamamoto, R. and Mitsuda, N.
  • Journal Title: Fetal Diagn Ther Volume: 20150808 Issue: 4 Pages: 1-4
  • DOI: 10.1159/000437366
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Significance of chorionicity on long-term outcome of low birthweight infants of <1500g in twin pregnancies. (2015)
  • Author(s): Kawamura, H., Ishii, K., Yonetani, N., Mabuchi, A., Hayashi, S. and Mitsuda, N.
  • Journal Title: J Obstet Gynaecol Res Volume: 41 Issue: 8 Pages: 1185-1192
  • DOI: 10.1111/jog.12703
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Significance of Velamentous Cord Insertion for Twin-Twin Transfusion Syndrome. (2015)
  • Author(s): Yonetani, N., Ishii, K., Kawamura, H., Mabuchi, A., Hayashi, S. and Mitsuda, N.
  • Journal Title: Fetal Diagn Ther Volume: 20150428 Issue: 4 Pages: 1-6
  • DOI: 10.1159/000381639
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prenatally diagnosed monochorionic diamniotic triplet pregnancy. (2015)
  • Author(s): Yonetani, N., Ishii, K., Mabuchi, A., Sasahara, J., Hayashi, S. and Mitsuda, N.
  • Journal Title: Obstet Gynaecol Res Volume: 41 Issue: 8 Pages: 1266-1268
  • DOI: 10.1111/jog.12688
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Postnatal outcome in cases of prenatally diagnosed fetal ovarian cysts under conservative prenatal management. (2015)
  • Author(s): Nakamura, M., Ishii, K., Murata, M., Sasahara, J. and Mitsuda, N.
  • Journal Title: Fetal Diagn Ther Volume: 37 Issue: 2 Pages: 129-134
  • DOI: 10.1159/000365146
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Monochorionic monozygotic twin pregnancy complicated with twin-twin transfusion syndrome presenting with an obvious lambda sign in the first trimester. (2015)
  • Author(s): Yamashita, A., Ishii, K., Hidaka, N., Yonetani, N., Hayashi, S., Takeuchi, M. and Mitsuda, N.
  • Journal Title: Fetal Diagn Ther Volume: 37 Issue: 2 Pages: 154-156
  • DOI: 10.1159/000367969
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 新生児期に先天性疾患に対する小児外科手術を受けた女性の妊娠と分娩. (2015)
  • Author(s): 浮田真吾, 林周作, 川口晴菜, 山本亮, 村田将春, 笹原淳, 日高庸博, 石井桂介, 光田信明.
  • Journal Title: 日本周産期・新生児医学会雑誌 Volume: 51 Pages: 1046-50
• [Journal Article] 【周産期救急の初期対応:そのポイントとピットフォール 産科編】 疾患:いかに的確に対応するか 分娩時に診断された癒着胎盤への対応のコツと落とし穴. (2015)
  • Author(s): 林周作, 光田信明
  • Journal Title: 周産期医学 Volume: 45 Pages: 806-9
• [Journal Article] 早産既往妊婦への早産予防ケア (2015)
  • Author(s): 林周作, 光田信明
  • Journal Title: 産婦人科の実際 Volume: 45 Pages: 823-8
  • NAID: 40020504709
• [Journal Article] 看護職が携帯型超音波診断装置を使用する有用性. (2015)
  • Author(s): 大嶌佳代, 稲盛陽子, 馬淵宙美, 北田真理, 塚田富美子, 宮川祐三子, 光田信明.
  • Journal Title: 大阪母性衛生学会雑誌 Volume: 51 Pages: 54-8
• [Journal Article] 染色体異常のある新生児と家族同室についての一考察 13・18トリソミーの症例を通して. (2015)
  • Author(s): 藪脇晴美, 石橋咲恵, 宇田川直子, 仙石海, 小川典子, 宮川祐三子, 光田信明.
  • Journal Title: 大阪母性衛生学会雑誌 Volume: 51 Pages: 66-8
• [Journal Article] Postpartum hemorrhageに対してBakriバルーンを使用した23症例の検討. (2015)
  • Author(s): 橘陽介, 遠藤誠之, 林周作, 味村和哉, 信永敏克, 光田信明, 木村正.
  • Journal Title: 日本周産期・新生児医学会雑誌 Volume: 51 Pages: 248-53
• [Journal Article] 【我々はこうしている-ガイドラインには対応が示されていない症例にどう対応するか?】 母体・胎児編 妊娠14週 甲状腺検査で異常値がでた. (2015)
  • Author(s): 田口貴子, 光田信明.
  • Journal Title: 周産期医学 Volume: 45 Pages: 277-9
• [Journal Article] 脊髄くも膜下麻酔後にアナフィラキシー反応を起こした予定帝王切開妊婦の1症例. (2015)
  • Author(s): 岩崎光生, 橘一也, 光田信明, 木内恵子.
  • Journal Title: 麻酔 Volume: 64 Pages: 200-4
  • NAID: 40020346417
• [Journal Article] Light for Date児として出生した極低出生体重児の幼児期低身長の頻度と予後因子. (2015)
  • Author(s): 田口貴子, 笹原淳, 林周作, 石井桂介, 光田信明.
  • Journal Title: 日本周産期・新生児医学会雑誌 Volume: 50 Pages: 1254-8
• [Journal Article] 成育医療の現状 体外受精から周産期医療に向けて 生殖医療を通して見た周産期医療の今後の課題 (2015)
  • Author(s): 光田信明
  • Journal Title: 日本病院会雑誌 Volume: 62 Pages: 70-89
• [Journal Article] 3D-CT検査を補完的に用いて出生前診断に至った希な胎児骨系統疾患 軟骨無発生症の1例. (2015)
  • Author(s): .笹原淳, 石井桂介, 村田将春, 林周作, 日高庸博, 岡本陽子, 光田信明
  • Journal Title: 日本周産期・新生児医学会雑誌 Volume: 50 Pages: 1336-40
• [Journal Article] Immunolocalization of surfactant protein D in the liver from infants with chkestatic liver disease (2015)
  • Author(s): Saka R, Yanagihara I, Sasaki T, Nose S, Takeuchi M, Nakayama M, Okuyama H.
  • Journal Title: Journal of Pediatric Surgery Volume: 50 Issue: 2 Pages: 297-300
  • DOI: 10.1016/j.jpedsurg.2014.11.020
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Complete Genome Sequence of Ureaplasma parvum Serovar 3 Strain SV3F4, Isolated in Japan (2014)
  • Author(s): Wu HN, Nakura Y, Motooka D, Nakamura S, Nishiumi F, Ishino S, Kawai Y, Tanaka T, Takeuchi M, Nakayama M, Fujita T, Yanagihara I
  • Journal Title: Genome Announc Volume: 2(3) Issue: 3
  • DOI: 10.1128/genomea.00256-14
  • Peer Reviewed / Open Access
• [Journal Article] The expression of surfactant proteins A and D in the intestines and pancreas of murine fetuses (2014)
  • Author(s): Ryuta Saka, Hiroomi Okuyama, Kaoru Uchida, Kumiko Nakahira, Takashi Sasaki, Satoko Nose, Masahiro Nakayama, Masahiro Fukuzawa, Itaru Yanagihara
  • Journal Title: Open Journal of Pediatrics Volume: 4 Issue: 01 Pages: 12-20
  • DOI: 10.4236/ojped.2014.41002
  • Peer Reviewed / Open Access
• [Journal Article] 21世紀の科学でWilson-Mikity 症候群を再考する (2014)
  • Author(s): 柳原格、萩原亨
  • Journal Title: 日本未熟児新生児学会雑誌 Volume: 26 Pages: 244-247
  • Peer Reviewed
• [Presentation] 胸部圧迫にて、重度の空気寒栓をきたしたと思われる2例 (2016)
  • Author(s): 望月成隆、木村丈、小畑慶輔、今西洋介、祝原賢幸、野崎昌俊、谷口英俊、白石淳、平野慎也、柳原格、竹内真、北島博之
  • Organizer: 第61回日本新生児育成医学会
  • Place of Presentation: 大阪
  • Year and Date: 2016-12-01
• [Presentation] デジタルPCRの高感度化と臨床診断への応用」 (2016)
  • Author(s): 柳原格、名倉由起子、吉村芳修
  • Organizer: 第68回日本生物工学会大会
  • Place of Presentation: 富山
  • Year and Date: 2016-09-28
  • Invited
• [Presentation] Association between MTHFR C677T polymorphism with intervillous and decidual pathology in human cases with pregnancy loss (2016)
  • Author(s): Tzvetozar R Mehandjiev, Nodoka Tenno, Yukiko Nakura, Tetsu Wakimoto ,Kazuya Mimura ,Masahiro Nakayama, Takeshi Kanagawa, Takuji Tomimatsu, Tomio Fujita, Yoshihiro Onouchi, Makoto Takeuchi, Tadashi Kimura, Itaru Yanagihara
  • Organizer: The 32nd Annual Meeting of European Society of Human Reproduction and Embryology
  • Place of Presentation: Helsinki
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] U.parvum 感染とガレクチンの関係 (2016)
  • Author(s): 西海 史子、柳原 格
  • Organizer: 第43回日本マイコプラズマ学会
  • Place of Presentation: 長崎
  • Year and Date: 2016-06-24
• [Presentation] 死産あるいは早期新生児死亡肺炎例における肺組織メタゲノム解析 (2016)
  • Author(s): 名倉由起子、中山雅弘、竹内真、柳原格
  • Organizer: 第52回日本周産期・新生児医学会学術集会
  • Place of Presentation: 富山
  • Year and Date: 2016-06-16
• [Presentation] 過酸化水素によるVibrio vulnificusの溶菌 (2016)
  • Author(s): 吉村芳修、柳原格
  • Organizer: 第３６回近畿腸管微生物研究会総会
  • Place of Presentation: 大阪
  • Year and Date: 2016-06-09
  • Invited
• [Presentation] 早産におけるウレアプラズマの重要性とその病原発揮機構 (2016)
  • Author(s): 山本亮、柳原格
  • Organizer: 妊婦の感染と早産を考える会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 過酸化水素によるVibrio vulnificusの溶菌とsulfonyl fluoride化合物による促進 (2016)
  • Author(s): 吉村芳修、吉田眞一、柳原格
  • Organizer: 日米医学協力研究会コレラ・細菌性腸管感染症専門部会
  • Place of Presentation: 京都
• [Presentation] ナノマテリアルが胎盤関門の透過性に与える影響評価 (2015)
  • Author(s): 清水雄貴、吉岡靖雄、森下裕貴、難波佑貴、柳原 格、東阪和馬、長野一也、堤康央
  • Organizer: 第65回日本薬学会近畿支部、総会
  • Place of Presentation: 大阪
  • Year and Date: 2015-10-17
• [Presentation] Neutrophil depletion increase silica nanoparticle-induced placental cellular damage. (2015)
  • Author(s): Kazuma Higashisaka, Yuki Iwahara, Itaru Yanagihara, Shigeru Saito, Yasuo Yoshioka, Yasuo Tsutsumi.
  • Organizer: 51st Congress of the European Society of Toxicology.
  • Place of Presentation: Proto Portugal
  • Year and Date: 2015-09-13
  • Int'l Joint Research
• [Presentation] ナノマテリアルの胎盤関門透過性へ与える影響の評価 (2015)
  • Author(s): 清水雄貴、吉岡靖雄、森下裕貴、瀧村優也、難波佑貴、柳原格、東阪和馬、堤康央
  • Organizer: 第42回日本毒性学会、学術年会
  • Place of Presentation: 金沢
  • Year and Date: 2015-06-29
• [Presentation] Effect of nanomaterial on permeability of blood-placenta barrier. (2015)
  • Author(s): Yuki Shimizu, Yasuo Yoshioka, Yuki Morishita, Yuya Takimura, Yuki Namba, Shin-ichi Tsunoda, Itaru Yanagihara, Lazuma Higashisaka, Yasuo Tsutsumi.
  • Organizer: 7th International Congress Asian Society of Toxicology
  • Place of Presentation: Jeju, South Korea
  • Year and Date: 2015-06-23
  • Int'l Joint Research / Invited
• [Presentation] Depletion of neutrophil might exacerbate pregnancy complication induced by silica nanoparticles. (2015)
  • Author(s): Kasuma Higashisaka, Yuki Iwahara, Kota Tanaka, Itaru Yanagihara, Yasuo Yoshioka, Yasuo Tsutsumi.
  • Organizer: 7th International Congress Asian Society of Toxicology
  • Place of Presentation: Jeju, South Korea
  • Year and Date: 2015-06-23
  • Int'l Joint Research / Invited
• [Presentation] ウレアプラズマのキノロン耐性に関する構造学的解析 (2015)
  • Author(s): 柳原格、名倉由起子
  • Organizer: 第３５回近畿腸管微生物研究会
  • Place of Presentation: 大阪
  • Year and Date: 2015-06-13
• [Presentation] TUBA1A mutation can cause hydrencephaly, the most severe form of lissencephaly. (2015)
  • Author(s): 4.Setsuri Yokoi, Naoko Ishihara, Jun Natsume, Hiroyuki Yamamoto, Makiko Tsutsumi, Itaru Yanaighara, Mtsuhiro Kato, Tatsuhiko Tsunoda, Kenjiro Kosaki, Yonehiro Kanemura, Fuyuki Miya, Shinji Saitoh, Hiroki Kurahashi.
  • Organizer: 第57回日本小児神経学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-05-28
• [Presentation] 腸炎ビブリオの産生する耐熱性溶血毒のＡｒｒｈｅｎｉｕｓ効果の謎を解く～ゆで卵が生卵になる！？～ (2015)
  • Author(s): 柳原格
  • Organizer: 第１回近畿大学高圧蛋白研セミナー
  • Place of Presentation: 大阪
  • Year and Date: 2015-05-28
  • Invited
• [Presentation] ヒトウレアプラズマ感染と早産 (2015)
  • Author(s): 柳原格
  • Organizer: 第42回日本マイコプラズマ学会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-22
  • Invited
• [Presentation] 水無脳症を呈したTUBA1A遺伝子異常の一例 (2014)
  • Author(s): 横井摂理、石原尚子、夏目淳、堤真紀子、大江瑞恵、加藤武馬、稲垣秀人、柳原格、斉藤伸治、倉橋浩樹
  • Organizer: 日本人類遺伝学会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-19 – 2014-11-22
• [Presentation] 気管チューブと羊水を材料としたウレアプラズマ（U）検出の疫学的検討 (2014)
  • Author(s): 江頭政和、岩出晃、川崎祥平、井上博晴、江頭智子、水上朋子、高柳俊光、柳原格
  • Organizer: 日本未熟児新生児学会
  • Place of Presentation: 愛媛
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] MALDIバイオタイパーによるウレアプラズマのますスペクトル取得の試み(第1報) (2014)
  • Author(s): 入村健児、清家奈保子、園田敏雅、柳原格
  • Organizer: 日臨技九州支部医学検査学会
  • Place of Presentation: 沖縄
  • Year and Date: 2014-11-01 – 2014-11-02
• [Presentation] Complete Genome Sequence of Ureaplasma parvum serovar 3 Strain SV3F4, Isolated in Japan (2014)
  • Author(s): Heng Ning Wu, Yukiko Nakura , Itaru Yanagihara
  • Organizer: Meeting of the Asian Organization for Mycoplasmology
  • Place of Presentation: Hunan, China
  • Year and Date: 2014-08-22 – 2014-08-25
• [Presentation] Detection of in vivo G-quadruplex structure of the ANXA5 promoter that contributes to the recurrent pregnancy loss (2014)
  • Author(s): Hidehito Inagaki, Sayuri Ota, Hironori Miyamura, Makiko Tsutsumi, Takema Kato, Haruki Nishizawa, Itaru Yanagihara, Hiroki Kurahashi
  • Organizer: The AMERICAN SOCIETY of HUMAN GENETICS
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2014-08-18 – 2014-08-22
• [Presentation] プロゲステロン、フラーレンによるTLR2依存的炎症反応への抑制効果 (2014)
  • Author(s): 脇本哲、内田薫、味村和哉、金川武司、青島央江、小久保研 、木村正、柳原格
  • Organizer: 日本プロテアーゼ学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-08-08 – 2014-08-09
• [Presentation] 流早産起因微生物ウレアプラズマの薬剤耐性遺伝子解析 (2014)
  • Author(s): 名倉由起子、脇本哲、野見山亮、徳田諭道、高柳俊光、白石淳、北島博之、中山雅弘、光田信明、竹内真、柳原格
  • Organizer: 日本周産期・新生児医学会
  • Place of Presentation: 千葉
  • Year and Date: 2014-07-13 – 2014-07-15
• [Presentation] 早産関連菌ウレアプラズマの炎症反応誘導機構 (2014)
  • Author(s): 柳原格、名倉由起子
  • Organizer: 近畿腸管微生物研究会
  • Place of Presentation: 大阪
  • Year and Date: 2014-06-14
  • Invited
• [Presentation] Progesterone, FullereneのTLR2依存性炎症反応に対する影響の検討 (2014)
  • Author(s): 脇本哲、味村和哉、金川武司、林周作、石井桂介、光田信明 柳原格、木村正
  • Organizer: 日本産婦人科感染症研究会
  • Place of Presentation: 神戸
  • Year and Date: 2014-06-07 – 2014-06-08
  • Invited
• [Presentation] 日本で単離されたウレアプラズマ臨床分離株の全ゲノム配列 (2014)
  • Author(s): 呉恒寧、名倉由起子、柳原格
  • Organizer: 日本マイコプラズマ学会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-22 – 2014-05-23
• [Presentation] Ureaplasma parvum の細胞内動態解析 (2014)
  • Author(s): 西海史子、柳原格
  • Organizer: 日本マイコプラズマ学会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-22 – 2014-05-23
• [Book] 最新マイコプラズマ学 周産期におけるマイコプラズマ感染症 (2016)
  • Author(s): 柳原格
  • Total Pages: 3
  • Publisher: 近代出版
• [Book] 最新マイコプラズマ学 (2016)
  • Author(s): 神谷茂編 柳原格他
  • Total Pages: 259
  • Publisher: 近大出版
• [Remarks] 大阪母子医療センター研究所免疫部門
  • URL: https://www.mch.pref.osaka.jp/research/developmental/index.html
• [Remarks] 大阪府立母子保健総合医療センター研究所免疫部門
  • URL: http://www.mch.pref.osaka.jp/research/developmental/index.html
• [Patent(Industrial Property Rights)] 新規ｃＤＮＡ合成法 (2015)
  • Inventor(s): 柳原格 他
  • Industrial Property Rights Holder: 柳原格 他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-11-27